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Protein Overview: MYH6_RAT

General Information:
Name(s) found: MYH6_RAT [Swiss-Prot]
Description(s) found:
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  • pir||S06005 myosin alpha heavy chain, cardiac muscle [similarity] - rat [NCBI NR]
  • gi|8393804|ref|NP_058935.1| myosin, heavy polypeptide 6, cardiac muscle, alpha [Rattus norvegicus] [NCBI NR]
  • gi|56655|emb|CAA34064.1| unnamed protein product [Rattus norvegicus] [NCBI NR]
  • gi|127741|sp|P02563.2|MYH6_RAT RecName: Full=Myosin-6; AltName: Full=Myosin heavy chain 6; AltName: Full=Myosin heavy chain, cardiac muscle alpha isoform; Short=MyHC-alpha [NCBI NR]
  • Myosin-6 OS=Rattus norvegicus GN=Myh6 PE=1 SV=2 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):15-31966878 Myosin heavy chain, cardiac muscle alpha isoform [hmr_yeast5_DM3-1_pombe.fasta]
  • myosin heavy chain, polypeptide 6; myosin heavy chain, cardiac muscle, adult; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin heavy chain cardiac muscle adult; myosin heavy chain polypeptide 6 cardiac muscle alpha; myosin heavy chain poly [HMR_022704-rand.fasta]
  • myosin heavy chain, polypeptide 6 [Rattus norvegicus]gi|56655|emb|CAA34064.1| unnamed protein product [Rattus norvegicus]gi|127741|sp|P02563|MYH6_RAT Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha)gi|92498|pir||S06005 myosin alpha heavy c [nrdb_11152004_Chlamydomonas]
  • (NM_017239) myosin heavy chain, polypeptide 6; myosin heavy chain, cardiac muscle, adult; myosin heavy chain, polypeptide 6, cardiac muscle, alpha [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Tax_Id=10116 Myosin heavy chain, cardiac muscle alpha isoform [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta]
  • Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 MYOSIN HEAVY CHAIN, CARDIAC MUSCLE ALPHA ISOFORM [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • myosin heavy chain, polypeptide 6 [Rattus norvegicus] [nr-271106-contam.fasta]
  • Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha) [nr-271106-contam.fasta]
  • Myosin-6 OS=Rattus norvegicus GN=Myh6 [011711_HMR.fasta]
  • Myosin-6 OS=Rattus norvegicus GN=Myh6 PE=2 SV=2 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 1938 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    myosin complex [UNKNOWN]
    contractile fiber [IMP]
    perinuclear region of cytoplasm [IMP]
    muscle myosin complex [IDA]
    focal adhesion [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IDA]
    myosin filament [IEA]
    nucleolus [UNKNOWN][IEA]
    myofibril [UNKNOWN][IDA]
    Biological Process: ventricular cardiac muscle tissue morphogenesis [UNKNOWN][IEA]
    ATP catabolic process [IMP]
    regulation of heart contraction [UNKNOWN]
    sarcomere organization [UNKNOWN][IEA]
    striated muscle contraction [UNKNOWN][IEA]
    cardiac muscle fiber development [UNKNOWN][IEA]
    regulation of blood pressure [UNKNOWN][IEA]
    visceral muscle development [UNKNOWN][IEA]
    adult heart development [UNKNOWN][IEA]
    regulation of the force of heart contraction [UNKNOWN][IEA]
    myofibril assembly [UNKNOWN]
    regulation of heart rate [UNKNOWN][IEA]
    in utero embryonic development [UNKNOWN][IEA]
    muscle contraction [UNKNOWN][IMP]
    regulation of ATPase activity [UNKNOWN][IEA]
    actin filament-based movement [UNKNOWN][IEA]
    muscle filament sliding [UNKNOWN][IEA]
    atrial cardiac muscle tissue morphogenesis [UNKNOWN][IEA]
    Molecular Function: nucleotide binding [IEA]
    ATPase activity [UNKNOWN][IEA]
    calcium-dependent ATPase activity [IMP]
    ATP binding [IDA][IMP]
    actin-dependent ATPase activity [UNKNOWN][IEA]
    calmodulin binding [IEA]
    protein binding [UNKNOWN]
    structural constituent of muscle [UNKNOWN][IEA]
    protein homodimerization activity [IDA]
    actin binding [IEA]
    protein heterodimerization activity [IDA]
    microfilament motor activity [UNKNOWN][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDAQMADFG AARYLRKSEK ERLEAQTRPF DIRTECFVPD DKEEYVKAKI VSREGGKVTA  60
   61 ETENGKTVTV KEDQVMQQNP PKFDKIEDMA MLTFLHEPAV LYNLKERYAA WMIYTYSGLF 120
  121 CVTVNPYKWL PVYNAEVVAA YRGKKRSEAP PHIFSISDNA YQYMLTDREN QSILITGESG 180
  181 AGKTVNTKRV IQYFASIAAI GDRSKKDNPN ANKGTLEDQI IQANPALEAF GNAKTVRNDN 240
  241 SSRFGKFIRI HFGATGKLAS ADIETYLLEK SRVIFQLKAE RNYHIFYQIL SNKKPELLDM 300
  301 LLVTNNPYDY AFVSQGEVSV ASIDDSEELL ATDSAFDVLG FTAEEKAGVY KLTGAIMHYG 360
  361 NMKFKQKQRE EQAEPDGTED ADKSAYLMGL NSADLLKGLC HPRVKVGNEY VTKGQSVQQV 420
  421 YYSIGALAKS VYEKMFNWMV TRINATLETK QPRQYFIGVL DIAGFEIFDF NSFEQLCINF 480
  481 TNEKLQQFFN HHMFVLEQEE YKKEGIEWEF IDFGMDLQAC IDLIEKPMGI MSILEEECMF 540
  541 PKATDMTFKA KLYDNHLGKS NNFQKPRNVK GKQEAHFSLV HYAGTVDYNI LGWLEKNKDP 600
  601 LNETVVGLYQ KSSLKLMATL FSTYASADTG DSGKGKGGKK KGSSFQTVSA LHRENLNKLM 660
  661 TNLRTTHPHF VRCIIPNERK APGVMDNPLV MHQLRCNGVL EGIRICRKGF PNRILYGDFR 720
  721 QRYRILNPAA IPEGQFIDSG KGAEKLLGSL DIDHNQYKFG HTKVFFKAGL LGLLEEMRDE 780
  781 RLSRIITRIQ AQARGQLMRI EFKKMVERRD ALLVIQWNIR AFMGVKNWPW MKLYFKIKPL 840
  841 LKSAETEKEM ANMKEEFGRV KDALEKSEAR RKELEEKMVS LLQEKNDLQL QVQAEQDNLA 900
  901 DAEERCDQLI KNKIQLEAKV KEMTERLEDE EEMNAELTAK KRKLEDECSE LKKDIDDLEL 960
  961 TLAKVEKEKH ATENKVKNLT EEMAGLDEII AKLTKEKKAL QEAHQQALDD LQAEEDKVNT1020
 1021 LTKSKVKLEQ QVDDLEGSLE QEKKVRMDLE RAKRKLEGDL KLTQESIMDL ENDKLQLEEK1080
 1081 LKKKEFDISQ QNSKIEDEQA LALQLQKKLK ENQARIEELE EELEAERTAR AKVEKLRSDL1140
 1141 TRELEEISER LEEAGGATSV QIEMNKKREA EFQKMRRDLE EATLQHEATA AALRKKHADS1200
 1201 VAELGEQIDN LQRVKQKLEK EKSEFKLELD DVTSHMEQII KAKANLEKVS RTLEDQANEY1260
 1261 RVKLEEAQRS LNDFTTQRAK LQTENGELAR QLEEKEALIW QLTRGKLSYT QQMEDLKRQL1320
 1321 EEEGKAKNAL AHALQSARHD CDLLREQYEE EMEAKAELQR VLSKANSEVA QWRTKYETDA1380
 1381 IQRTEELEEA KKKLAQRLQD AEEAVEAVNA KCSSLEKTKH RLQNEIEDLM VDVERSNAAA1440
 1441 AALDKKQRNF DKILAEWKQK YEESQSELES SQKEARSLST ELFKLKNAYE ESLEHLETFK1500
 1501 RENKNLQEEI SDLTEQLGEG GKNVHELEKI RKQLEVEKLE LQSALEEAEA SLEHEEGKIL1560
 1561 RAQLEFNQIK AEIERKLAEK DEEMEQAKRN HLRVVDSLQT SLDAETRSRN EALRVKKKME1620
 1621 GDLNEMEIQL SQANRIASEA QKHLKNAQAH LKDTQLQLDD AVRANDDLKE NIAIVERRNT1680
 1681 LLQAELEELR AVVEQTERSR KLAEQELIET SERVQLLHSQ NTSLINQKKK MDADLSQLQT1740
 1741 EVEEAVQECR NAEEKAKKAI TDAAMMAEEL KKEQDTSAHL ERMKKNMEQT IKDLQHRLDE1800
 1801 AEQIALKGGK KQLQKLEARV RELENELEAE QKRNAESVKG MRKSERRIKE LTYQTEEDKK1860
 1861 NLVRLQDLVD KLQLKVKAYK RQAEEAEEQA NTNLSKFRKV QHELDEAEER ADIAESQVNK1920
 1921 LRAKSRDIGA KQKMHDEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle