Protein Overview: INSI2_RAT

General Information:
Name(s) found:	INSI2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|81873105\|sp\|Q80UA9.1\|INSI2_RAT RecName: Full=Insulin-induced gene 2 protein; Short=INSIG-2 [NCBI NR] gi\|55250700\|gb\|AAH85682.1\| Insulin induced gene 2 [Rattus norvegicus] [NCBI NR] gi\|30017409\|ref\|NP_835192.1\| insulin induced gene 2 [Rattus norvegicus] [NCBI NR] gi\|28901613\|gb\|AAN78347.1\| INSIG2 membrane protein [Rattus norvegicus] [NCBI NR] Insulin-induced gene 2 protein OS=Rattus norvegicus GN=Insig2 PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):13-27043598 INSIG2 membrane protein [hmr_yeast5_DM3-1_pombe.fasta] insulin induced gene 2 [HMR_022704-rand.fasta] Insulin induced gene 2 [Rattus norvegicus]gi\|30017409\|ref\|NP_835192.1\| insulin induced gene 2 [Rattus norvegicus]gi\|28901613\|gb\|AAN78347.1\| INSIG2 membrane protein [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 INSIG2 membrane protein [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Insulin-induced gene 2 protein (INSIG-2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] insulin induced gene 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Insulin induced gene 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] INSIG2 membrane protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 INSIG2 MEMBRANE PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Insig2 Insulin-induced gene 2 protein [rat-ipi-250309-contam.fasta] Insulin-induced gene 2 protein OS=Rattus norvegicus GN=Insig2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	225 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [IEA] SREBP-SCAP-Insig complex [UNKNOWN] membrane [IEA] integral to membrane [IEA] endoplasmic reticulum [IDA]
Biological Process:	negative regulation of fatty acid biosynthetic process [UNKNOWN][IEA] cranial suture morphogenesis [UNKNOWN][IEA] palate development [UNKNOWN][IEA] cholesterol biosynthetic process [UNKNOWN][IEA] cholesterol metabolic process [UNKNOWN] triglyceride metabolic process [UNKNOWN][IEA] steroid metabolic process [IEA] middle ear morphogenesis [UNKNOWN][IEA] response to sterol depletion [UNKNOWN][IEA] ER-nuclear sterol response pathway [UNKNOWN] response to insulin stimulus [IEP] inner ear morphogenesis [UNKNOWN][IEA] response to lipid [IEP] response to fatty acid [IEP] sterol biosynthetic process [UNKNOWN] negative regulation of steroid biosynthetic process [UNKNOWN][IEA]
Molecular Function:	protein binding [UNKNOWN] transcription factor binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEGETESPR PKKRGPYISS VTSQSVNVVI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP  60
   61 DVITSIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH 120
  121 ASAKVDFDNN FQFSLTLAAL SVGLWWTFDR SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY 180
  181 TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHQE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: INSI2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: