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Protein Overview: IL12A_MOUSE

General Information:
Name(s) found: IL12A_MOUSE [Swiss-Prot]
Description(s) found:
Found 37 descriptions.
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  • Interleukin-12 subunit alpha OS=Mus musculus GN=Il12a PE=2 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IDA]
    extracellular region [IEA]
    interleukin-12 complex [IDA][IGI]
    Biological Process: immune response [IEA]
    positive regulation of interferon-gamma production [IGI]
    positive regulation of T cell proliferation [IDA]
    defense response to protozoan [IGI]
    Molecular Function: growth factor activity [IEA]
    interleukin-12 beta subunit binding [IPI]
    interleukin-12 receptor binding [IEA]
    cytokine activity [UNKNOWN][IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCQSRYLLFL ATLALLNHLS LARVIPVSGP ARCLSQSRNL LKTTDDMVKT AREKLKHYSC  60
   61 TAEDIDHEDI TRDQTSTLKT CLPLELHKNE SCLATRETSS TTRGSCLPPQ KTSLMMTLCL 120
  121 GSIYEDLKMY QTEFQAINAA LQNHNHQQII LDKGMLVAID ELMQSLNHNG ETLRQKPPVG 180
  181 EADPYRVKMK LCILLHAFST RVVTINRVMG YLSSA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 92.69897 Heterodimeric interleukin-12 alpha chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • interleukin-12 binding
    		•  6.97623072079116 bayes_pls_golite062009
  • cytokine receptor binding
    		•  6.47223189691244 bayes_pls_golite062009
  • interleukin-27 binding
    		•  6.42738636095917 bayes_pls_golite062009
  • interleukin-12 beta subunit binding
    		•  5.72528664872472 bayes_pls_golite062009
  • receptor binding
    		•  5.3304255990112 bayes_pls_golite062009
  • cytokine activity
    		•  5.22856893358132 bayes_pls_golite062009
  • growth factor activity
    		•  4.92105782010612 bayes_pls_golite062009
  • interleukin-12 receptor binding
    		•  4.74969286958651 bayes_pls_golite062009
  • protein binding
    		•  3.26483713001551 bayes_pls_golite062009
  • binding
    		•  2.48265117231403 bayes_pls_golite062009
  • prolactin receptor binding
    		•  2.45721634350294 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  2.37535614986843 bayes_pls_golite062009
  • hormone activity
    		•  2.25587306265428 bayes_pls_golite062009
  • growth hormone activity
    		•  1.87531277315347 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  1.79326213321183 bayes_pls_golite062009
  • interleukin-2 receptor binding
    		•  1.24568403220915 bayes_pls_golite062009
  • interleukin-10 receptor binding
    		•  1.21666375770079 bayes_pls_golite062009
  • macrophage colony stimulating factor receptor binding
    		•  1.01092937856314 bayes_pls_golite062009
  • interferon-alpha/beta receptor binding
    		•  0.93290045827216 bayes_pls_golite062009
  • erythropoietin receptor binding
    		•  0.77580300541347 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.486790888007408 bayes_pls_golite062009
  • catalytic activity
    		•  0.246169290135575 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle