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Protein Overview: FGF1_RAT

General Information:
Name(s) found: FGF1_RAT [Swiss-Prot]
Description(s) found:
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  • pir||S04147 acidic fibroblast growth factor 1 - rat [NCBI NR]
  • gi|6978839|ref|NP_036978.1| fibroblast growth factor 1 [Rattus norvegicus] [NCBI NR]
  • gi|56352|emb|CAA32448.1| unnamed protein product [Rattus norvegicus] [NCBI NR]
  • gi|47117672|sp|P61149.1|FGF1_RAT RecName: Full=Heparin-binding growth factor 1; Short=HBGF-1; AltName: Full=Acidic fibroblast growth factor; Short=aFGF; Flags: Precursor [NCBI NR]
  • gi|149017409|gb|EDL76460.1| fibroblast growth factor 1, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149017408|gb|EDL76459.1| fibroblast growth factor 1, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149017407|gb|EDL76458.1| fibroblast growth factor 1, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149017406|gb|EDL76457.1| fibroblast growth factor 1, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149017405|gb|EDL76456.1| fibroblast growth factor 1, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • Fibroblast growth factor 1 OS=Rattus norvegicus GN=Fgf1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):18-52677106 Heparin-binding growth factor 1 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • fibroblast growth factor 1; Fibroblast growth factor 1 (heparin binding) [HMR_022704-rand.fasta]
  • Fgf1 protein [Mus musculus]gi|6978839|ref|NP_036978.1| fibroblast growth factor 1 [Rattus norvegicus]gi|6753850|ref|NP_034327.1| fibroblast growth factor 1 [Mus musculus]gi|56352|emb|CAA32448.1| unnamed protein product [Rattus norvegicus]gi|1469375|gb [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Heparin-binding growth factor 1 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_012846) fibroblast growth factor 1; Fibroblast growth factor 1 (heparin binding) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Heparin-binding growth factor 1 precursor (HBGF-1) (Acidic fibroblast growth factor) (aFGF) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • fibroblast growth factor 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • fibroblast growth factor 1, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Fgf1 Heparin-binding growth factor 1 [rat-ipi-250309-contam.fasta]
  • Heparin-binding growth factor 1 OS=Rattus norvegicus GN=Fgf1 [011711_HMR.fasta]
  • Heparin-binding growth factor 1 OS=Rattus norvegicus GN=Fgf1 PE=1 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 155 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    extracellular space [UNKNOWN][IEA]
    cytoplasm [IDA]
    cytosol [UNKNOWN][ISS]
    extracellular region [UNKNOWN][ISS]
    nucleolus [IDA]
    proteinaceous extracellular matrix [UNKNOWN][IEA]
    Biological Process: multicellular organismal development [IEA]
    positive regulation of cell proliferation [UNKNOWN]
    nervous system development [IDA]
    fibroblast growth factor receptor signaling pathway [UNKNOWN][IEA]
    intracellular protein kinase cascade [IDA]
    positive regulation of cell adhesion [IDA]
    cellular response to heat [UNKNOWN][ISS]
    positive regulation of cell division [IEA]
    angiogenesis [IEA]
    positive regulation of protein amino acid phosphorylation [UNKNOWN][IEA]
    induction of an organ [UNKNOWN][IEA]
    cell differentiation [IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    positive regulation of epithelial cell proliferation [UNKNOWN][IEA]
    lung development [UNKNOWN][IEA]
    Molecular Function: S100 alpha binding [UNKNOWN]
    growth factor activity [IDA]
    protein binding [UNKNOWN][IEA]
    heparin binding [IEA]
    fibroblast growth factor receptor binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ  60
   61 LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF LERLEENHYN TYTSKKHAEK 120
  121 NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 57.30103 NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fibroblast growth factor receptor binding
    		•  5.68976822724664 bayes_pls_golite062009
  • growth factor activity
    		•  5.6790632853895 bayes_pls_golite062009
  • receptor binding
    		•  4.8109037277027 bayes_pls_golite062009
  • cytokine activity
    		•  3.72907359340826 bayes_pls_golite062009
  • protein binding
    		•  2.99442649109752 bayes_pls_golite062009
  • binding
    		•  2.90110516688922 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49177421879896 bayes_pls_golite062009
  • heparin binding
    		•  2.1616134585534 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.81686028727894 bayes_pls_golite062009
  • interleukin-1 receptor binding
    		•  0.8084616632765 bayes_pls_golite062009
  • pattern binding
    		•  0.323275442862789 bayes_pls_golite062009
  • nerve growth factor receptor binding
    		•  0.308245352535379 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle