Protein Overview: AT2B2_RAT

General Information:
Name(s) found:	AT2B2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|14286100\|sp\|P11506.2\|AT2B2_RAT RecName: Full=Plasma membrane calcium-transporting ATPase 2; Short=PMCA2; AltName: Full=Plasma membrane calcium ATPase isoform 2; AltName: Full=Plasma membrane calcium pump isoform 2 [NCBI NR] (P11506) Plasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2) [Swiss-Prot] Plasma membrane calcium-transporting ATPase 2 OS=Rattus norvegicus GN=Atp2b2 PE=1 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):None Splice isoform WB of P11506 [hmr_yeast5_DM3-1_pombe.fasta] Plasma membrane calcium-transporting ATPase 2 (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform WB of Plasma membrane calcium-transporting ATPase 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Plasma membrane calcium-transporting ATPase 2 (PMCA2) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Atp2b2 Isoform WB of Plasma membrane calcium-transporting ATPase 2 [rat-ipi-250309-contam.fasta] Isoform 1 of Plasma membrane calcium-transporting ATPase 2 OS=Rattus norvegicus GN=Atp2b2 [011711_HMR.fasta] Plasma membrane calcium-transporting ATPase 2 OS=Rattus norvegicus GN=Atp2b2 PE=2 SV=2 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	1243 amino acids
Gene Ontology:
Cellular Component:	dendrite [IDA] cytoplasm [UNKNOWN][ISS] membrane [IEA] membrane raft [IDA] microsome [UNKNOWN] cilium [UNKNOWN] integral to membrane [IEA] endoplasmic reticulum [UNKNOWN] neuronal cell body [UNKNOWN][IDA] plasma membrane [UNKNOWN][ISS][TAS] apical plasma membrane [UNKNOWN][IDA]
Biological Process:	auditory receptor cell stereocilium organization [UNKNOWN] inner ear development [UNKNOWN] locomotion [UNKNOWN] regulation of cell size [UNKNOWN] positive regulation of calcium ion transport [UNKNOWN] lactation [UNKNOWN] sensory perception of sound [UNKNOWN][ISS] cation transport [IEA] locomotory behavior [UNKNOWN] cGMP metabolic process [UNKNOWN] otolith mineralization [UNKNOWN] neural retina development [IEP] calcium ion transport [UNKNOWN][IEA] regulation of synaptic plasticity [UNKNOWN] detection of mechanical stimulus involved in sensory perception of sound [UNKNOWN] cerebellar granule cell differentiation [UNKNOWN] serotonin metabolic process [UNKNOWN] inner ear receptor cell differentiation [UNKNOWN] cerebellar Purkinje cell differentiation [UNKNOWN] cerebellum development [UNKNOWN] neuron differentiation [UNKNOWN][ISS] synapse organization [UNKNOWN] cell morphogenesis [UNKNOWN] metabolic process [IEA] brain development [IEP] ATP biosynthetic process [IEA] organelle organization [UNKNOWN] cellular calcium ion homeostasis [UNKNOWN] cerebellar Purkinje cell layer morphogenesis [UNKNOWN] inner ear morphogenesis [UNKNOWN] neuromuscular process controlling balance [UNKNOWN]
Molecular Function:	protein C-terminus binding [UNKNOWN][ISS] calcium-transporting ATPase activity [UNKNOWN][IDA][IEA][ISS][TAS] nucleotide binding [IEA] calcium-dependent ATPase activity [UNKNOWN] ATP binding [UNKNOWN][IDA][IEA][ISS] calmodulin binding [UNKNOWN][IEA][ISS] protein binding [UNKNOWN] catalytic activity [IEA] metal ion binding [IEA] calcium ion binding [UNKNOWN][ISS] PDZ domain binding [UNKNOWN][IPI][ISS] hydrolase activity [IEA] hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL  60
   61 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 120
  121 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 180
  181 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 240
  241 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 300
  301 KKGVKKGDGL QLPAADGAAP ANAAGSANAS LVNGKMQDGS ADSSQSKAKQ QDGAAAMEMQ 360
  361 PLKSAEGGDA DDKKKANMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 420
  421 FVVNKKPWLT ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 480
  481 VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NAKTLELLVN 540
  541 AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL RQDYEPVRSQ MPEEKLYKVY 600
  601 TFNSVRKSMS TVIKMPDESF RMYSKGASEI VLKKCCKILS GAGEPRVFRP RDRDEMVKKV 660
  661 IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 720
  721 QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 780
  781 IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 840
  841 GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 900
  901 QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 960
  961 YQLTLIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER1020
 1021 NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV1080
 1081 IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ1140
 1141 IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS1200
 1201 SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: AT2B2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: