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Protein Overview: IDHC_RAT

General Information:
Name(s) found: IDHC_RAT [Swiss-Prot]
Description(s) found:
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  • pir||A54756 isocitrate dehydrogenase (NADP) (EC 1.1.1.42), cytosolic - rat [NCBI NR]
  • gi|537941|gb|AAA59356.1| cytosolic NADP-dependent isocitrate dehydrogenase [NCBI NR]
  • gi|149045972|gb|EDL98865.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149045971|gb|EDL98864.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149045970|gb|EDL98863.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149045968|gb|EDL98861.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|13928690|ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus] [NCBI NR]
  • gi|1170478|sp|P41562.1|IDHC_RAT RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic; Short=IDH; AltName: Full=Cytosolic NADP-isocitrate dehydrogenase; AltName: Full=Oxalosuccinate decarboxylase; AltName: Full=NADP(+)-specific ICDH; AltName: Full=IDP [NCBI NR]
  • Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):9-69612231 Isocitrate dehydrogenase [NADP] cytoplasmic [hmr_yeast5_DM3-1_pombe.fasta]
  • isocitrate dehydrogenase 1; Isocitrate dehydrogenase 1, soluble; Isocitrate dehydrogenase 1 soluble [HMR_022704-rand.fasta]
  • isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]gi|1170478|sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)gi|627999|pir||A54756 isocitrate dehydrogenase (NADP [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Isocitrate dehydrogenase [NADP] cytoplasmic [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_031510) isocitrate dehydrogenase 1, soluble [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (NADP(+)-specific ICDH) (IDP) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • cytosolic NADP-dependent isocitrate dehydrogenase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Idh1 Isocitrate dehydrogenase [NADP] cytoplasmic [rat-ipi-250309-contam.fasta]
  • Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 414 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDA]
    cytoplasm [UNKNOWN]
    mitochondrion [UNKNOWN]
    cytosol [UNKNOWN]
    Biological Process: response to oxidative stress [UNKNOWN]
    glutathione metabolic process [UNKNOWN]
    isocitrate metabolic process [UNKNOWN][IDA][IEA]
    NADPH regeneration [UNKNOWN]
    oxidation reduction [IEA]
    female gonad development [IEP]
    response to organic cyclic substance [IDA]
    response to steroid hormone stimulus [IDA]
    2-oxoglutarate metabolic process [UNKNOWN]
    Molecular Function: magnesium ion binding [UNKNOWN][IEA]
    NADP or NADPH binding [IDA]
    protein homodimerization activity [UNKNOWN]
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [IEA]
    NAD or NADH binding [IEA]
    isocitrate dehydrogenase (NADP+) activity [UNKNOWN][IDA][IEA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKIHGGSV VEMQGDEMTR IIWELIKEKL ILPYVELDLH SYDLGIENRD ATNDQVTKDA  60
   61 AEAIKKYNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL 120
  121 VTGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPKD GSQKVTYLVH DFEEGGGVAM 180
  181 GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSKFE 240
  241 AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLICPDG 300
  301 KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWSRGL AHRAKLDNNT ELSFFANALE 360
  361 EVCIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKAKLA QAKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle