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Protein Overview: LIPS_RAT

General Information:
Name(s) found: LIPS_RAT [Swiss-Prot]
Description(s) found:
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  • gi|85690847|sp|P15304.3|LIPS_RAT RecName: Full=Hormone-sensitive lipase; Short=HSL [NCBI NR]
  • gi|6981164|ref|NP_036991.1| hormone-sensitive lipase [Rattus norvegicus] [NCBI NR]
  • gi|1488679|gb|AAC52771.1| hormone-sensitive lipase testicular isoform [NCBI NR]
  • Hormone-sensitive lipase OS=Rattus norvegicus GN=Lipe PE=1 SV=3 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-77794562 lipase, hormone sensitive [hmr_yeast5_DM3-1_pombe.fasta]
  • lipase, hormone sensitive; Hormone - sensitive lipase, testicular isoform; lipase, hormone sensitive; Hormone - sensitive lipase testicular isoform; lipase hormone sensitive [HMR_022704-rand.fasta]
  • lipase, hormone sensitive [Rattus norvegicus]gi|1488679|gb|AAC52771.1| hormone-sensitive lipase testicular isoform [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform 1 of Hormone-sensitive lipase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Hormone-sensitive lipase testicular isoform [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • (NM_012859) lipase, hormone sensitive; Hormone - sensitive lipase, testicular isoform [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Hormone-sensitive lipase (HSL) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • lipase, hormone sensitive [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • hormone-sensitive lipase testicular isoform [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 HORMONE-SENSITIVE LIPASE TESTICULAR ISOFORM [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Lipe Isoform 1 of Hormone-sensitive lipase [rat-ipi-250309-contam.fasta]
  • Isoform 1 of Hormone-sensitive lipase OS=Rattus norvegicus GN=Lipe [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 1068 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [UNKNOWN]
    nucleus [ISS]
    extracellular space [IDA]
    caveola [ISS]
    cytoplasm [IDA][ISS]
    mitochondrion [ISS]
    cytosol [UNKNOWN]
    plasma membrane [IEA]
    Biological Process: diacylglycerol catabolic process [UNKNOWN][IEA]
    transcription initiation from RNA polymerase I promoter [ISS]
    response to drug [IEP]
    metabolic process [IEA]
    lipid catabolic process [TAS]
    cholesterol metabolic process [IEA]
    female pregnancy [IEP]
    steroid metabolic process [IEA]
    triglyceride catabolic process [UNKNOWN][IDA]
    Molecular Function: hydrolase activity, acting on ester bonds [IDA]
    acylglycerol lipase activity [IDA]
    protein binding [UNKNOWN][IPI]
    RNA polymerase I transcription termination factor activity [ISS]
    triglyceride lipase activity [UNKNOWN][IEA]
    rRNA primary transcript binding [ISS]
    hormone-sensitive lipase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPRRPISFT REITAMEPSS TSVSRPEWRP EAQQTLTDYP GSRELQEFGI PQKQSLPNEA  60
   61 TAQQGAEFQQ EQGVQQSTLL QKLLTPLAFP VPQQSFPSHK VHSDQQEATS QNGPGAGKVH 120
  121 TTQKELEHRD EHVGTAESGP AEPPPATEVE ATSIAQAVSG PDKKLPTQTD LVSQERAEQS 180
  181 DPTAQQTPLV QGVKSDQGSL IESGILARLQ KLAIQQPSQE WKTFLDCVTE SDMEKYLNSS 240
  241 SKSNPPEPSG GTVIPGTLPS KQKPDCGKMS GYGGKLPHGK KGILQKHKHY WDTASAFSHS 300
  301 MDLRTMTQSL VALAEDNMAF FSSQGPGETA RRLSNVFAGV REQALGLEPT LGQLLGVAHH 360
  361 FDLDTETPAN GYRSLVHTAR CCLAHLLHKS RYVASNRRSI FFRASHNLAE LEAYLAALTQ 420
  421 LRALAYYAQR LLTINRPGVL FFEGDEGLSA DFLQDYVTLH KGCFYGRCLG FQFTPAIRPF 480
  481 LQTLSIGLVS FGEHYKRNET GLSVTASSLF TGGRFAIDPE LRGAEFERII QNLDVHFWKA 540
  541 FWNITEIEVL SSLANMASTT VRVSRLLSLP PEAFEMPLTS DPKLTVTISP PLAHTGPGPV 600
  601 LARLISYDLR EGQDSKMLNS LAKSEGPRLE LRPRPQQAPR SRALVVHIHG GGFVAQTSKS 660
  661 HEPYLKNWAQ ELGVPIISID YSLAPEAPFP RALEECFFAY CWAVKHCELL GSTGERICLA 720
  721 GDSAGGNLCI TVSLRAAAYG VRVPDGIMAA YPVTTLQSSA SPSRLLSLMD PLLPLSVLSK 780
  781 CVSAYSGTET EDHFDSDQKA LGVMGLVQRD TSLFLRDLRL GASSWLNSFL ELSGRKPHKT 840
  841 PLPATETLRP TDSGRLTESM RRSVSEAALA QPEGLLGTDS LKKLTIKDLS FKGNSEPSDS 900
  901 PEMSQSMETL GPSTPSDVNF FLRSGNSQEE AETRDDISPM DGIPRVRAAF PDGFHPRRSS 960
  961 QGVLHMPLYS SPIVKNPFMS PLLAPDVMLK TLPPVHLVAC ALDPMLDDSV MFARRLKDLG1020
 1021 QPVTLKVVED LPHGFLSLAA LCRETRQAAE LCVQRIRLIL TPPAAPLT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle