Protein Overview: CBLB_RAT

General Information:
Name(s) found:	CBLB_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|81866807\|sp\|Q8K4S7.1\|CBLB_RAT RecName: Full=E3 ubiquitin-protein ligase CBL-B; AltName: Full=Signal transduction protein CBL-B; AltName: Full=SH3-binding protein CBL-B; AltName: Full=Casitas B-lineage lymphoma proto-oncogene b [NCBI NR] gi\|29789319\|ref\|NP_598285.1\| Cas-Br-M (murine) ecotropic retroviral transforming sequence b [Rattus norvegicus] [NCBI NR] gi\|21886624\|dbj\|BAC05498.1\| Cbl-b [Rattus norvegicus] [NCBI NR] E3 ubiquitin-protein ligase CBL-B OS=Rattus norvegicus GN=Cblb PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):11-38503465 Cbl-b [hmr_yeast5_DM3-1_pombe.fasta] Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic retroviral transforming sequence b [HMR_022704-rand.fasta] Cas-Br-M (murine) ectropic retroviral transforming sequence b [Rattus norvegicus]gi\|21886624\|dbj\|BAC05498.1\| Cbl-b [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 E3 ubiquitin-protein ligase CBL-B [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Cbl-b [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] E3 ubiquitin-protein ligase CBL-B (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Casitas B-lineage lymphoma b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Cbl-b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 CBL-B [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Cas-Br-M (murine) ecotropic retroviral transforming sequence b [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Cblb E3 ubiquitin-protein ligase CBL-B [rat-ipi-250309-contam.fasta] E3 ubiquitin-protein ligase CBL-B OS=Rattus norvegicus GN=Cblb [011711_HMR.fasta] E3 ubiquitin-protein ligase CBL-B OS=Rattus norvegicus GN=Cblb PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	938 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA] cytoplasm [IEA] membrane raft [IDA]
Biological Process:	response to gravity [IEP] immune response [UNKNOWN] intracellular signaling pathway [UNKNOWN] negative regulation of T cell receptor signaling pathway [UNKNOWN] positive regulation of T cell anergy [UNKNOWN] signal transduction [IDA] T cell activation [UNKNOWN] positive regulation of protein catabolic process [UNKNOWN] cell surface receptor linked signaling pathway [IEA] negative regulation of alpha-beta T cell proliferation [UNKNOWN] response to hormone stimulus [IEP] response to protein stimulus [IEP]
Molecular Function:	protein kinase binding [IPI] zinc ion binding [IEA] protein binding [IEA] calcium ion binding [IEA] signal transducer activity [IEA] ligase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC  60
   61 QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 120
  121 AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF SHMLAEIKAI FPNGQFQGDN FRITKADAAE 180
  181 FWRKFFGDKT IVPWKVFRQC LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF 240
  241 QPWGSILRNW NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV 300
  301 TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH DHIKVTQEQY 360
  361 ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTAW QESDGQGCPF CRCEIKGTEP 420
  421 IIVDPFDPRD EGSRCCSIID PFSIPMLDLD DDDDREESLM MNRLASVRKC TDRQNSPVTS 480
  481 PGSSPLAQRR KPQPDPLQIP HLSLPPVPPR LDLIQKGIVR SPCGSPTGSP KSSPCMVRKQ 540
  541 DKPLPAPPPP LRDPPPPPER PPPIPPDSRL SRHFHHGESV PSRDQPMPLE AWCPRDAFGT 600
  601 NQVMGCRILG DGSPKPGVTA NSNLNGRHSR MGSDQVLMRK HRRHDLPSEG AKVFSNGHLA 660
  661 PEEYDVPPRL SPPPPVTALL PSIKCTGPIA NCLSEKTRDT VEEDDDEYKI PSSHPVSLNS 720
  721 QPSHCHNVKP PVRSCDNGHC ILNGTHGTPS EMKKSNIPDL GIYLKGEDAF DALPPSLPPP 780
  781 PPPARHSLIE HSKPPGSSSR PSSGQDLFLL PSDPFFDPAS GQVPLPPARR APGDGVKSNR 840
  841 ASQDYDQLPS SSDGSQAPAR PPKPRPRRTA PEIHHRKPHG PEAALENVDA KIAKLMGEGY 900
  901 AFEEVKRALE IAQNNLEVAR SILREFAFPP PVSPRLNL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: CBLB_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: