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Protein Overview: PA24A_RAT

General Information:
Name(s) found: PA24A_RAT [Swiss-Prot]
Description(s) found:
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  • gi|1709551|sp|P50393.1|PA24A_RAT RecName: Full=Cytosolic phospholipase A2; Short=cPLA2; AltName: Full=Phospholipase A2 group IVA; Includes: RecName: Full=Phospholipase A2; AltName: Full=Phosphatidylcholine 2-acylhydrolase; Includes: RecName: Full=Lysophos [NCBI NR]
  • (P50393) Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] [Swiss-Prot]
  • Cytosolic phospholipase A2 OS=Rattus norvegicus GN=Pla2g4a PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):13-55695957 Cytosolic phospholipase A2 [hmr_yeast5_DM3-1_pombe.fasta]
  • phospholipase A2; PLA2 [Rattus sp.]gi|1709551|sp|P50393|PA4A_RAT Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase ] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Cytosolic phospholipase A2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase ] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 CYTOSOLIC PHOSPHOLIPASE A2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Pla2g4a Cytosolic phospholipase A2 [rat-ipi-250309-contam.fasta]
  • Cytosolic phospholipase A2 OS=Rattus norvegicus GN=Pla2g4a [011711_HMR.fasta]
  • Cytosolic phospholipase A2 OS=Rattus norvegicus GN=Pla2g4a PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 752 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDA]
    endoplasmic reticulum membrane [UNKNOWN]
    nucleus [IDA]
    perinuclear region of cytoplasm [IDA]
    cytoplasm [IDA]
    cytosol [UNKNOWN][IDA]
    cytoplasmic membrane-bounded vesicle [IEA]
    zymogen granule [IDA]
    Biological Process: response to vitamin D [IEP]
    positive regulation of vesicle fusion [IMP]
    positive regulation of cell proliferation [IMP]
    phospholipid catabolic process [IEA]
    decidualization [IMP]
    surfactant homeostasis [IMP]
    ovulation from ovarian follicle [IMP]
    response to heat [IEP]
    response to glucocorticoid stimulus [IEP]
    arachidonic acid metabolic process [IMP]
    positive regulation of bone mineralization [IEP]
    response to organic substance [IMP]
    positive regulation of prostaglandin biosynthetic process [IMP]
    metabolic process [IEA]
    positive regulation of inflammatory response [IMP]
    response to hydrogen peroxide [IEP]
    aging [IEP]
    response to hormone stimulus [IEP]
    regulation of cell proliferation [UNKNOWN]
    luteolysis [IEP]
    response to methylmercury [IEP]
    response to calcium ion [IMP]
    lipid catabolic process [IEA]
    positive regulation of apoptosis [IMP]
    response to lithium ion [IEP]
    response to lipopolysaccharide [IEP]
    positive regulation of fever [IEP]
    response to organic nitrogen [IEP]
    Molecular Function: phospholipase A2 activity [TAS]
    lysophospholipase activity [IEA]
    calcium-dependent phospholipase A2 activity [IDA]
    phospholipase activity [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFIDPYQHI IVEHQYSHKF TVVVLRATKV TKGTFGDMLD TPDPYVELFI STTPDSRKRT  60
   61 RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE TLGTATFPVS SMKVGEKKEV 120
  121 PFIFNQVTEM ILEMSLEVCS CPDLRFSMAL CDQEKTFRRQ RKENIKENMK KLLGPKKSEG 180
  181 LYSTRDVPVV AILGSGGGFR AMVGFSGVMK ALYESGILDC ATYVAGLSGS TWYMSTLYSH 240
  241 PDFPEKGPEE INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG 300
  301 ETLIQNRMST TLSSLKEKVS AARCPLPLFT CLHVKPDVSE LMFADWVEFS PYEIGMAKYG 360
  361 TFMTPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL FNRVLGVSGS QNKGSTMEEE 420
  421 LENITAKHIV SNDSSDSDDE AQGPKGTENE DAEREYQNDN QASWVHRMLM ALVSDSALFN 480
  481 TREGRAGKEH NFMLGLNLNT SYPLSPLRDF SPQDSFDDDE LDAAVADPDE FERIYEPLDV 540
  541 KSKKIHVVDS GLTFNLPYPL ILRPQRGVDL IISFDFSARP SDTSPPFKEL LLAEKWAKMN 600
  601 KLPFPKIDPY VFDREGLKEC YVFKPKNPDV EKDCPTIIHF VLANINFRKY KAPGVLRETK 660
  661 EEKEIADFDI FDDPESPFST FNFQYPNQAF KRLHDLMYFN TLNNIDVIKD AIVESIEYRR 720
  721 QNPSRCSVSL SNVEARKFFN KEFLSKPTAE SI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle