Protein Overview: PDE4A_RAT

General Information:
Name(s) found:	PDE4A_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|I53865 phosphodiesterase - rat [NCBI NR] gi\|6981346\|ref\|NP_037233.1\| phosphodiesterase 4A [Rattus norvegicus] [NCBI NR] gi\|436004\|gb\|AAC27098.1\| phosphodiesterase [Rattus norvegicus] [NCBI NR] gi\|1705947\|sp\|P54748.1\|PDE4A_RAT RecName: Full=cAMP-specific 3',5'-cyclic phosphodiesterase 4A; AltName: Full=DPDE2 [NCBI NR] gi\|158518444\|ref\|NP_037233.3\| phosphodiesterase 4A [Rattus norvegicus] [NCBI NR] cAMP-specific 3',5'-cyclic phosphodiesterase 4A OS=Rattus norvegicus GN=Pde4a PE=1 SV=1 [Swiss-Prot] (P54748) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) [Swiss-Prot] Ensembl_locations(Chr-bp):5-194135398;5-194135398 Splice isoform 1 of P54748 [hmr_yeast5_DM3-1_pombe.fasta] phosphodiesterase 4A [HMR_022704-rand.fasta] phosphodiesterase 4A [Rattus norvegicus]gi\|7514043\|pir\|\|I53865 phosphodiesterase - ratgi\|436004\|gb\|AAC27098.1\| phosphodiesterase [Rattus norvegicus]gi\|1705947\|sp\|P54748\|CN4A_RAT cAMP-specific 3',5'-cyclic phosphodiesterase 4A (DPDE2) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_013101) phosphodiesterase 4A [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] cAMP-specific 3',5'-cyclic phosphodiesterase 4A (DPDE2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] phosphodiesterase 4A [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] phosphodiesterase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Pde4a Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A [rat-ipi-250309-contam.fasta] cAMP-specific 3',5'-cyclic phosphodiesterase 4A [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A OS=Rattus norvegicus GN=Pde4a [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	844 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] perinuclear region of cytoplasm [UNKNOWN][IDA] cytoplasm [IDA] cytosol [UNKNOWN]
Biological Process:	signal transduction [IEA] response to drug [IEP] cAMP catabolic process [IDA]
Molecular Function:	protein binding [UNKNOWN][IPI] catalytic activity [IEA] metal ion binding [IEA] 3',5'-cyclic-AMP phosphodiesterase activity [UNKNOWN][IDA] 3',5'-cyclic-nucleotide phosphodiesterase activity [IEA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPPAAPSER SLSLSLPGPR EGQATLKPPP QHLWRQPRTP IRIQQRGYPD SAERSETERS  60
   61 PHRPIERADA VDTGDRPGLR TTRMSWPSSF HGTGTGGGSS RRLEAENGPT PSPGRSPLDS 120
  121 QASPGLVLHA GATTSQRRES FLYRSDSDYD MSPKAVSRSS SVASEAHAED LIVTPFAQVL 180
  181 ASLRSVRSNF SLLTNVPIPS NKRSPLGGPP SVCKATLSEE TCQQLARETL EELDWCLEQL 240
  241 ETMQTYRSVS EMASHKFKRM LNRELTHLSE MSRSGNQVSE YISNTFLDKQ NEVEIPSPTP 300
  301 RQRAFQQPPP SVLRQSQPMS QITGLKKLVH TGSLNTNVPR FGVKTDQEDL LAQELENLSK 360
  361 WGLNIFCVSE YAGGRSLSCI MYTIFQERDL LKKFHIPVDT MMMYMLTLED HYHADVAYHN 420
  421 SLHAADVLQS THVLLATPAL DAVFTDLEIL AALFAAAIHD VDHPGVSNQF LINTNSELAL 480
  481 MYNDESVLEN HHLAVGFKLL QEENCDIFQN LSKRQRQSLR KMVIDMVLAT DMSKHMTLLA 540
  541 DLKTMVETKK VTSSGVLLLD NYSDRIQVLR NMVHCADLSN PTKPLELYRQ WTDRIMAEFF 600
  601 QQGDRERERG MEISPMCDKH TASVEKSQVG FIDYIVHPLW ETWADLVHPD AQDILDTLED 660
  661 NRDWYHSAIR QSPSPPLEEE PGGLGHPSLP DKFQFELTLE EEEEEDSLEV PGLPTTEETF 720
  721 LAAEDARAQA VDWSKVKGPS TTVVEVAERL KQETASAYGA PQESMEAVGC SFSPGTPILP 780
  781 DVRTLSSSEE APGLLGLPST AAEVEAPRDH LAATRACSAC SGTSGDNSAI ISAPGRWGSG 840
  841 GDPA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Protein Overview: PDE4A_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: