Protein Overview: PDE5A_RAT

General Information:
Name(s) found:	PDE5A_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|5921804\|sp\|O54735.1\|PDE5A_RAT RecName: Full=cGMP-specific 3',5'-cyclic phosphodiesterase; AltName: Full=cGMP-binding cGMP-specific phosphodiesterase; Short=CGB-PDE [NCBI NR] gi\|2662379\|dbj\|BAA23672.1\| cGMP-binding cGMP-specific phosphodiesterase [Rattus norvegicus] [NCBI NR] gi\|19424280\|ref\|NP_598268.1\| phosphodiesterase 5A [Rattus norvegicus] [NCBI NR] cGMP-specific 3',5'-cyclic phosphodiesterase OS=Rattus norvegicus GN=Pde5a PE=2 SV=1 [Swiss-Prot] (O54735) cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase) [Swiss-Prot] Ensembl_locations(Chr-bp):2-213455110 phosphodiesterase 5A, cGMP-specific [hmr_yeast5_DM3-1_pombe.fasta] phosphodiesterase 5A, cGMP-specific [HMR_022704-rand.fasta] phosphodiesterase 5A, cGMP-specific [Rattus norvegicus]gi\|5921804\|sp\|O54735\|CN5A_RAT cGMP-specific 3',5'-cyclic phosphodiesterase (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase)gi\|2662379\|dbj\|BAA23672.1\| cGMP-binding cGMP-specific phosphodieste [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform PDE5A2 of cGMP-specific 3',5'-cyclic phosphodiesterase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_133584) phosphodiesterase 5A, cGMP-specific [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] cGMP-specific 3',5'-cyclic phosphodiesterase (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] phosphodiesterase 5A, cGMP-specific [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cGMP-binding cGMP-specific phosphodiesterase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cGMP-specific 3',5'-cyclic phosphodiesterase (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase) [nr-271106-contam.fasta] Isoform PDE5A2 of cGMP-specific 3',5'-cyclic phosphodiesterase OS=Rattus norvegicus GN=Pde5a [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	833 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA]
Biological Process:	regulation of the force of heart contraction [IMP] short-term memory [IMP] response to hypoxia [IEP] positive regulation of chronic inflammatory response [IMP] signal transduction [IEA] cGMP catabolic process [UNKNOWN][IEA] positive regulation of apoptosis [IMP] positive regulation of vasoconstriction [IMP] nervous system development [IEP] response to lipopolysaccharide [IEP] response to testosterone stimulus [IEP] vasodilation [IEP]
Molecular Function:	nucleotide binding [IEA] metal ion binding [IEA] 3',5'-cyclic-GMP phosphodiesterase activity [IDA][TAS] cyclic-nucleotide phosphodiesterase activity [UNKNOWN] cGMP binding [UNKNOWN][IEA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPFGDKTRD MVNAWFSERV HNIPVCKEGI RAHTESCSCS LPQSPHADNT TPGAPARKIS  60
   61 ASEFDRPLRP IVVKDSEGTV SFLSDSGKKE QMPLTSPRFD SDEGDQCSRL LELVKDISSH 120
  121 LDVTALCHKI FLHIHGLISA DRYSLFLVCE DSSKDKFLVS RLFDVAEGST LEEASNNCIR 180
  181 LEWNKGIVGH VAAFGEPLNI KDAYEDPRFN AEVDQITGYK TQSILCMPIK NHREEVVGVA 240
  241 QAINKKSGNG GTFTEKDEKD FAAYLAFCGI VLHNAQLYET SLLENKRNQV LLDLASLIFE 300
  301 EQQSLEVILK KIAATIISFM QVQKCTIFIV DEDCPDSFSR VFQMEWEEVG KSSEPLTREH 360
  361 DANKINYMYA QYVKNTMEPL NIPDVTKDNR FPWTNENMGH INTHCIRSLL CTPIKNGKKN 420
  421 KVIGVCQLVN KMEEKTGKIK AFNQNDEQFL EAFVIFCGLG IQNTQMYEAV ERAMAKQMVT 480
  481 LEVLSYHASA AEEETRELQA LAAAVVPSAQ TLKITDFSFS DFELSDLETA LCTIRMFTDL 540
  541 NLVQNFQMKH EVLCRWILSV KKNYRKNVAY HNWRHAFNTA QCMFAALKAG KIQNKLTDLE 600
  601 TLALLIAALS HDLDHRGVNN SYIQRSEHPL AQLYCHSTME HHHFDQCLMV LNSPGNQILS 660
  661 GLSIEEYKTT LKIIKQAILA TDLALYIKRR GEFFELIRKN EFSFEDPLQK ELFLAMLMTA 720
  721 CDLSAITKPW PIQQRIAELV AAEFFDQGDR ERKELNMEPA DLMNREKKNK IPSMQVGFID 780
  781 AICLQLYEAL THVSEDCLPL LDGCRKNRQK WQALADQQEK TLLNGESGQA KRD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Protein Overview: PDE5A_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: