Protein Overview: AT2A1_RAT

General Information:
Name(s) found:	AT2A1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9789714\|sp\|Q64578.1\|AT2A1_RAT RecName: Full=Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Short=SERCA1; AltName: Full=Calcium pump 1; AltName: Full=Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Alt [NCBI NR] pir\|\|A48849 Ca2+-transporting ATPase (EC 3.6.3.8) SERCA1a, sarcoplasmic reticulum - rat [NCBI NR] gi\|445664\|prf\|\|1910193A sarcoplasmic reticulum Ca ATPase [NCBI NR] gi\|203645\|gb\|AAA40991.1\| calcium transporting ATPase [NCBI NR] gi\|195540259\|gb\|AAI68245.1\| ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Rattus norvegicus] [NCBI NR] gi\|17157987\|ref\|NP_478120.1\| ATPase, Ca++ transporting, fast twitch 1 [Rattus norvegicus] [NCBI NR] gi\|149067919\|gb\|EDM17471.1\| ATPase, Ca++ transporting, cardiac muscle, fast twitch 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] (Q64578) Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (EC 3.6.3.8) (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class [Swiss-Prot] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Rattus norvegicus GN=Atp2a1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):1-179316580 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [hmr_yeast5_DM3-1_pombe.fasta] ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [HMR_022704-rand.fasta] ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Rattus norvegicus]gi\|9789714\|sp\|Q64578\|ATA1_RAT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticul [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_058213) ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (SR Ca(2+)-ATPase 1) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ATPase, Ca++ transporting, cardiac muscle, fast twitch 1, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] calcium transporting ATPase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] sarcoplasmic reticulum Ca ATPase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] ATPase, Ca++ transporting, fast twitch 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Atp2a1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [rat-ipi-250309-contam.fasta] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Rattus norvegicus GN=Atp2a1 [011711_HMR.fasta] ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 OS=Rattus norvegicus GN=Atp2a1 [011711_HMR.fasta] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Rattus norvegicus GN=Atp2a1 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	994 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [UNKNOWN][ISS] perinuclear region of cytoplasm [ISS] sarcoplasmic reticulum [UNKNOWN][IDA][ISS][TAS] membrane [ISS] microsome [UNKNOWN][IDA] integral to membrane [IEA] H zone [UNKNOWN][ISS] I band [UNKNOWN][ISS] endoplasmic reticulum [ISS] ER-Golgi intermediate compartment [ISS] sarcoplasmic reticulum membrane [IEA]
Biological Process:	calcium ion import [UNKNOWN] elevation of endoplasmic reticulum calcium ion concentration [UNKNOWN] metabolic process [IEA] reduction of endoplasmic reticulum calcium ion concentration [UNKNOWN] ATP catabolic process [ISS] ATP biosynthetic process [IEA] negative regulation of striated muscle contraction [UNKNOWN][ISS] regulation of striated muscle contraction [UNKNOWN][ISS] response to peptide hormone stimulus [IDA] positive regulation of fast-twitch skeletal muscle fiber contraction [UNKNOWN][ISS] cation transport [IEA] apoptotic mitochondrial changes [UNKNOWN] elevation of mitochondrial calcium ion concentration [UNKNOWN] calcium ion transport [UNKNOWN][IDA][ISS] regulation of muscle contraction [TAS] maintenance of mitochondrion location [UNKNOWN] apoptosis in response to endoplasmic reticulum stress [UNKNOWN] response to endoplasmic reticulum stress [UNKNOWN]
Molecular Function:	nucleotide binding [IEA] nucleotide-sugar transmembrane transporter activity [IDA] ATP binding [IDA][ISS] protein binding [UNKNOWN][IPI] protein homodimerization activity [UNKNOWN] calcium ion binding [UNKNOWN][IDA][ISS] calcium-transporting ATPase activity [UNKNOWN][IDA][IMP][ISS] hydrolase activity [IEA] hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAAHSKSTE ECLSYFGVSE TTGLTPDQVK RHLEKYGPNE LPAEEGKSLW ELVVEQFEDL  60
   61 LVRILLLAAC ISFVLAWFEE GEETVTAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 120
  121 EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILSIKS TTLRVDQSIL 180
  181 TGESVSVIKH TDPVPDPRAV NQDKKNMLFS GTNIAAGKAV GIVATTGVST EIGKIRDQMA 240
  241 ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 300
  301 ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 360
  361 MSVCKMFIID KVDGDICSLN EFSITGSTYA PEGEVLKNDK PVRAGQYDGL VELATICALC 420
  421 NDSSLDFNET KGVYEKVGEA TETALTTLVE KMNVFNTEVR SLSKVERANA CNSVIRQLMK 480
  481 KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 540
  541 VKEKIMSVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SAKFMEYEMD LTFVGVVGML 600
  601 DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFSENEEVAD RAYTGREFDD 660
  661 LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 720
  721 GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 780
  781 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 840
  841 GGYVGAATVG AAAWWFLYAE DGPHVSYHQL THFMQCTEHN PEFDGLDCEV FEAPEPMTMA 900
  901 LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 960
  961 ALDFTQWLMV LKISLPVIGL DELLKFIARN YLEG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: AT2A1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: