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Protein Overview: NCOA2_RAT

General Information:
Name(s) found: NCOA2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|4581053|gb|AAD24587.1|AF136943_1 transcriptional intermediary factor 2 [Rattus norvegicus] [NCBI NR]
  • gi|13929174|ref|NP_114010.1| nuclear receptor coactivator 2 [Rattus norvegicus] [NCBI NR]
  • gi|13124334|sp|Q9WUI9.1|NCOA2_RAT RecName: Full=Nuclear receptor coactivator 2; Short=NCoA-2; AltName: Full=Transcriptional intermediary factor 2 [NCBI NR]
  • Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 [Swiss-Prot]
  • (Q9WUI9) Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):5-4061369;5-4061369 Nuclear receptor coactivator 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • nuclear receptor coactivator 2 [HMR_022704-rand.fasta]
  • nuclear receptor coactivator 2 [Rattus norvegicus]gi|4581053|gb|AAD24587.1| transcriptional intermediary factor 2 [Rattus norvegicus]gi|13124334|sp|Q9WUI9|NCO2_RAT Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) [nrdb_11152004_Chlamydomonas]
  • (NM_031822) nuclear receptor coactivator 2 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Tax_Id=10116 Nuclear receptor coactivator 2 [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta]
  • Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • nuclear receptor coactivator 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • transcriptional intermediary factor 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 NUCLEAR RECEPTOR COACTIVATOR 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 1465 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA][IEA]
    cytoplasm [UNKNOWN][IEA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    signal transduction [IEA]
    cerebellum development [IEP]
    regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    Molecular Function: ligand-dependent nuclear receptor binding [UNKNOWN]
    protein binding [UNKNOWN]
    transcription coactivator activity [UNKNOWN][IEA]
    transcription regulator activity [IEA]
    ligand-dependent nuclear receptor transcription coactivator activity [UNKNOWN]
    chromatin binding [UNKNOWN][IEA]
    thyroid hormone receptor coactivator activity [UNKNOWN][IEA]
    transcription repressor activity [UNKNOWN][IEA]
    nuclear hormone receptor binding [IEA]
    signal transducer activity [IEA]
    receptor binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA ELIFANFNDI  60
   61 DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS DVSSTGQGVI DKDALGPMML 120
  121 EALDGFFFVV NLEGNVVFVS ENVTQYLRYN QEELMNKSVY SILHVGDHTE FVKNLLPKSM 180
  181 VNGGSWTGEP PRRNSHTFNC RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE 240
  241 EGEDKQSCLI CVARRVPMKE RPALPSSESF TTRQDLQGKI TFLDTSTMRD AMKPGWEDLV 300
  301 RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ TKSKLIRSQT 360
  361 TNEPQLVISI HMLHREQNVC VMNPDLTGQA MGKPLSPMSS SSPARQAMCS GNPGQDVALG 420
  421 SNMNFPMNGP REQMSMPMGR FGGSGGMNHV SGMQATTPQG SNYALKMNSP SQSSPGLNPG 480
  481 QPSSVLSPRH RMSPGVAGSP RVPPSQFSPA GSLHSPAGVC SSTGNSHSYT NSSLNALQAL 540
  541 SEGHGVSLGP SLASPDLKMG NSQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 600
  601 QASCHPEEQK RPNDSSMPQA ASEDRAEGHS RLHESKGQTK LLQLLTTKSD QMEPSPLPSS 660
  661 LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP VDLAKLTAEA TGKELNQESS 720
  721 GTAPGSEVTV KQEPASPKKK ENALLRYLLD KDDTKDIGLP EITPKLERLD SKTDPASNTK 780
  781 LIAMKTVKEE VSFEPSDQPG SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII 840
  841 NDLMQLTADS SPVTPVGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 900
  901 PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRSSMP SGEWAPQSPA 960
  961 VRVTCAATTG AMNRPIQGGM IRNPTASIPM RANSQPGQRQ MLQPQVMNIG PSELEMNMGG1020
 1021 PQYNQQQAPP NQTAPWPESI LPIDQASFGS QNRHPFGSSP DDLLCPHPAA ESPSDEGALL1080
 1081 DQLYLALRNF DGLEEIDRAL GIPELVSQSQ AVDPEQFSSQ ESSMMLEQKP PVFPQQYASQ1140
 1141 TQMAQGSYNP MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ1200
 1201 QNRQPLMNQI SGVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR QMHQQQQVQQ1260
 1261 RTLMMRGQGL NMTPSMVAPT GLPAAMSNPR IPQANAQQFP FPPNYGISQQ PDPGFTGATT1320
 1321 PQSPLMSPRM AHTQSPMMQQ SQANPAYQPA SDINGWAQGS MGGNSMFSQQ SPPHFGQQAN1380
 1381 TSMYNNNMNI NVSMATNTAG LSNMNQMTGQ MSMTSVTSVP TSGLSSMGPE QVNDPALRGS1440
 1441 SLFTTNQLPG MDMIKQEGDG SRKYC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle