Protein Overview: GSH1_RAT

General Information:
Name(s) found:	GSH1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|51859416\|gb\|AAH81702.1\| Glutamate-cysteine ligase, catalytic subunit [Rattus norvegicus] [NCBI NR] gi\|25742748\|ref\|NP_036947.1\| glutamate-cysteine ligase, catalytic subunit [Rattus norvegicus] [NCBI NR] gi\|204282\|gb\|AAA41208.1\| gamma-glutamylcysteine synthetase [NCBI NR] gi\|149019120\|gb\|EDL77761.1\| glutamate-cysteine ligase, catalytic subunit, isoform CRA_c [Rattus norvegicus] [NCBI NR] gi\|121662\|sp\|P19468.2\|GSH1_RAT RecName: Full=Glutamate--cysteine ligase catalytic subunit; AltName: Full=Gamma-glutamylcysteine synthetase; AltName: Full=Gamma-ECS; AltName: Full=GCS heavy chain [NCBI NR] pir\|\|A35015 glutamate-cysteine ligase (EC 6.3.2.2) heavy chain - rat [NCBI NR] Glutamate--cysteine ligase catalytic subunit OS=Rattus norvegicus GN=Gclc PE=1 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):8-81038806 glutamate-cysteine ligase catalytic subunit [hmr_yeast5_DM3-1_pombe.fasta] glutamate-cysteine ligase catalytic subunit; Glutamylcysteine gamma synthetase light chain; glutamate-cysteine ligase, catalytic subunit [HMR_022704-rand.fasta] glutamate-cysteine ligase catalytic subunit [Rattus norvegicus]gi\|51859416\|gb\|AAH81702.1\| Glutamate-cysteine ligase catalytic subunit [Rattus norvegicus]gi\|121662\|sp\|P19468\|GSH1_RAT Glutamate--cysteine ligase catalytic subunit (Gamma-glutamylcysteine sy [nrdb_11152004_Chlamydomonas] Glutamate--cysteine ligase catalytic subunit (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS heavy chain) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] glutamate-cysteine ligase, catalytic subunit [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] glutamate-cysteine ligase, catalytic subunit, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Glutamate-cysteine ligase, catalytic subunit [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] gamma-glutamylcysteine synthetase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 GLUTAMATE-CYSTEINE LIGASE CATALYTIC SUBUNIT [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] glutamate-cysteine ligase catalytic subunit [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Gclc Glutamate--cysteine ligase catalytic subunit [rat-ipi-250309-contam.fasta] Glutamate--cysteine ligase catalytic subunit OS=Rattus norvegicus GN=Gclc [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	637 amino acids
Gene Ontology:
Cellular Component:	glutamate-cysteine ligase complex [UNKNOWN][IDA] cytosol [UNKNOWN][IEA]
Biological Process:	glutathione biosynthetic process [UNKNOWN][IMP][ISS] cell redox homeostasis [UNKNOWN][ISS] response to xenobiotic stimulus [UNKNOWN][IEA] cysteine metabolic process [UNKNOWN][ISS] response to hormone stimulus [UNKNOWN][ISS] negative regulation of neuron apoptosis [IMP] response to oxidative stress [UNKNOWN][IMP][ISS] glutamate metabolic process [UNKNOWN][ISS] response to heat [UNKNOWN][ISS] anti-apoptosis [UNKNOWN][ISS] response to arsenic [UNKNOWN][IEA] regulation of blood vessel size [UNKNOWN][ISS] glutathione metabolic process [UNKNOWN] negative regulation of transcription [UNKNOWN][ISS] negative regulation of apoptosis [UNKNOWN] response to nitrosative stress [IMP] L-ascorbic acid metabolic process [UNKNOWN][IEA] negative regulation of protein ubiquitination [UNKNOWN][IEA] positive regulation of proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN][IEA] regulation of mitochondrial depolarization [UNKNOWN][IEA]
Molecular Function:	nucleotide binding [IEA] magnesium ion binding [UNKNOWN][ISS] ATP binding [IEA] coenzyme binding [UNKNOWN][ISS] protein heterodimerization activity [UNKNOWN][IDA] glutamate binding [UNKNOWN][ISS] ADP binding [UNKNOWN][ISS] glutamate-cysteine ligase activity [UNKNOWN][IMP][ISS] ligase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLSQGSPL SWEETQRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH  60
   61 ENRKVQLLLN GGDVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 120
  121 EDNMRKRRKE ATSVLGEHQA LCTITSFPRL GCPGFTLPEH RPNPEEGGAS KSLFFPDEAI 180
  181 NKHPRFGTLT RNIRHRRGEK VVINVPIFKD KNTPSPFVET FPEDEEASKA SKPDHIYMDA 240
  241 MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 300
  301 SASVDDRTRE ERGLEPLKNN RFKISKSRYD SIDSYLSKCG EKYNDIDLTI DTEIYEQLLE 360
  361 EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 420
  421 GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQERDAVL 480
  481 QGMFYFRKDI CKGGNAVVDG CSKAQTSSEP SAEEYTLMSI DTIINGKEGV FPGLIPILNS 540
  541 YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEINYS 600
  601 LILKCNQIAN ELCECPELLG SGFRKAKYSG GKSDPSD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: GSH1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: