Protein Overview: NR1H4_RAT

General Information:
Name(s) found:	NR1H4_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|868032\|gb\|AAC52205.1\| farnesoid X activated receptor [NCBI NR] gi\|21263799\|sp\|Q62735.1\|NR1H4_RAT RecName: Full=Bile acid receptor; AltName: Full=Farnesoid X-activated receptor; AltName: Full=Farnesol receptor HRR-1; AltName: Full=Nuclear receptor subfamily 1 group H member 4; AltName: Full=Retinoid X receptor-interac [NCBI NR] gi\|149067253\|gb\|EDM16986.1\| nuclear receptor subfamily 1, group H, member 4, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|11120690\|ref\|NP_068513.1\| nuclear receptor subfamily 1, group H, member 4 [Rattus norvegicus] [NCBI NR] pir\|\|A56918 farnesoid x-activated receptor - rat [NCBI NR] (Q62735) Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) [Swiss-Prot] Bile acid receptor OS=Rattus norvegicus GN=Nr1h4 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):7-17535448 Bile acid receptor [hmr_yeast5_DM3-1_pombe.fasta] farnesoid X activated receptor [HMR_022704-rand.fasta] farnesoid X activated receptor [Rattus norvegicus]gi\|21263799\|sp\|Q62735\|NRH4_RAT Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)gi\|868032\|gb\|AAC52205 [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Bile acid receptor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_021745) farnesoid X activated receptor [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] nuclear receptor subfamily 1, group H, member 4 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] nuclear receptor subfamily 1, group H, member 4, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) [nr-271106-contam.fasta] farnesoid X activated receptor [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Nr1h4 Bile acid receptor [rat-ipi-250309-contam.fasta] Bile acid receptor OS=Rattus norvegicus GN=Nr1h4 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	469 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter [IMP] regulation of carbohydrate metabolic process [IMP] response to glucose stimulus [IEP] gut development [IEP] regulation of transcription, DNA-dependent [IEA] response to lipopolysaccharide [IEP] positive regulation of transcription from RNA polymerase II promoter [IMP] bile acid metabolic process [UNKNOWN][IDA] regulation of transcription from RNA polymerase II promoter [UNKNOWN]
Molecular Function:	zinc ion binding [IEA] bile acid binding [IDA] double-stranded DNA binding [IDA] peptide binding [IDA] sequence-specific DNA binding [UNKNOWN][IEA] receptor activity [IDA] retinoid X receptor binding [UNKNOWN] DNA binding [IDA] transcription factor activity [UNKNOWN][IEA] protein binding [UNKNOWN] metal ion binding [IEA] steroid hormone receptor activity [IDA] transcription repressor activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLIGPSHLQ ATDEFALSEN LFGVLTEHAA GPLGQNLDLE SYSPYNNVQF PQVQPQISSS  60
   61 SYYSNLGFYP QQPEDWYSPG LYELRRMPTE SVYQGETEVS EMPVTKKPRM AASSAGRIKG 120
  121 DELCVVCGDR ASGYHYNALT CEGCKGFFRR SITKNAVYKC KNGGNCVMDM YMRRKCQDCR 180
  181 LRKCREMGML AECLLTEIQC KSKRLRKNVK QHADQTVNED SEGRDLRQVT STTKLCREKT 240
  241 ELTVDQQTLL DYIMDSYSKQ RMPQEITNKI LKEEFSAEEN FLILTEMATS HVQILVEFTK 300
  301 RLPGFQTLDH EDQIALLKGS AVEAMFLRSA EIFNKKLPAG HADLLEERIR KSGISDEYIT 360
  361 PMFSFYKSVG ELKMTQEEYA LLTAIVILSP DRQYIKDREA VEKLQEPLLD VLQKLCKIYQ 420
  421 PENPQHFACL LGRLTELRTF NHHHAEMLMS WRVNDHKFTP LLCEIWDVQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: NR1H4_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: