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Protein Overview: IL1A_RAT

General Information:
Name(s) found: IL1A_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Interleukin-1 alpha OS=Rattus norvegicus GN=Il1a PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 270 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][ISS]
    cytosol [UNKNOWN][ISS]
    extracellular region [IDA]
    cell surface [IDA]
    Biological Process: negative regulation of cell proliferation [UNKNOWN][IEA]
    positive regulation of I-kappaB kinase/NF-kappaB cascade [IDA]
    positive regulation of mitosis [UNKNOWN][IEA]
    positive regulation of angiogenesis [IEA]
    inflammatory response [NAS]
    wound healing [IEP]
    immune response [IEA]
    cellular response to heat [UNKNOWN][ISS]
    positive regulation of cell division [IEA]
    cytokine-mediated signaling pathway [UNKNOWN][IEA]
    positive regulation of cytokine secretion [UNKNOWN][IEA]
    response to gamma radiation [IEP]
    positive regulation of steroid biosynthetic process [IDA]
    positive regulation vascular endothelial growth factor production [IEA]
    response to L-ascorbic acid [IEP]
    response to organic substance [IEP]
    response to ozone [IEP]
    response to copper ion [UNKNOWN][ISS]
    response to organic cyclic substance [IEP]
    fever [IEA]
    positive regulation of interleukin-2 biosynthetic process [UNKNOWN][IEA]
    positive regulation of JNK cascade [IDA]
    positive regulation of ERK1 and ERK2 cascade [IDA]
    response to lipopolysaccharide [IEP]
    positive regulation of interleukin-6 production [IMP]
    response to organic nitrogen [IEP]
    positive regulation of stress-activated MAPK cascade [IDA]
    regulation of sensory perception of pain [IDA]
    Molecular Function: protein binding [UNKNOWN][IEA]
    interleukin-1, Type I receptor binding [NAS]
    copper ion binding [UNKNOWN][ISS]
    cytokine activity [UNKNOWN][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKVPDLFED LKNCYSENEE YSSAIDHLSL NQKSFYDASY GSLHENCTDK FVSLRTSETS  60
   61 KMSTFTFKES RVVVSATSNK GKILKKRRLS FNQPFTEDDL EAIAHDLEET IQPRSAPHSF 120
  121 QNNLRYKLIR IVKQEFIMND SLNQNIYVDM DRIHLKAASL NDLQLEVKFD MYAYSSGGDD 180
  181 SKYPVTLKVS NTQLFVSAQG EDKPVLLKEI PETPKLITGS ETDLIFFWEK INSKNYFTSA 240
  241 AFPELLIATK EQSQVHLARG LPSMIDFQIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle