Protein Overview: NEDD4_RAT

General Information:
Name(s) found:	NEDD4_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|32469607\|sp\|Q62940.1\|NEDD4_RAT RecName: Full=E3 ubiquitin-protein ligase NEDD4 [NCBI NR] pir\|\|S70642 ubiquitin ligase Nedd4 - rat (fragment) [NCBI NR] gi\|1293647\|gb\|AAB48949.1\| Nedd4 [Rattus norvegicus] [NCBI NR] E3 ubiquitin-protein ligase NEDD4 OS=Rattus norvegicus GN=Nedd4 PE=1 SV=1 [Swiss-Prot] (Q62940) E3 ubiquitin-protein ligase Nedd-4 (EC 6.3.2.-) [Swiss-Prot] Ensembl_locations(Chr-bp):8-75657191 Nedd4 [hmr_yeast5_DM3-1_pombe.fasta] Nedd4 [Rattus norvegicus]gi\|2144012\|pir\|\|S70642 ubiquitin ligase Nedd4 - rat (fragment)gi\|32469607\|sp\|Q62940\|NED4_RAT E3 ubiquitin-protein ligase Nedd-4 [nrdb_11152004_Chlamydomonas] E3 ubiquitin-protein ligase NEDD4 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Nedd4 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] E3 ubiquitin-protein ligase NEDD4 OS=Rattus norvegicus GN=Nedd4 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	887 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [UNKNOWN] perinuclear region of cytoplasm [UNKNOWN] ubiquitin ligase complex [UNKNOWN] cytoplasm [UNKNOWN][IEA] microvillus [IDA] cell cortex [UNKNOWN] membrane raft [IDA] cytosol [UNKNOWN] chromatin [UNKNOWN] intracellular [IEA] plasma membrane [UNKNOWN]
Biological Process:	glucocorticoid receptor signaling pathway [UNKNOWN] positive regulation of phosphoinositide 3-kinase cascade [UNKNOWN] neuron projection development [UNKNOWN] lysosomal transport [UNKNOWN] protein modification process [IEA] positive regulation of protein catabolic process [UNKNOWN] protein targeting to lysosome [UNKNOWN] positive regulation of nucleocytoplasmic transport [UNKNOWN] protein ubiquitination during ubiquitin-dependent protein catabolic process [UNKNOWN] receptor catabolic process [UNKNOWN] immune response [IEP] negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [UNKNOWN] transmission of virus [UNKNOWN] development during symbiotic interaction [UNKNOWN] negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS] cellular response to UV [UNKNOWN] progesterone receptor signaling pathway [UNKNOWN] negative regulation of sodium ion transport [UNKNOWN] receptor internalization [UNKNOWN] protein ubiquitination [UNKNOWN]
Molecular Function:	sodium channel regulator activity [IPI] RNA polymerase binding [UNKNOWN] ubiquitin-protein ligase activity [UNKNOWN] proline-rich region binding [UNKNOWN] protein domain specific binding [UNKNOWN] protein binding [UNKNOWN][IDA][IEA] ubiquitin binding [UNKNOWN] protein C-terminus binding [IDA][IPI] sodium channel inhibitor activity [UNKNOWN] acid-amino acid ligase activity [IEA] ligase activity [IEA] beta-2 adrenergic receptor binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAADDTEAPV LSEDEVWEFC LDKNEEGGGS PGSDVTDTCE PPCGCWELNP SSLEEEHVLF  60
   61 TAESIISSFN NDDTRVVRVK VIAGIGLAKK DILGASDPYV RVTLYDPMSG VLTSVQTKTI 120
  121 KKSLNPKWNE EILFRVLPQQ HRILFEVFDE NRLTRDDFLG QVDVPLYPLP TENPRMERPY 180
  181 TFKDFVLHPR SHKSRVKGYL RLKMTYLPKN GSDDENADQA EELEPGWVVL DQPDAATHLQ 240
  241 HPPEPSPLPP GWEERQDVLG RTYYVNHESR TTQWKRPSPE DDLTDDENGD IQLQAHGAFT 300
  301 TRRQISEDVD GPDNHESPEN WEIVREDENT IYSGQAVQSP PSGHPDVQVR LAEELDTRLT 360
  361 MYGNPATSQP VTSSNHSSRG GSSQTCIFEE QPTLPVLLPT SSGLPPGWEE KQDDRGRSYY 420
  421 VDHNSKTTTW SKPTMQDDPR SKIPAHLRGK TPVDSNDLGP LPPGWEERTH TDGRVFFINH 480
  481 NIKKTQWEDP RMQNVAITGP AEPYSRDYKR KYEFFRRKLK KQTDIPNKFE MKLRRANILE 540
  541 DSYRRIMGVK RADFLKARLW IEFDGEKGLD YGGVAREWFF LISKEMFNPY YGLFEYSATE 600
  601 DNYTLQINPN SGLCNEDHLS YFKFIGRVAG MAVYHGKLLD GFFIRPFYKM MLQKLITLHD 660
  661 MESVDSEYYS SLRWILENDP TELDLRFIID EELFGQTHQH ELKTGGSEVV VTNKNKKEYI 720
  721 YLVIQWRFVN RIQKQMAAFK EGFFELIPQD LIKIFDENEL ELLMCGLGDV DVNDWREHTK 780
  781 YKNGYSLNHQ VIHWFWKAVL MMDSEKRIRL LQFVTGTSRV PMNGFAELYG SNGPQSFTVE 840
  841 QWGTPDKLPR AHTCFNRLDL PPYESFDELW DKLQMAIENT QGFDGVD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: NEDD4_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: