Protein Overview: GRM1_RAT

General Information:
Name(s) found:	GRM1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|8393487\|ref\|NP_058707.1\| glutamate receptor, metabotropic 1 isoform alpha precursor [Rattus norvegicus] [NCBI NR] gi\|56647\|emb\|CAA40799.1\| metabotropic glutamate receptor [Rattus norvegicus] [NCBI NR] pir\|\|A41939 G protein-coupled glutamate receptor - rat [NCBI NR] gi\|227546\|prf\|\|1706352A metabotropic Glu receptor [NCBI NR] gi\|204460\|gb\|AAA19497.1\| metabotropic glutamate receptor [NCBI NR] gi\|121300\|sp\|P23385.1\|GRM1_RAT RecName: Full=Metabotropic glutamate receptor 1; Short=mGluR1; Flags: Precursor [NCBI NR] Metabotropic glutamate receptor 1 precursor (mGluR1) - Rattus norvegicus (Rat) [Swiss-Prot] Metabotropic glutamate receptor 1 OS=Rattus norvegicus GN=Grm1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):1-7040712 Splice isoform 1A of P23385 [hmr_yeast5_DM3-1_pombe.fasta] glutamate receptor, metabotropic 1; G protein coupled receptor family C group 1 member A [HMR_022704-rand.fasta] glutamate receptor, metabotropic 1 [Rattus norvegicus]gi\|56647\|emb\|CAA40799.1\| metabotropic glutamate receptor [Rattus norvegicus]gi\|285288\|pir\|\|A41939 G protein-coupled glutamate receptor - ratgi\|121300\|sp\|P23385\|MGR1_RAT Metabotropic glutamate recept [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 1A of Metabotropic glutamate receptor 1 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_017011) glutamate receptor, metabotropic 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Metabotropic glutamate receptor 1 precursor (mGluR1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] glutamate receptor, metabotropic 1 isoform alpha precursor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] metabotropic Glu receptor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] metabotropic glutamate receptor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] metabotropic glutamate receptor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF METABOTROPIC GLUTAMATE RECEPTOR 1 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] glutamate receptor, metabotropic 1 [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Grm1 Isoform 1A of Metabotropic glutamate receptor 1 [rat-ipi-250309-contam.fasta] Isoform 1A of Metabotropic glutamate receptor 1 OS=Rattus norvegicus GN=Grm1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1199 amino acids
Gene Ontology:
Cellular Component:	presynaptic membrane [IDA] nucleus [UNKNOWN][IEA] integral to plasma membrane [TAS] postsynaptic density [UNKNOWN][IDA] dendritic spine [IDA] microsome [UNKNOWN][IEA] integral to membrane [IEA] plasma membrane [IEA] axon [IDA]
Biological Process:	regulation of glutamate secretion [TAS] regulation of MAPKKK cascade [IEA] G-protein coupled receptor protein signaling pathway [IEA] signal transduction [IEA] synaptic transmission [IEP] activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway [TAS] activation of MAPK activity [IEA] activation of MAPKK activity [IEA] locomotory behavior [IEA] elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger [TAS] sensory perception of pain [IEP] calcium-mediated signaling [IDA] membrane depolarization [TAS] synaptic transmission, GABAergic [TAS] regulation of synaptic transmission, glutamatergic [IDA] regulation of sensory perception of pain [IEA]
Molecular Function:	G-protein coupled receptor activity [IEA][TAS] protein binding [UNKNOWN][IEA] glutamate receptor activity [TAS] PLC activating metabotropic glutamate receptor activity [TAS] receptor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRLLLIFFP MIFLEMSILP RMPDRKVLLA GASSQRSVAR MDGDVIIGAL FSVHHQPPAE  60
   61 KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT LGSEIRDSCW HSSVALEQSI 120
  121 EFIRDSLISI RDEKDGLNRC LPDGQTLPPG RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI 180
  181 PQIAYSATSI DLSDKTLYKY FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG 240
  241 MDAFKELAAQ EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 300
  301 SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF DDYFLKLRLD 360
  361 TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KKVCTGNESL EENYVQDSKM GFVINAIYAM 420
  421 AHGLQNMHHA LCPGHVGLCD AMKPIDGRKL LDFLIKSSFV GVSGEEVWFD EKGDAPGRYD 480
  481 IMNLQYTEAN RYDYVHVGTW HEGVLNIDDY KIQMNKSGMV RSVCSEPCLK GQIKVIRKGE 540
  541 VSCCWICTAC KENEFVQDEF TCRACDLGWW PNAELTGCEP IPVRYLEWSD IESIIAIAFS 600
  601 CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA KPTTTSCYLQ 660
  661 RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF MSAWAQVIIA SILISVQLTL 720
  721 VVTLIIMEPP MPILSYPSIK EVYLICNTSN LGVVAPVGYN GLLIMSCTYY AFKTRNVPAN 780
  781 FNEAKYIAFT MYTTCIIWLA FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA 840
  841 KPERNVRSAF TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK PGAGNANSNG KSVSWSEPGG 900
  901 RQAPKGQHVW QRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDAS TKTLYNVEEE 960
  961 DNTPSAHFSP PSSPSMVVHR RGPPVATTPP LPPHLTAEET PLFLADSVIP KGLPPPLPQQ1020
 1021 QPQQPPPQQP PQQPKSLMDQ LQGVVTNFGS GIPDFHAVLA GPGTPGNSLR SLYPPPPPPQ1080
 1081 HLQMLPLHLS TFQEESISPP GEDIDDDSER FKLLQEFVYE REGNTEEDEL EEEEDLPTAS1140
 1141 KLTPEDSPAL TPPSPFRDSV ASGSSVPSSP VSESVLCTPP NVTYASVILR DYKQSSSTL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: GRM1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: