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Protein Overview: GCH1_RAT

General Information:
Name(s) found: GCH1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|204537|gb|AAA41299.1| GTP cyclohydrolase I [NCBI NR]
  • gi|149033547|gb|EDL88345.1| GTP cyclohydrolase 1 [Rattus norvegicus] [NCBI NR]
  • gi|13242245|ref|NP_077332.1| GTP cyclohydrolase 1 [Rattus norvegicus] [NCBI NR]
  • gi|121061|sp|P22288.1|GCH1_RAT RecName: Full=GTP cyclohydrolase 1; AltName: Full=GTP cyclohydrolase I; Short=GTP-CH-I; Flags: Precursor [NCBI NR]
  • pir||A39080 GTP cyclohydrolase I (EC 3.5.4.16) precursor - rat [NCBI NR]
  • GTP cyclohydrolase 1 OS=Rattus norvegicus GN=Gch1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):15-23279669 GTP cyclohydrolase I precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • GTP cyclohydrolase 1 [HMR_022704-rand.fasta]
  • GTP cyclohydrolase 1 [Rattus norvegicus]gi|111730|pir||A39080 GTP cyclohydrolase I (EC 3.5.4.16) precursor - ratgi|204537|gb|AAA41299.1| GTP cyclohydrolase Igi|121061|sp|P22288|GCH1_RAT GTP cyclohydrolase I precursor (GTP-CH-I) [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 GTP cyclohydrolase I precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_024356) GTP cyclohydrolase 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • GTP cyclohydrolase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • GTP cyclohydrolase 1 precursor (GTP cyclohydrolase I) (GTP-CH-I) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • GTP cyclohydrolase I [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 GTP CYCLOHYDROLASE I PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • GTP cyclohydrolase I precursor (GTP-CH-I) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Gch1 GTP cyclohydrolase 1 [rat-ipi-250309-contam.fasta]
  • GTP cyclohydrolase 1 OS=Rattus norvegicus GN=Gch1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 241 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    soluble fraction [IDA]
    cytoplasm [UNKNOWN][IEA]
    cytosol [UNKNOWN][IEA]
    cytoplasmic vesicle [UNKNOWN][IEA]
    protein complex [UNKNOWN][IDA]
    cellular_component [ND]
    Biological Process: dopamine biosynthetic process [UNKNOWN][IEA]
    pteridine and derivative biosynthetic process [UNKNOWN]
    protein complex assembly [IDA]
    response to interferon-gamma [UNKNOWN][IEA]
    GTP catabolic process [UNKNOWN][IEA]
    protein homooligomerization [UNKNOWN][IDA]
    negative regulation of blood pressure [IMP]
    protein heterooligomerization [IDA]
    vasodilation [IMP]
    tetrahydrofolate biosynthetic process [IEA]
    regulation of blood pressure [UNKNOWN]
    catecholamine biosynthetic process [UNKNOWN]
    response to pain [IDA]
    neuromuscular process controlling posture [UNKNOWN][IEA]
    tetrahydrobiopterin biosynthetic process [UNKNOWN][TAS]
    positive regulation of nitric-oxide synthase activity [UNKNOWN][IEA]
    dihydrobiopterin metabolic process [IDA]
    induction of apoptosis [IEP]
    regulation of lung blood pressure [UNKNOWN][IEA]
    response to lipopolysaccharide [UNKNOWN][IEA]
    response to tumor necrosis factor [UNKNOWN][IEA]
    Molecular Function: nucleotide binding [IEA]
    GTP binding [UNKNOWN][IDA]
    zinc ion binding [UNKNOWN][IDA]
    protein binding [UNKNOWN][IDA][IPI]
    protein homodimerization activity [UNKNOWN][IEA]
    coenzyme binding [IDA]
    GTP cyclohydrolase I activity [UNKNOWN][IDA]
    calcium ion binding [IDA]
    hydrolase activity [IEA]
    GTP-dependent protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKPRGVRCT NGFPERELPR PGASRPAEKS RPPEAKGAQP ADAWKAGRPR SEEDNELNLP  60
   61 NLAAAYSSIL RSLGEDPQRQ GLLKTPWRAA TAMQFFTKGY QETISDVLND AIFDEDHDEM 120
  121 VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 180
  181 AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 240
  241 S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle