Protein Overview: SHIP1_RAT

General Information:
Name(s) found:	SHIP1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9506813\|ref\|NP_062184.1\| inositol polyphosphate-5-phosphatase D [Rattus norvegicus] [NCBI NR] gi\|81861707\|sp\|P97573.1\|SHIP1_RAT RecName: Full=Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; AltName: Full=SH2 domain-containing inositol-5'-phosphatase 1; AltName: Full=SH2 domain-containing inositol phosphatase 1; Short=SHIP-1 [NCBI NR] gi\|1777942\|gb\|AAB40610.1\| inositol polyphosphate 5' phosphatase Ship [NCBI NR] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Rattus norvegicus GN=Inpp5d PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):9-95373859 Inositol polyphosphate 5' phosphatase Ship [hmr_yeast5_DM3-1_pombe.fasta] inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase; Inositol polyphosphate-5-phosphatase, 145 kDa; Inositol polyphosphate-5-phosphatase 145 kDa [HMR_022704-rand.fasta] inositol polyphosphate-5-phosphatase D [Rattus norvegicus]gi\|1777942\|gb\|AAB40610.1\| inositol polyphosphate 5' phosphatase Ship [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Inositol polyphosphate 5' phosphatase Ship [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_019311) Inositol polyphosphate-5-phosphatase, 145 kDa; Inositol polyphosphate-5-phosphatase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (SH2 domain-containing inositol-5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] inositol polyphosphate-5-phosphatase D [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] inositol polyphosphate 5' phosphatase Ship [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 INOSITOL POLYPHOSPHATE 5' PHOSPHATASE SHIP [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Inpp5d Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [rat-ipi-250309-contam.fasta] Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 OS=Rattus norvegicus GN=Inpp5d [011711_HMR.fasta] Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 OS=Rattus norvegicus GN=Inpp5d PE=1 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	1190 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [IDA] cytoplasm [IEA] cytosol [UNKNOWN] plasma membrane [IDA]
Biological Process:	negative regulation of interleukin-6 biosynthetic process [UNKNOWN][IEA] biological_process [ND] negative regulation of cell proliferation [UNKNOWN][IEA] determination of adult lifespan [UNKNOWN][IEA] positive regulation of lymphocyte differentiation [UNKNOWN] negative regulation of bone resorption [UNKNOWN][IEA] positive regulation of erythrocyte differentiation [UNKNOWN][IEA] negative regulation of neutrophil differentiation [UNKNOWN][IEA] positive regulation of B cell differentiation [UNKNOWN][IEA] negative regulation of monocyte differentiation [UNKNOWN][IEA] negative regulation of signal transduction [UNKNOWN][IEA] intracellular signaling pathway [UNKNOWN][IEA] negative regulation of B cell proliferation [UNKNOWN][IEA] immunoglobulin mediated immune response [UNKNOWN][IEA] positive regulation of apoptosis [UNKNOWN][IEA] negative regulation of osteoclast differentiation [UNKNOWN][IEA] negative regulation of B cell activation [UNKNOWN] negative regulation of immune response [UNKNOWN][IEA] negative regulation of granulocyte differentiation [UNKNOWN]
Molecular Function:	inositol or phosphatidylinositol phosphatase activity [IEA] protein binding [UNKNOWN][IDA][IEA] phosphatidylinositol trisphosphate phosphatase activity [UNKNOWN][IEA] SH3 domain binding [UNKNOWN][IEA] inositol-4,5-bisphosphate 5-phosphatase activity [IDA] inositol-polyphosphate 5-phosphatase activity [UNKNOWN][IEA] hydrolase activity [IEA] PTB domain binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR NCVYTYRILP  60
   61 NEDDKFTVQA SEGVPMRFFT KLDQLIEFYK KENMGLVTHL QFPVPLEEED AIDEPEEDTE 120
  121 SVMSPPELPP RNIPVSGGPC EAKDLPLPTE NPRAPEVTRL SLSETLFQRL QSMDTSGLPE 180
  181 EHLKAIQDYL STQLMLDSDF LKTGSSNLPH LKKLTSLLCK ELHGEVIRTL PSLESLQRLF 240
  241 DQQLSPGLRP RPQVPGEANP ITMVAKLSQL TSLLSSIEDK VKALLHEGSE STNRRSLIPP 300
  301 VTFEVKSESL GIPQKMHLKV DVESGKLIIK KSRDGSEDKF YSHKKILQLI KSQKFLNKLV 360
  361 ILVETEKEKI LRKEYVFSDS KKREGFCQLL QQMKNKHSEQ SEPDMITIFI GTWNMGNAPP 420
  421 PKKITSWFLS KGQGKTRDDS ADYIPHDIYV IGTQEDPLGE KEWLEILRHS LQEVTSMTFK 480
  481 TVAIHTLWNI RIVVLAKPEH ENRISHICTD NVKTGIANTL GNKGAVGVSF MFNGTSLGFV 540
  541 NSHLTSGSEK KLRRNQNYMN ILRFLALGDK KLSPFNITHR FTHLFWLGDL NYRVELPTWE 600
  601 AEAIIQKIKQ QQYSDLLAHD QLLLERKEQE VFLHFEEEEI TFAPTYRFER LTRDKYAYTK 660
  661 QKATGMKYNL PSWCDRVLWK SYPLVHVVCQ SYGSTSDIMT SDHSPVFATF EAGVTSQFVS 720
  721 KNGPGAVDSQ GQIEFLACYA TLKTKSQTKF YLELHSSCLE SFVKSQEGEN EEGDEGELVV 780
  781 RFGETLPKLK PIISDPEYLL DQHILISIKS SDSDESYGEG CIALRLETTE SQLPIYTPLT 840
  841 HHGEMTGHFR GEIKLQTSEG KMREKLYDFV KTERDESSGM KCLKNLTSHD PMRQWEPAGR 900
  901 VPACGISSLN EIINPNYIGM GPFGQPLHGK STLSPDQQLT AWSYDQLPKD SSLGPGRGEG 960
  961 PPTPPSQPPL SPKKFSSSTA NRGSCPRVQE TRPGDLGKVE ALPQEDLPLT KPEMFENPLY1020
 1021 GSVSPFPKLV PRKEQESPKM MRKEPPPCPD PGVSSPSIML PKAQEVENVK GTSKQAPVPV1080
 1081 FGPTPRIRSF TCSSSAEGRM PSGDKSQGKP KAPASSQAPV PVKRPVKPSR SEMSQQTTPI1140
 1141 PAPRPPLPVK SPAVLQLQHS KGRDYRDNTE LPHHGKHRQE ESLLGRTAMQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: SHIP1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: