Protein Overview: CRFR1_RAT

General Information:
Name(s) found:	CRFR1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|544101\|sp\|P35353.1\|CRFR1_RAT RecName: Full=Corticotropin-releasing factor receptor 1; Short=CRF-R; Short=CRF1; AltName: Full=Corticotropin-releasing hormone receptor 1; Short=CRH-R 1; Flags: Precursor [NCBI NR] gi\|457615\|gb\|AAA16441.1\| corticotropin-releasing factor receptor [NCBI NR] pir\|\|I58144 corticotropin-releasing factor receptor - rat [NCBI NR] gi\|149054477\|gb\|EDM06294.1\| corticotropin releasing hormone receptor 1 [Rattus norvegicus] [NCBI NR] gi\|13591892\|ref\|NP_112261.1\| corticotropin releasing hormone receptor 1 [Rattus norvegicus] [NCBI NR] gi\|1354490\|gb\|AAC53519.1\| corticotropin releasing factor receptor [Rattus norvegicus] [NCBI NR] Corticotropin-releasing factor receptor 1 OS=Rattus norvegicus GN=Crhr1 PE=1 SV=1 [Swiss-Prot] (P35353) Corticotropin releasing factor receptor 1 precursor (CRF-R) (CRF1) (Corticotropin-releasing hormone receptor 1) (CRH-R 1) [Swiss-Prot] Ensembl_locations(Chr-bp):10-91735410 Corticotropin releasing factor receptor 1 precursor [hmr_yeast5_DM3-1_pombe.fasta] corticotropin releasing hormone receptor 1; corticotropin releasing hormone 1; Corticotrophin releasing hormone receptor 1 [HMR_022704-rand.fasta] corticotropin releasing hormone receptor 1 [Rattus norvegicus]gi\|1354490\|gb\|AAC53519.1\| corticotropin releasing factor receptor [Rattus norvegicus]gi\|2143669\|pir\|\|I58144 corticotropin-releasing factor receptor - ratgi\|544101\|sp\|P35353\|CRF1_RAT Corticot [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Corticotropin-releasing factor receptor 1 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_030999) corticotropin releasing hormone 1; corticotropin releasing hormone receptor 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Tax_Id=10116 Corticotropin releasing factor receptor 1 precursor [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta] corticotropin releasing hormone receptor 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Corticotropin-releasing factor receptor 1 precursor (CRF-R) (CRF1) (Corticotropin-releasing hormone receptor 1) (CRH-R 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] corticotropin releasing factor receptor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] corticotropin-releasing factor receptor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Crhr1 Corticotropin-releasing factor receptor 1 [rat-ipi-250309-contam.fasta] Corticotropin-releasing factor receptor 1 OS=Rattus norvegicus GN=Crhr1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	415 amino acids
Gene Ontology:
Cellular Component:	dendrite [IDA] trans-Golgi network [IDA] apical part of cell [IDA] membrane [IDA][IEA] [NOT]dendritic spine [IDA] integral to membrane [IEA] vesicle [IDA] axon part [IDA] multivesicular body [IDA] neuronal cell body [IDA] [NOT]plasma membrane [IDA]
Biological Process:	neuroprotection [IMP] G-protein coupled receptor protein signaling pathway [IEA] signal transduction [IEA] negative regulation of appetite [IMP] G-protein signaling, coupled to cAMP nucleotide second messenger [IDA] visual learning [IMP] activation of adenylate cyclase activity by G-protein signaling pathway [IDA] activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger [IDA] memory [IMP] response to stress [UNKNOWN][IMP] behavior [UNKNOWN] elevation of cytosolic calcium ion concentration [IMP] eating behavior [IMP] neuropeptide signaling pathway [IDA] response to hypoxia [IMP] regulation of synaptic plasticity [IMP] behavioral response to pain [IMP]
Molecular Function:	G-protein coupled receptor activity [IDA][IEA][TAS] corticotrophin-releasing factor receptor activity [UNKNOWN][IEA] peptide binding [IPI] corticotropin-releasing hormone receptor activity [IDA] corticotropin-releasing hormone binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRRPQLRLV KALLLLGLNP VSTSLQDQRC ENLSLTSNVS GLQCNASVDL IGTCWPRSPA  60
   61 GQLVVRPCPA FFYGVRYNTT NNGYRECLAN GSWAARVNYS ECQEILNEEK KSKVHYHVAV 120
  121 IINYLGHCIS LVALLVAFVL FLRLRSIRCL RNIIHWNLIS AFILRNATWF VVQLTVSPEV 180
  181 HQSNVAWCRL VTAAYNYFHV TNFFWMFGEG CYLHTAIVLT YSTDRLRKWM FVCIGWGVPF 240
  241 PIIVAWAIGK LHYDNEKCWF GKRPGVYTDY IYQGPMILVL LINFIFLFNI VRILMTKLRA 300
  301 STTSETIQYR KAVKATLVLL PLLGITYMLF FVNPGEDEVS RVVFIYFNSF LESFQGFFVS 360
  361 VFYCFLNSEV RSAIRKRWRR WQDKHSIRAR VARAMSIPTS PTRVSFHSIK QSTAV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: CRFR1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: