Protein Overview: ANPRC_RAT

General Information:
Name(s) found:	ANPRC_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981282\|ref\|NP_037000.1\| natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) [Rattus norvegicus] [NCBI NR] gi\|439456\|gb\|AAA41721.1\| amino acid feature: cytoplasmic domain, bp 1509 .. 1622; amino acid feature: extracellular domain, bp 138 .. 1442; amino acid feature: transmembrane domain, bp 1443 .. 1508 [NCBI NR] gi\|149027306\|gb\|EDL82973.1\| natriuretic peptide receptor 3, isoform CRA_c [Rattus norvegicus] [NCBI NR] gi\|1168459\|sp\|P41740.1\|ANPRC_RAT RecName: Full=Atrial natriuretic peptide clearance receptor; AltName: Full=Atrial natriuretic peptide C-type receptor; Short=ANPRC; Short=ANP-C; Short=NPR-C; Flags: Precursor [NCBI NR] pir\|\|A54155 natriuretic peptide receptor C precursor - rat [NCBI NR] Atrial natriuretic peptide receptor 3 OS=Rattus norvegicus GN=Npr3 PE=2 SV=1 [Swiss-Prot] (P41740) Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) [Swiss-Prot] Ensembl_locations(Chr-bp):2-54947287 Atrial natriuretic peptide clearance receptor precursor [hmr_yeast5_DM3-1_pombe.fasta] natriuretic peptide receptor 3; Atrial natriuretic peptide clearence receptor 3 [HMR_022704-rand.fasta] natriuretic peptide receptor 3 [Rattus norvegicus]gi\|1083728\|pir\|\|A54155 natriuretic peptide receptor C precursor - ratgi\|439456\|gb\|AAA41721.1\| amino acid feature: cytoplasmic domain, bp 1509 .. 1622; amino acid feature: extracellular domain, bp 138 .. [nrdb_11152004_Chlamydomonas] (NM_012868) natriuretic peptide receptor 3; Atrial natriuretic peptide clearence receptor 3 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Atrial natriuretic peptide clearance receptor precursor (Atrial natriuretic peptide C-type receptor) (ANPRC) (ANP-C) (NPR-C) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] natriuretic peptide receptor 3 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] natriuretic peptide receptor 3, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] amino acid feature: cytoplasmic domain, bp 1509 .. 1622; amino acid feature: extracellular domain, bp 138 .. 1442; amino acid feature: transmembrane domain, bp 1443 .. 1508 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) [nr-271106-contam.fasta] atrial natriuretic peptide receptor 3 precursor [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Atrial natriuretic peptide receptor 3 OS=Rattus norvegicus GN=Npr3 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	535 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] membrane [IEA] integral to membrane [IEA]
Biological Process:	osteoclast proliferation [ISS] inhibition of adenylate cyclase activity by G-protein signaling pathway [IMP] negative regulation of adenylate cyclase activity [IDA] skeletal system development [ISS] phosphoinositide-mediated signaling [IMP] activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger [IMP] regulation of blood pressure [IMP][ISS] diuresis [ISS] pancreatic juice secretion [IMP] regulation of osteoblast proliferation [ISS]
Molecular Function:	peptide receptor activity, G-protein coupled [IEA] protein homodimerization activity [IDA] hormone binding [UNKNOWN] peptide hormone binding [IDA] receptor activity [IEA] natriuretic peptide receptor activity [UNKNOWN][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSLLLFTFS ACVLLARALL AGGASSGGGD TGPGNRRRER EALAAQKIEV LVLLPRDDSY  60
   61 LFSLARVRPA IEYALRSVEG NGTGRKLLPP GTRFQVAYED SDCGNRALFS LVDRVAAARG 120
  121 AKPDLILGPV CEYAAAPVAR LASHWDLPML SAGALAAGFQ HKDTEYSHLT RVAPAYAKMG 180
  181 EMMLALFRHH HWSRAALLYS DDKLERNCYF TLEGVHEVFQ EEGLHTSAYN FDETKDLDLD 240
  241 DIVRYIQGSE RVVIMCASGD TIRRIMLAVH RHGMTSGDYA FFNIELFNSS SYGDGSWKRG 300
  301 DKHDFEAKQA YSSLQTVTLL RTAKPEFEKF SMEVKSSVEK QGLNEEDYVN MFVEGFHDAI 360
  361 LLYVLALHEV LRAGYSKKDG GKIIQQTWNR TFEGIAGQVS IDANGDRYGD FSVVAMTDTE 420
  421 AGTQEVIGDY FGKEGRFKMR SNVKYPWGSL KLRIDETRIV EHTNSSPCKS CGLEESAVTG 480
  481 IVVGALLGAG LLMAFYFFRK KYRITIERRN HQEESNIGKH RELREDSIRS HFSVA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ANPRC_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: