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Protein Overview: PA2GA_RAT

General Information:
Name(s) found: PA2GA_RAT [Swiss-Prot]
Description(s) found:
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  • gi|220858|dbj|BAA00410.1| phospholipase A2 precursor [Rattus norvegicus] [NCBI NR]
  • gi|149024393|gb|EDL80890.1| phospholipase A2, group IIA (platelets, synovial fluid), isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|129493|sp|P14423.2|PA2GA_RAT RecName: Full=Phospholipase A2, membrane associated; AltName: Full=Phosphatidylcholine 2-acylhydrolase; AltName: Full=Group IIA phospholipase A2; AltName: Full=GIIC sPLA2; Flags: Precursor [NCBI NR]
  • pir||A33394 phospholipase A2 (EC 3.1.1.4) precursor (version 1) - rat [NCBI NR]
  • Phospholipase A2, membrane associated OS=Rattus norvegicus GN=Pla2g2a PE=1 SV=2 [Swiss-Prot]
  • (P14423) Phospholipase A2, membrane associated precursor (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Group IIA phospholipase A2) (GIIC sPLA2) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None Phospholipase A2, membrane associated precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • phospholipase A2 (EC 3.1.1.4) precursor (version 1) - ratgi|220858|dbj|BAA00410.1| phospholipase A2 precursor [Rattus norvegicus]gi|129493|sp|P14423|PA2A_RAT Phospholipase A2, membrane associated precursor (Phosphatidylcholine 2-acylhydrolase) (Group II [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Phospholipase A2, membrane associated precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Phospholipase A2, membrane associated precursor (Phosphatidylcholine 2-acylhydrolase) (Group IIA phospholipase A2) (GIIC sPLA2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phospholipase A2 precursor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phospholipase A2, group IIA (platelets, synovial fluid), isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Pla2g2a Phospholipase A2, membrane associated [rat-ipi-250309-contam.fasta]
  • Phospholipase A2, membrane associated OS=Rattus norvegicus GN=Pla2g2a [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 146 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IEA]
    secretory granule [IDA]
    mitochondrion [UNKNOWN][IEA]
    membrane [IEA]
    endoplasmic reticulum [UNKNOWN][IEA]
    Biological Process: negative regulation of cell proliferation [UNKNOWN]
    phosphatidic acid metabolic process [UNKNOWN][IEA]
    lipid catabolic process [TAS]
    negative regulation of epithelial cell proliferation [UNKNOWN][IEA]
    somatic stem cell maintenance [UNKNOWN][IEA]
    phospholipid metabolic process [UNKNOWN][IDA]
    regulation of epithelial cell proliferation [UNKNOWN]
    regulation of cell proliferation [UNKNOWN]
    Molecular Function: phospholipase A2 activity [UNKNOWN][TAS]
    calcium-dependent phospholipase A2 activity [IDA]
    calcium ion binding [IEA]
    phospholipid binding [UNKNOWN][IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVLLLLAVV IMAFGSIQVQ GSLLEFGQMI LFKTGKRADV SYGFYGCHCG VGGRGSPKDA  60
   61 TDWCCVTHDC CYNRLEKRGC GTKFLTYKFS YRGGQISCST NQDSCRKQLC QCDKAAAECF 120
  121 ARNKKSYSLK YQFYPNKFCK GKTPSC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] PSI-BLAST 32.69897 Phospholipase A2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phospholipase A2 activity
    		•  5.6430968678228 bayes_pls_golite062009
  • phospholipase activity
    		•  5.38445724291842 bayes_pls_golite062009
  • calcium-dependent phospholipase A2 activity
    		•  4.05813159633475 bayes_pls_golite062009
  • lipase activity
    		•  3.51338748073942 bayes_pls_golite062009
  • cell surface binding
    		•  3.03976629465117 bayes_pls_golite062009
  • carboxylesterase activity
    		•  2.68079964970429 bayes_pls_golite062009
  • receptor binding
    		•  2.23831898285432 bayes_pls_golite062009
  • binding
    		•  1.6033670102211 bayes_pls_golite062009
  • protein binding
    		•  1.47445022237761 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.42015803437458 bayes_pls_golite062009
  • hydrolase activity
    		•  1.32355620269997 bayes_pls_golite062009
  • heparin binding
    		•  1.06811660027805 bayes_pls_golite062009
  • catalytic activity
    		•  0.975181414554529 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.453108206649759 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle