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Protein Overview: LEP_MOUSE

General Information:
Name(s) found: LEP_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|74216350|dbj|BAE25117.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|730219|sp|P41160.1|LEP_MOUSE RecName: Full=Leptin; AltName: Full=Obesity factor; Flags: Precursor [NCBI NR]
  • gi|726297|gb|AAA64213.1| obesity protein [NCBI NR]
  • gi|6678678|ref|NP_032519.1| leptin [Mus musculus] [NCBI NR]
  • gi|603288|gb|AAA64564.1| ob [NCBI NR]
  • gi|26326917|dbj|BAC27202.1| unnamed protein product [Mus musculus] [NCBI NR]
  • pir||LTMS leptin precursor - mouse [NCBI NR]
  • gi|210148515|gb|ACJ09173.1| leptin [Mus musculus] [NCBI NR]
  • gi|148681848|gb|EDL13795.1| leptin, isoform CRA_a [Mus musculus] [NCBI NR]
  • gi|148681847|gb|EDL13794.1| leptin, isoform CRA_a [Mus musculus] [NCBI NR]
  • gi|115545388|gb|AAI25246.1| Leptin [Mus musculus] [NCBI NR]
  • gi|1092655|prf||2024338A obeser gene [NCBI NR]
  • (P41160) Leptin precursor (Obesity factor) [Swiss-Prot]
  • Leptin OS=Mus musculus GN=Lep PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):6-28988363 Leptin precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • leptin [HMR_022704-rand.fasta]
  • Leptin precursor [ipi.MOUSE.v3.06.fasta]
  • leptin [Mus musculus]gi|2144651|pir||LTMS leptin precursor - mousegi|603288|gb|AAA64564.1| obgi|726297|gb|AAA64213.1| obesity proteingi|26326917|dbj|BAC27202.1| unnamed protein product [Mus musculus]gi|730219|sp|P41160|OB_MOUSE Leptin precursor (Obes [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Leptin precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_008493) leptin [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • leptin [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Leptin precursor (Obesity factor) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • leptin, isoform CRA_a [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Leptin [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • obeser gene [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ob [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • obesity protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 LEPTIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Lep Leptin [mouse-ipi-250309-contam.fasta]
  • leptin precursor [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Lep Leptin precursor [ipi.MOUSE_jw_12may08.contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Lep Leptin precursor ENSMUSG00000059201 IPI00111526 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • IPI:IPI00111526.1|SWISS-PROT:P41160|TREMBL:Q544U0|ENSEMBL:ENSMUSP00000067046|REFSEQ:NP_032519 Tax_Id=10090 Gene_Symbol=Lep Leptin [ipi.MOUSE.fasta.20090209]
  • Leptin OS=Mus musculus GN=Lep [011711_HMR.fasta]
  • Leptin OS=Mus musculus GN=Lep PE=2 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta]
  • sp|P41160|LEP_MOUSE Leptin OS=Mus musculus GN=Lep PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • tr|Q544U0|Q544U0_MOUSE Leptin OS=Mus musculus GN=Lep PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • Isoform of P41160, Leptin OS=Mus musculus GN=Lep PE=2 SV=1 [MOUSE.fasta.20160308]
    • Organism: Mus musculus
    Length: 167 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IDA]
    extracellular region [IEA]
    Biological Process: insulin secretion [IGI]
    negative regulation of metabolic process [UNKNOWN]
    negative regulation of appetite [IDA]
    cholesterol metabolic process [IGI]
    response to dietary excess [IGI][IMP]
    adult feeding behavior [IDA]
    central nervous system neuron development [IMP]
    glucose metabolic process [IMP]
    bile acid metabolic process [IDA]
    eating behavior [IGI]
    ovulation from ovarian follicle [UNKNOWN]
    regulation of insulin secretion [IMP]
    response to insulin stimulus [IMP]
    regulation of metabolic process [IMP]
    regulation of steroid biosynthetic process [IMP]
    regulation of intestinal cholesterol absorption [IDA]
    fatty acid catabolic process [UNKNOWN]
    positive regulation of myeloid cell differentiation [IDA]
    leptin-mediated signaling pathway [UNKNOWN]
    signal transduction [IEA]
    energy reserve metabolic process [UNKNOWN]
    regulation of gluconeogenesis [IMP]
    positive regulation of MAPKKK cascade [UNKNOWN]
    hormone metabolic process [IMP]
    intracellular signaling pathway [UNKNOWN]
    lipid metabolic process [IMP]
    Molecular Function: growth factor activity [IDA]
    protein binding [IPI]
    peptide hormone receptor binding [UNKNOWN]
    hormone activity [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCWRPLCRFL WLWSYLSYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL  60
   61 DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP 120
  121 QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] PSI-BLAST 73.69897 HUMAN OBESITY PROTEIN, LEPTIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine receptor binding
    		•  6.47223189691244 bayes_pls_golite062009
  • receptor binding
    		•  5.3304255990112 bayes_pls_golite062009
  • cytokine activity
    		•  5.1883241815362 bayes_pls_golite062009
  • growth factor activity
    		•  3.72884804690203 bayes_pls_golite062009
  • protein binding
    		•  3.26483713001551 bayes_pls_golite062009
  • hormone activity
    		•  2.52921243340076 bayes_pls_golite062009
  • binding
    		•  2.48265117231403 bayes_pls_golite062009
  • prolactin receptor binding
    		•  2.45721634350294 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  1.35761970306312 bayes_pls_golite062009
  • growth hormone activity
    		•  0.858583061924711 bayes_pls_golite062009
  • interleukin-27 binding
    		•  0.814859517857 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  0.749565138698391 bayes_pls_golite062009
  • catalytic activity
    		•  0.246169290135575 bayes_pls_golite062009
  • macrophage colony stimulating factor receptor binding
    		•  0.227887473647222 bayes_pls_golite062009
  • interleukin-12 binding
    		•  0.17299185486948 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle