Protein Overview: RPGF4_RAT

General Information:
Name(s) found:	RPGF4_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|4115911\|gb\|AAD03423.1\| cAMP-regulated guanine nucleotide exchange factor II [Rattus norvegicus] [NCBI NR] gi\|32171371\|sp\|Q9Z1C7.1\|RPGF4_RAT RecName: Full=Rap guanine nucleotide exchange factor 4; AltName: Full=cAMP-regulated guanine nucleotide exchange factor II; Short=cAMP-GEFII; AltName: Full=Exchange factor directly activated by cAMP 2; AltName: Full=Epac [NCBI NR] Rap guanine nucleotide exchange factor 4 (Fragment) OS=Rattus norvegicus GN=Rapgef4 PE=2 SV=1 [Swiss-Prot] (Q9Z1C7) RAP guanine-nucleotide-exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (Fragment) [Swiss-Prot] Ensembl_locations(Chr-bp):3-165714066 cAMP-regulated guanine nucleotide exchange factor II [hmr_yeast5_DM3-1_pombe.fasta] RAP guanine-nucleotide-exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2)gi\|4115911\|gb\|AAD03423.1\| cAMP-regulated guanine nucleotide exchange factor II [Rattus nor [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Rap guanine nucleotide exchange factor 4 (Fragment) [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Rap guanine nucleotide exchange factor 4 [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cAMP-regulated guanine nucleotide exchange factor II [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 RAP GUANINE-NUCLEOTIDE-EXCHANGE FACTOR 4 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Rap guanine nucleotide exchange factor 4 (Fragment) OS=Rattus norvegicus GN=Rapgef4 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	436 amino acids
Gene Ontology:
Cellular Component:	excitatory synapse [IDA] protein complex [IDA] intracellular [IEA] plasma membrane [IDA] cAMP-dependent protein kinase complex [IEA] photoreceptor outer segment [IDA] dendrite [IDA] cytoplasm [IEA] dendritic spine [IDA] cytosol [UNKNOWN][IEA] photoreceptor inner segment [IDA] basolateral plasma membrane [IDA] apical plasma membrane [IDA] axon [IDA]
Biological Process:	regulation of dendrite development [IMP] heart development [IEP] insulin secretion [UNKNOWN][IEA] regulation of protein amino acid phosphorylation [IEA] signal transduction [IDA][IEA] regulation of small GTPase mediated signal transduction [IEA] negative regulation of synaptic transmission [IDA] calcium ion-dependent exocytosis [UNKNOWN][IEA] positive regulation of smooth muscle cell migration [IDA] regulation of exocytosis [UNKNOWN][IEA] cAMP-mediated signaling [UNKNOWN][IEA]
Molecular Function:	protein binding [IPI] guanyl-nucleotide exchange factor activity [UNKNOWN][IDA][IEA] Ras guanyl-nucleotide exchange factor activity [ISS] cAMP binding [IDA][ISS] cAMP-dependent protein kinase regulator activity [IEA] protein complex binding [IDA] Ras GTPase binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVIRLVLQWA AMYGDLLQED DVAMAFLEEF YVSVSDDARM MVAFKEQLAE LEKTVKQISE  60
   61 DAKAPQKKHK VLLQQFNTGD ERAQKRQPIR GSDEVLFKVY CIDHTDTTIR VPVAASVKEV 120
  121 ISAVADKLGS GEGLIIVKMN SGGEKVVLKP NDVSVFTTLT INGRLFACPR EQFDSLTPLP 180
  181 EQEGPTTGTV GTFELMSSKD LAYQMTTYDW ELFNCVLELE LIYHTFGRHN FKKTTANLDL 240
  241 FLRRFNEIQF WVVTEICLCS QLSKRVQLLK KCIKIAAHCK EYKNLNSFFG IVMGLSNVAE 300
  301 SRLALTWEKL PSKFKKFYAE FESLMDPSRN HKAYRLTAAK LEPPLIPFMP LLIKDMTFTH 360
  361 EGNKTFIDNL VNFEKMRMIA NTARTVRYYR SQPFNPDAAQ ANKNHQDVRS YVRQLNVIDN 420
  421 QRTLSQMSHR LEPRRP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: RPGF4_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: