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Protein Overview: AAPK2_RAT

General Information:
Name(s) found: AAPK2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|728758|sp|Q09137.1|AAPK2_RAT RecName: Full=5'-AMP-activated protein kinase catalytic subunit alpha-2; Short=AMPK alpha-2 chain [NCBI NR]
  • gi|488376|emb|CAA82620.1| AMP-activated protein kinase [Rattus norvegicus] [NCBI NR]
  • gi|13027454|ref|NP_076481.1| AMP-activated protein kinase alpha 2 catalytic subunit [Rattus norvegicus] [NCBI NR]
  • pir||A53621 [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase (EC 2.7.1.109) - rat [NCBI NR]
  • 5'-AMP-activated protein kinase catalytic subunit alpha-2 OS=Rattus norvegicus GN=Prkaa2 PE=1 SV=1 [Swiss-Prot]
  • (Q09137) 5'-AMP-activated protein kinase, catalytic alpha-2 chain (EC 2.7.1.-) (AMPK alpha-2 chain) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):5-143488593;5-143488593 Splice isoform Long of Q09137 [hmr_yeast5_DM3-1_pombe.fasta]
  • AMP-activated protein kinase alpha 2 catalytic subunit; AMP-activated protein kinase [HMR_022704-rand.fasta]
  • AMP-activated protein kinase alpha 2 catalytic subunit [Rattus norvegicus]gi|488376|emb|CAA82620.1| AMP-activated protein kinase [Rattus norvegicus]gi|728758|sp|Q09137|AAK2_RAT 5'-AMP-activated protein kinase, catalytic alpha-2 chain (AMPK alpha-2 chain [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform Long of 5'-AMP-activated protein kinase catalytic subunit alpha-2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Splice Isoform Long of 5'-AMP-activated protein kinase, catalytic alpha-2 chain [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • (NM_023991) AMP-activated protein kinase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • AMP-activated protein kinase alpha 2 catalytic subunit [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • AMP-activated protein kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SPLICE ISOFORM 1 OF 5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Prkaa2 Isoform Long of 5'-AMP-activated protein kinase catalytic subunit alpha-2 [rat-ipi-250309-contam.fasta]
  • 5'-AMP-activated protein kinase catalytic subunit alpha-2 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Isoform Long of 5'-AMP-activated protein kinase catalytic subunit alpha-2 OS=Rattus norvegicus GN=Prkaa2 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 552 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][TAS]
    cytosol [UNKNOWN]
    protein complex [IDA]
    nucleoplasm [UNKNOWN]
    AMP-activated protein kinase complex [IDA][IMP]
    Biological Process: regulation of fatty acid oxidation [UNKNOWN]
    cholesterol biosynthetic process [IEA]
    response to caffeine [IDA]
    protein heterooligomerization [IDA]
    response to activity [IDA]
    protein amino acid phosphorylation [IDA]
    fatty acid biosynthetic process [IEA]
    regulation of lipid metabolic process [IDA]
    cellular response to organic nitrogen [IEP]
    response to stress [IDA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IDA]
    AMP-activated protein kinase activity [IDA][IMP]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [IDA]
    transferase activity [IEA]
    protein binding, bridging [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ KIRSLDVVGK  60
   61 IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE LFDYICKHGR VEEVEARRLF 120
  121 QQILSAVDYC HRHMVVHRDL KPENVLLDAQ MNAKIADFGL SNMMSDGEFL RTSCGSPNYA 180
  181 APEVISGRLY AGPEVDIWSC GVILYALLCG TLPFDDEHVP TLFKKIRGGV FYIPEYLNRS 240
  241 IATLLMHMLQ VDPLKRATIK DIREHEWFKQ DLPSYLFPED PSYDANVIDD EAVKEVCEKF 300
  301 ECTESEVMNS LYSGDPQDQL AVAYHLIIDN RRIMNQASEF YLASSPPTGS FMDDMAMHIP 360
  361 PGLKPHPERM PPLIADSPKA RCPLDALNTT KPKSLAVKKA KWHLGIRSQS KPYDIMAEVY 420
  421 RAMKQLDFEW KVVNAYHLRV RRKNPVTGNY VKMSLQLYLV DNRSYLLDFK SIDDEVVEQR 480
  481 SGSSTPQRSC SAAGLHRPRS SVDSSTAENH SLSGSLTGSL TGSTLSSASP RLGSHTMDFF 540
  541 EMCASLITAL AR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle