Protein Overview: BIG2_RAT

General Information:
Name(s) found:	BIG2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|31342051\|ref\|NP_851597.2\| ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [Rattus norvegicus] [NCBI NR] gi\|31126988\|gb\|AAP04588.2\| Brefeldin A-inhibited guanine nucleotide-exchange factor 2 [Rattus norvegicus] [NCBI NR] Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Rattus norvegicus GN=Arfgef2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):3-151159438 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [hmr_yeast5_DM3-1_pombe.fasta] ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [HMR_022704-rand.fasta] ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [Rattus norvegicus]gi\|31126988\|gb\|AAP04588.2\| Brefeldin A-inhibited guanine nucleotide-exchange factor 2 [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Brefeldin A-inhibited guanine nucleotide-exchange factor 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Brefeldin A-inhibited guanine nucleotide-exchange factor 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE FACTOR 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Arfgef2 Brefeldin A-inhibited guanine nucleotide-exchange factor 2 [rat-ipi-250309-contam.fasta] Brefeldin A-inhibited guanine nucleotide-exchange factor 2 OS=Rattus norvegicus GN=Arfgef2 [011711_HMR.fasta] Brefeldin A-inhibited guanine nucleotide-exchange factor 2 OS=Rattus norvegicus GN=Arfgef2 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	1791 amino acids
Gene Ontology:
Cellular Component:	trans-Golgi network [IMP] cytoplasm [IDA] membrane [UNKNOWN][IEA] cytosol [UNKNOWN][IEA] Golgi membrane [UNKNOWN][IEA] intracellular [IEA]
Biological Process:	intracellular signaling pathway [UNKNOWN][IEA] regulation of ARF protein signal transduction [IEA] exocytosis [IMP]
Molecular Function:	ARF guanyl-nucleotide exchange factor activity [IEA] guanyl-nucleotide exchange factor activity [UNKNOWN][TAS] myosin binding [IPI] binding [IEA] GABA receptor binding [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQESQTKSMF VSRALEKILA DKEVKRPQHS QLRRACQVAL DEIKAELEKQ RLGAAAPPKA  60
   61 NFIEADKYFL PFELACQSKS PRVVSTSLDC LQKLIAYGHI TGNAPDSGAP GKRLIDRIVE 120
  121 TVCNCFQGPQ TDEGVQLQII KALLTAVTSP HIEIHEGTIL QTVRTCYNIY LASKNLINQT 180
  181 TAKATLTQML NVIFTRMENQ VLQEARELEK PIQSKPQSPV IQATAGSPKF SRLKQSQAQS 240
  241 KPTTPEKTEL PNGDHARSSL GKVNSENGEA HRERGSSISG RAEPSGGSDN GAQEVVKDIL 300
  301 EDVVTSAVKE AAEKQGLPEP DQAPGVPECQ ECTVPPAVDE NSQTNGIADD RQSLSSADNL 360
  361 EPDAQGHPVA ARFSHILQKD AFLVFRSLCK LSMKPLGEGP PDPKSHELRS KVVSLQLLLS 420
  421 VLQNAGPVFR SHEMFVTAIK QYLCVALSKN GVSSVPDVFE LSLAIFLTLL SNFKMHLKMQ 480
  481 IEVFFKEIFL NILETSTSSF EHRWMVIQTL TRICADAQCV VDIYVNYDCD LNAANIFERL 540
  541 VNDLSKIAQG RSGHELGMTP LQELSLRKKG LECLVSILKC MVEWSKDLYV NPNHQATLGQ 600
  601 ERLPDQEMGD GKGLDMARRC SVTSVESTVS SGTQTAIPDD PEQFEVIKQQ KEIIEHGIEL 660
  661 FNKKPKRGIQ FLQEQGMLGA AVEDIAQFLH QEERLDSTQV GEFLGDSTRF NKEVMYAYVD 720
  721 QLDFCEKEFV SALRTFLEGF RLPGEAQKID RLMEKFAARY IECNQGQTLF ASADTAYVLA 780
  781 YSIIMLTTDL HSPQVKNKMT KEQYIKMNRG INDSKDLPEE YLSSIYEEIE GKKIAMKETK 840
  841 EHTMATKSTK QNVASEKQRR LLYNVEMEQM AKTAKALMEA VSHAKAPFTS ATHLDHVRPM 900
  901 FKLVWTPLLA AYSIGLQNCD DTEVASLCLE GIRCAVRIAC IFGMQLERDA YVQALARFSL 960
  961 LTASSSITEM KQKNIDTIKT LITVAHTDGN YLGNSWHEIL KCISQLELAQ LIGTGVKTRY1020
 1021 LSGSGREREG SLKGHSLAGE EFMGLGLGNL VSGGVDKRQM ASFQESVGET SSQSVVVAVD1080
 1081 RIFTGSTRLD GNAIVDFVRW LCAVSMDELA SPHHPRMFSL QKIVEISYYN MNRIRLQWSR1140
 1141 IWHVIGDHFN KVGCNPNEDV AIFAVDSLRQ LSMKFLEKGE LANFRFQKDF LRPFEHIMKK1200
 1201 NRSPTIRDMV IRCIAQMVSS QAANIRSGWK NIFAVFHQAA SDHDGNIVEL AFQTTGHIVS1260
 1261 TIFQHHFPAA IDSFQDAVKC LSEFACNAAF PDTSMEAIRL IRFCGKYVSE RPRVLQEYTS1320
 1321 DDMNVAPGDR VWVRGWFPIL FELSCIINRC KLDVRTRGLT VMFEIMKSYG HTFAKHWWQD1380
 1381 LFRIVFRIFD NMKLPEQQSE KSEWMTTTCN HALYAICDVF TQFYEALHEV LLSDVFAQLQ1440
 1441 WCVKQDNEQL ARSGTNCLEN LVISNGEKFS PAVWDETCNC MLDIFRTTIP HVLLTWRPAG1500
 1501 MEEEVSDRHL DVDLDRQSLS SIDRNASERG QSQLSNPTDD SWKGAPYANQ KLLASLLIKC1560
 1561 VVQLELIQTI DNIVFYPATS KKEDAEHMVA AQQDTLDADI HIETENQGMY KFMSSQHLFK1620
 1621 LLDCLQESHS FSKAFNSNYE QRTVLWRAGF KGKSKPNLLK QETSSLACCL RILFRMYVDE1680
 1681 NRRDSWGEIQ QRLLTVCSEA LAYFITVNSE SHREAWTSLL LLLLTKTLKI NDEKFKAHAS1740
 1741 VYYPYLCEMM QFDLIPELRA VLRKFFLRIG LVYKIWVPEE PSQVPAASTA W

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: BIG2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: