Protein Overview: GRIK2_RAT

General Information:
Name(s) found:	GRIK2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|3287965\|sp\|P42260.2\|GRIK2_RAT RecName: Full=Glutamate receptor, ionotropic kainate 2; AltName: Full=Glutamate receptor 6; Short=GluR-6; Short=GluR6; Flags: Precursor [NCBI NR] gi\|149046911\|gb\|EDL99659.1\| rCG58533, isoform CRA_b [Rattus norvegicus] [NCBI NR] Glutamate receptor ionotropic, kainate 2 OS=Rattus norvegicus GN=Grik2 PE=1 SV=2 [Swiss-Prot] (P42260) Glutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor 6) (GluR-6) (GluR6) [Swiss-Prot] Ensembl_locations(Chr-bp):20-52680290 Glutamate receptor, ionotropic kainate 2 precursor [hmr_yeast5_DM3-1_pombe.fasta] Glutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor 6) (GluR-6) (GluR6) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Glutamate receptor, ionotropic kainate 2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] rCG58533, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Grik2 Glutamate receptor, ionotropic kainate 2 [rat-ipi-250309-contam.fasta] Glutamate receptor, ionotropic kainate 2 OS=Rattus norvegicus GN=Grik2 [011711_HMR.fasta] Glutamate receptor, ionotropic kainate 2 OS=Rattus norvegicus GN=Grik2 PE=1 SV=2 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	908 amino acids
Gene Ontology:
Cellular Component:	presynaptic membrane [UNKNOWN][IEA] neuronal cell body [UNKNOWN] synapse [IDA] ionotropic glutamate receptor complex [IDA] perikaryon [IDA] plasma membrane [UNKNOWN][IMP] membrane fraction [UNKNOWN][IEA] integral to plasma membrane [IDA] dendrite [IDA] terminal button [IDA] postsynaptic membrane [UNKNOWN][IEA] membrane [UNKNOWN][IEA] dendrite cytoplasm [IDA] cell junction [IEA] kainate selective glutamate receptor complex [UNKNOWN][IEA] axon [IDA]
Biological Process:	regulation of excitatory postsynaptic membrane potential [UNKNOWN][IEA] positive regulation of synaptic transmission [UNKNOWN][IEA] synaptic transmission [UNKNOWN][IMP] receptor clustering [IDA] intracellular protein transport [UNKNOWN][IEA] behavioral fear response [UNKNOWN][IEA] cellular calcium ion homeostasis [UNKNOWN][IEA] negative regulation of neuron apoptosis [UNKNOWN][IEA] regulation of JNK cascade [IMP] ion transport [IEA] regulation of membrane potential [UNKNOWN][IEA] regulation of long-term neuronal synaptic plasticity [UNKNOWN][IEA] regulation of inhibitory postsynaptic membrane potential [UNKNOWN][IEA] regulation of synaptic transmission [UNKNOWN] negative regulation of synaptic transmission, glutamatergic [UNKNOWN][IDA] regulation of short-term neuronal synaptic plasticity [UNKNOWN][IEA] neuron apoptosis [UNKNOWN][IMP] regulation of action potential in neuron [UNKNOWN][IEA] synaptic transmission, glutamatergic [UNKNOWN]
Molecular Function:	ion channel activity [IEA] ubiquitin conjugating enzyme binding [IPI] identical protein binding [IDA] protein binding [IPI] kainate selective glutamate receptor activity [UNKNOWN][IDA] ubiquitin protein ligase binding [IPI] protein homodimerization activity [IDA] glutamate receptor activity [IDA] PDZ domain binding [IPI] receptor activity [IEA] ionotropic glutamate receptor activity [IEA][TAS] extracellular-glutamate-gated ion channel activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIISPVLSN LVFSRSIKVL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA  60
   61 VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 120
  121 ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 180
  181 GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 240
  241 QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 300
  301 LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 360
  361 SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 420
  421 PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 480
  481 RLVEDGKYGA QDDVNGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 540
  541 LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD 600
  601 VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 660
  661 VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SRRQSVLVKS 720
  721 NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 780
  781 AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 840
  841 EFLYKSKKNA QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR 900
  901 LPGKETMA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: GRIK2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: