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View Structure Prediction Details

Protein: LEP_MOUSE
Organism: Mus musculus
Length: 167 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEP_MOUSE.

Description E-value Query
Range
Subject
Range
LEP_URSTH - Leptin OS=Ursus thibetanus GN=LEP PE=2 SV=1
gi|90990839 - gi|90990839|dbj|BAE92862.1| leptin [Ursus thibetanus japonicus]
321.0 [0..1] [167..1]
gi|56001057 - gi|56001057|emb|CAI23842.1| leptin precursor [Sus scrofa domestica]
LEP_PIG - Leptin OS=Sus scrofa GN=LEP PE=2 SV=1
gi|55741433 - ref|NP_999005.1| leptin [Sus scrofa]
321.0 [0..1] [167..1]
LEP_FELCA - Leptin OS=Felis catus GN=LEP PE=2 SV=1
320.0 [0..1] [167..1]
gi|208968561 - gi|208968561|dbj|BAG74119.1| leptin [synthetic construct]
LEP - leptin
319.0 [0..1] [167..1]
gi|114615809 - gi|114615809|ref|XP_519353.2| PREDICTED: leptin [Pan troglodytes]
sp|P41159-1|LEP_... - Leptin OS=Homo sapiens GN=LEP PE=1 SV=1 VAR_004197, Leptin OS=Homo sapiens GN=LEP PE=1 SV=1 VAR_0041...
318.0 [0..1] [167..1]
LEP_CANLF - Leptin OS=Canis lupus familiaris GN=LEP PE=2 SV=2
315.0 [0..1] [167..1]

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Predicted Domain #1
Region A:
Residues: [1-167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCWRPLCRFL WLWSYLSYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL  60
   61 DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP 120
  121 QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.69897
Match: 1ax8A
Description: HUMAN OBESITY PROTEIN, LEPTIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.1883241815362 bayes_pls_golite062009
growth factor activity 3.72884804690203 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
hormone activity 2.52921243340076 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 1.35761970306312 bayes_pls_golite062009
growth hormone activity 0.858583061924711 bayes_pls_golite062009
interleukin-27 binding 0.814859517857 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 0.749565138698391 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
macrophage colony stimulating factor receptor binding 0.227887473647222 bayes_pls_golite062009
interleukin-12 binding 0.17299185486948 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle