Protein Overview: S122_MOUSE, S12A...

General Information:
Name(s) found:	S12A2_MOUSE [Swiss-Prot] S122_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6677991\|ref\|NP_033220.1\| solute carrier family 12, member 2 [Mus musculus] [NCBI NR] pir\|\|A55015 bumetanide-sensitive Na(+)-K(+)-2C1- cotransporter protein - mouse [NCBI NR] gi\|560008\|gb\|AAC77832.1\| putative basolateral Na-K-2Cl cotransporter [Mus musculus] [NCBI NR] gi\|1709293\|sp\|P55012.1\|S12A2_MOUSE RecName: Full=Solute carrier family 12 member 2; AltName: Full=Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; AltName: Full=Basolateral Na-K-Cl symporter [NCBI NR] Solute carrier family 12 member 2 OS=Mus musculus GN=Slc12a2 PE=1 SV=1 [Swiss-Prot] (P55012) Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter) [Swiss-Prot] Ensembl_locations(Chr-bp):18-58255426 Solute carrier family 12 member 2 [hmr_yeast5_DM3-1_pombe.fasta] solute carrier family 12, member 2; sodium/potassium/chloride transporters [HMR_022704-rand.fasta] Solute carrier family 12, member 2 [ipi.MOUSE.v3.06.fasta] solute carrier family 12, member 2 [Mus musculus]gi\|560008\|gb\|AAC77832.1\| putative basolateral Na-K-2Cl cotransporter [Mus musculus]gi\|627846\|pir\|\|A55015 bumetanide-sensitive Na(+)-K(+)-2C1- cotransporter protein - mousegi\|1709293\|sp\|P55012\|S122_MOUSE [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Solute carrier family 12 member 2 [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_009194) solute carrier family 12, member 2; sodium/potassium/chloride transporters [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] solute carrier family 12, member 2 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Tax_Id=10090 Solute carrier family 12, member 2 [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta] Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] putative basolateral Na-K-2Cl cotransporter [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 SOLUTE CARRIER FAMILY 12 MEMBER 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Solute carrier family 12 member 2 OS=Mus musculus GN=Slc12a2 [011711_HMR.fasta]
Organism:	Mus musculus
Length:	1205 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [UNKNOWN] membrane [IEA] integral to membrane [IEA] basolateral plasma membrane [IDA] apical plasma membrane [UNKNOWN][IDA]
Biological Process:	potassium ion transport [UNKNOWN] sodium ion transport [UNKNOWN] ion transport [IEA] transmembrane transport [IEA] positive regulation of cell volume [UNKNOWN] detection of mechanical stimulus involved in sensory perception of sound [IMP] transport [IEA] chloride transport [UNKNOWN] hyperosmotic response [UNKNOWN]
Molecular Function:	cation:chloride symporter activity [IEA] protein binding [IPI] sodium:potassium:chloride symporter activity [UNKNOWN] symporter activity [IEA] transporter activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPGPAGPRL APAARPGWGR AAGCRRRGGP ARHGRASGQE DATTAGRQAG GGVRGEGTPA  60
   61 AGDGLGRPLG PTPSQSRFQV DPVSENAGRA AAAAAAAAAA AAAAGAAGKE TPAAGKAGGE 120
  121 SGVAKGSEEA KGRFRVNFVD PAASSSADDS LSDAAGVGGD GPNVSFQNGG DTVLSEGSSL 180
  181 HSGGGSGHHQ QYYYDTHTNT YYLRTFGHNT MDAVPRIDHY RHTAAQLGEK LLRPSLAELH 240
  241 DELEKEPFED GFANGEESTP TRDAVVAYTA ESKGVVKFGW IKGVLVRCML NIWGVMLFIR 300
  301 LSWIVGQAGI GLSVVVIAMA TVVTTITGLS TSAIATNGFV RGGGAYYLIS RSLGPEFGGA 360
  361 IGLIFAFANA VAVAMYVVGF AETVVELLKE HSILMIDEIN DIRIIGAITV VILLGISVAG 420
  421 MEWEAKAQIV LLVILLLAIA DFVIGTFISL ESKKPKGFFG YKSEIFNENF GPDFREEETF 480
  481 FSVFAIFFPA ATGILAGANI SGDLADPQSA IPKGTLLAIL ITTVVYIGIA VSVGSCVVRD 540
  541 ATGNVNDTIT TELTNCTSAA CKLNFDFSYC ESNTCSYGLM NNFQVMSMVS GFAPLISAGI 600
  601 FSATLSSALA SLVSAPKIFQ ALCKDNIYPA FQMFAKGYGK NNEPLRGYIL TFLIALGFIL 660
  661 IAELNVIAPI ISNFFLASYA LINFSVFHAS LAKSPGWRPA FKYYNMWISL IGAILCCIVM 720
  721 FVINWWAALL TYVIVLGLYI YVTYKKPDVN WGSSTQALTY LSALQHSIRL SGVEDHVKNF 780
  781 RPQCLVMTGS PNSRPALLHL VHDFTKNVGL MICGHVHMGP RRQAMKEMSI DQARYQRWLI 840
  841 KNKMKAFYAP VHADDLREGA QYLMQAAGLG RMKPNTLVLG FKKDWLQADM RDVDMYINLF 900
  901 HDAFDIQFGV VVIRLKEGLD ISHLQGQEEL LSSQEKSPGT KDVVVNVDYS KKSDQDTCKS 960
  961 SGEKSITQKD EEEDGKTPTQ PLLKKESKGP IVPLNVADQK LLEASTQFQK KQGKNTIDVW1020
 1021 WLFDDGGLTL LIPYLLTTKK KWKDCKIRVF IGGKINRIDH DRRAMATLLS KFRIDFSDIM1080
 1081 VLGDINTKPK KENIIAYDDM IEPYRLHEDD KEQDIADKMK EDEPWRITDN ELELYKTKTY1140
 1141 RQIRLNELLK EHSSTANIIV MSLPVARKGA VSSALYMAWL EALSKDLPPV LLVRGNHQSV1200
 1201 LTFYS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: S122_MOUSE, S12A...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: