Protein Overview: NEP_RAT

General Information:
Name(s) found:	NEP_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981210\|ref\|NP_036740.1\| membrane metallo endopeptidase [Rattus norvegicus] [NCBI NR] pir\|\|HYRTN neprilysin (EC 3.4.24.11) - rat [NCBI NR] gi\|55250728\|gb\|AAH85753.1\| Membrane metallo endopeptidase [Rattus norvegicus] [NCBI NR] gi\|204032\|gb\|AAA41116.1\| enkephalinase precursor (EC 3.4.24.11) [NCBI NR] gi\|149064666\|gb\|EDM14817.1\| membrane metallo endopeptidase, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149064665\|gb\|EDM14816.1\| membrane metallo endopeptidase, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|128065\|sp\|P07861.2\|NEP_RAT RecName: Full=Neprilysin; AltName: Full=Neutral endopeptidase 24.11; Short=Neutral endopeptidase; Short=NEP; AltName: Full=Enkephalinase; AltName: Full=Atriopeptidase; AltName: CD_antigen=CD10 [NCBI NR] Neprilysin OS=Rattus norvegicus GN=Mme PE=1 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):2-145143169;2-145143169;2-145143169 membrane metallo endopeptidase [hmr_yeast5_DM3-1_pombe.fasta] membrane metallo endopeptidase; membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase) [HMR_022704-rand.fasta] Mme protein [Rattus norvegicus]gi\|6981210\|ref\|NP_036740.1\| membrane metallo endopeptidase [Rattus norvegicus]gi\|67700\|pir\|\|HYRTN neprilysin (EC 3.4.24.11) - ratgi\|128065\|sp\|P07861\|NEP_RAT Neprilysin (Neutral endopeptidase) (NEP) (Enkephalinase)gi\|2040 [nrdb_11152004_Chlamydomonas] (NM_012608) membrane metallo endopeptidase; Membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Neprilysin (Neutral endopeptidase 24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Atriopeptidase) (CD10 antigen) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] membrane metallo endopeptidase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] membrane metallo endopeptidase, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Membrane metallo endopeptidase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] enkephalinase precursor (EC 3.4.24.11) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 MEMBRANE METALLO ENDOPEPTIDASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Neprilysin (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Mme Neprilysin [rat-ipi-250309-contam.fasta] Neprilysin OS=Rattus norvegicus GN=Mme [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	750 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] membrane [UNKNOWN] integral to membrane [IEA] plasma membrane [IMP]
Biological Process:	peptide metabolic process [IMP] proteolysis [IDA][IMP]
Molecular Function:	protein binding [UNKNOWN][IEA] metal ion binding [IEA] peptide binding [IDA][IMP] peptidase activity [UNKNOWN][IEA] metalloendopeptidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRSESQMDI TDINAPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA TYDDGICKSS  60
   61 DCIKSAARLI QNMDASAEPC TDFFKYACGG WLKRNVIPET SSRYSNFDIL RDELEVILKD 120
  121 VLQEPKTEDI VAVQKAKTLY RSCINESAID SRGGQPLLTL LPDIYGWPVA SQNWEQTYGT 180
  181 SWTAEKSIAQ LNSKYGKKVL INFFVGTDDK NSTQHIIHFD QPRLGLPSRD YYECTGIYKE 240
  241 ACTAYVDFMI SVARLIRQEQ RLPIDENQLS LEMNKVMELE KEIANATTKP EDRNDPMLLY 300
  301 NKMTLAKLQN NFSLEINGKP FSWSNFTNEI MSTVNINIQN EEEVVVYAPE YLTKLKPILT 360
  361 KYSPRDLQNL MSWRFIMDLV SSLSRNYKES RNAFRKALYG TTSETATWRR CANYVNGNME 420
  421 NAVGRLYVEA AFAGESKHVV EDLIAQIREV FIQTLDDLTW MDAETKKKAE EKALAIKERI 480
  481 GYPDDIISNE NKLNNEYLEL NYKEEEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA 540
  541 VVNAFYSSGR NQIVFPAGIL QPPFFSARQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD 600
  601 GDLVDWWTQQ SANNFKDQSQ CMVYQYGNFT WDLAGGQHLN GINTLGENIA DNGGIGQAYR 660
  661 AYQNYVKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP EYAVNSIKTD VHSPGNFRII 720
  721 GTLQNSAEFA DAFHCRKNSY MNPERKCRVW

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: NEP_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: