Protein Overview: GRM5_RAT

General Information:
Name(s) found:	GRM5_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|171346166\|gb\|ACB45671.1\| metabotropic glutamate receptor 5b [Rattus norvegicus] [NCBI NR] gi\|149069038\|gb\|EDM18590.1\| glutamate receptor, metabotropic 5, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|1170947\|sp\|P31424.2\|GRM5_RAT RecName: Full=Metabotropic glutamate receptor 5; Short=mGluR5; Flags: Precursor [NCBI NR] Metabotropic glutamate receptor 5 precursor (mGluR5) - Rattus norvegicus (Rat) [Swiss-Prot] Metabotropic glutamate receptor 5 OS=Rattus norvegicus GN=Grm5 PE=1 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):1-140589623;1-140589623 Splice isoform 2 of P31424 [hmr_yeast5_DM3-1_pombe.fasta] Metabotropic glutamate receptor 5 precursor (mGluR5) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 2 of Metabotropic glutamate receptor 5 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] metabotropic glutamate receptor 5b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] glutamate receptor, metabotropic 5, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF METABOTROPIC GLUTAMATE RECEPTOR 5 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Grm5 Isoform 2 of Metabotropic glutamate receptor 5 [rat-ipi-250309-contam.fasta] Isoform 2 of Metabotropic glutamate receptor 5 OS=Rattus norvegicus GN=Grm5 [011711_HMR.fasta] Glutamate receptor, metabotropic 5, isoform CRA_a OS=Rattus norvegicus GN=Grm5 [011711_HMR.fasta] Glutamate receptor, metabotropic 5, isoform CRA_a OS=Rattus norvegicus GN=Grm5 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	1203 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] postsynaptic density [IDA] cytoplasm [UNKNOWN][IEA] postsynaptic membrane [TAS] dendritic shaft [IDA] dendritic spine [IDA] integral to membrane [IEA] plasma membrane [UNKNOWN][IEA]
Biological Process:	negative regulation of locomotion [IDA] signal transduction [IEA] regulation of transcription, DNA-dependent [IDA] synaptic transmission [IMP] protein amino acid phosphorylation [IDA] activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IDA][TAS] learning [UNKNOWN][IEA] activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway [TAS] activation of MAPKKK activity [IDA] desensitization of G-protein coupled receptor protein signaling pathway [IDA] locomotory behavior [UNKNOWN][IEA] phosphoinositide-mediated signaling [TAS] regulation of long-term neuronal synaptic plasticity [UNKNOWN] elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger [TAS] positive regulation of long-term neuronal synaptic plasticity [IDA]
Molecular Function:	G-protein coupled receptor activity [IEA] calmodulin binding [TAS] protein binding [UNKNOWN][IPI] PDZ domain binding [TAS] PLC activating metabotropic glutamate receptor activity [TAS] receptor activity [IEA] A2A adenosine receptor binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD KVHERKCGAV  60
   61 REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW HSAVALEQSI EFIRDSLISS 120
  121 EEEEGLVRCV DGSSSFRSKK PIVGVIGPGS SSVAIQVQNL LQLFNIPQIA YSATSMDLSD 180
  181 KTLFKYFMRV VPSDAQQARA MVDIVKRYNW TYVSAVHTEG NYGESGMEAF KDMSAKEGIC 240
  241 IAHSYKIYSN AGEQSFDKLL KKLRSHLPKA RVVACFCEGM TVRGLLMAMR RLGLAGEFLL 300
  301 LGSDGWADRY DVTDGYQREA VGGITIKLQS PDVKWFDDYY LKLRPETNLR NPWFQEFWQH 360
  361 RFQCRLEGFA QENSKYNKTC NSSLTLRTHH VQDSKMGFVI NAIYSMAYGL HNMQMSLCPG 420
  421 YAGLCDAMKP IDGRKLLDSL MKTNFTGVSG DMILFDENGD SPGRYEIMNF KEMGKDYFDY 480
  481 INVGSWDNGE LKMDDDEVWS KKNNIIRSVC SEPCEKGQIK VIRKGEVSCC WTCTPCKENE 540
  541 YVFDEYTCKA CQLGSWPTDD LTGCDLIPVQ YLRWGDPEPI AAVVFACLGL LATLFVTVIF 600
  601 IIYRDTPVVK SSSRELCYII LAGICLGYLC TFCLIAKPKQ IYCYLQRIGI GLSPAMSYSA 660
  661 LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFILI CIQLGIIVAL FIMEPPDIMH 720
  721 DYPSIREVYL ICNTTNLGVV TPLGYNGLLI LSCTFYAFKT RNVPANFNEA KYIAFTMYTT 780
  781 CIIWLAFVPI YFGSNYKIIT MCFSVSLSAT VALGCMFVPK VYIILAKPER NVRSAFTTST 840
  841 VVRMHVGDGK SSSAASRSSS LVNLWKRRGS SGETLRYKDR RLAQHKSEIE CFTPKGSMGN 900
  901 GGRATMSSSN GKSVTWAQNE KSTRGQHLWQ RLSVHINKKE NPNQTAVIKP FPKSTENRGP 960
  961 GAAAGGGSGP GVAGAGNAGC TATGGPEPPD AGPKALYDVA EAEESFPAAA RPRSPSPIST1020
 1021 LSHLAGSAGR TDDDAPSLHS ETAARSSSSQ GSLMEQISSV VTRFTANISE LNSMMLSTAA1080
 1081 TPGPPGTPIC SSYLIPKEIQ LPTTMTTFAE IQPLPAIEVT GGAQGATGVS PAQETPTGAE1140
 1141 SAPGKPDLEE LVALTPPSPF RDSVDSGSTT PNSPVSESAL CIPSSPKYDT LIIRDYTQSS1200
 1201 SSL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: GRM5_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: