Protein Overview: DNM3A_MOUSE

General Information:
Name(s) found:	DNM3A_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|74188648\|dbj\|BAE28067.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|74188590\|dbj\|BAE28043.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|74188565\|dbj\|BAE28033.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|74181067\|dbj\|BAE27806.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|6681209\|ref\|NP_031898.1\| DNA methyltransferase 3A isoform 1 [Mus musculus] [NCBI NR] gi\|6449468\|gb\|AAC40177.2\| DNA cytosine-5 methyltransferase 3A [Mus musculus] [NCBI NR] gi\|26354967\|dbj\|BAC41110.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|17374900\|sp\|O88508.2\|DNM3A_MOUSE RecName: Full=DNA (cytosine-5)-methyltransferase 3A; Short=Dnmt3a; AltName: Full=DNA methyltransferase MmuIIIA; Short=DNA MTase MmuIIIA; Short=M.MmuIIIA [NCBI NR] gi\|148669440\|gb\|EDL01387.1\| DNA methyltransferase 3A, isoform CRA_a [Mus musculus] [NCBI NR] DNA (cytosine-5)-methyltransferase 3A OS=Mus musculus GN=Dnmt3a PE=1 SV=2 [Swiss-Prot] (O88508) DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA) [Swiss-Prot] Ensembl_locations(Chr-bp):12-3701024 DNA [hmr_yeast5_DM3-1_pombe.fasta] DNA methyltransferase 3A [HMR_022704-rand.fasta] DNA methyltransferase 3A isoform 1 [071204_hmrz_cont.fasta] DNA methyltransferase 3A isoform 1 [Mus musculus]gi\|6449468\|gb\|AAC40177.2\| DNA cytosine-5 methyltransferase 3A [Mus musculus]gi\|26354967\|dbj\|BAC41110.1\| unnamed protein product [Mus musculus]gi\|17374900\|sp\|O88508\|DM3A_MOUSE DNA (cytosine-5)-methyltrans [nrdb_11152004_Chlamydomonas] (NM_007872) DNA methyltransferase 3A [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] DNA methyltransferase 3A isoform 1 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] DNA methyltransferase 3A, isoform CRA_a [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] DNA cytosine-5 methyltransferase 3A [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Dnmt3a Isoform 1 of DNA (cytosine-5)-methyltransferase 3A [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Dnmt3a Isoform 1 of DNA (cytosine-5)-methyltransferase 3A ENSMUSG00000020661 IPI00131694 IPI00172129 IPI00652899 IPI00404836 [IPIxENS.MOUSE_plus_REVERSE.fasta] DNA (cytosine-5)-methyltransferase 3A isoform 1 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta] IPI:IPI00131694.5\|SWISS-PROT:O88508-1\|ENSEMBL:ENSMUSP00000020991\|REFSEQ:NP_031898 Tax_Id=10090 Gene_Symbol=Dnmt3a Isoform 1 of DNA (cytosine-5)-methyltransferase 3A [ipi.MOUSE.fasta.20090209] Isoform 1 of DNA (cytosine-5)-methyltransferase 3A OS=Mus musculus GN=Dnmt3a [011711_HMR.fasta] sp\|O88508\|DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A OS=Mus musculus GN=Dnmt3a PE=1 SV=2 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	908 amino acids
Gene Ontology:
Cellular Component:	heterochromatin [IDA] nucleus [UNKNOWN][IDA] cytoplasm [IDA] chromosome, centromeric region [IDA] nuclear heterochromatin [IDA]
Biological Process:	chromatin modification [IEA] transcription [IEA] spermatogenesis [IMP] DNA methylation involved in gamete generation [IMP] DNA methylation involved in embryonic development [IEP][IMP] S-adenosylmethioninamine metabolic process [UNKNOWN] regulation of transcription [IEA] methylation-dependent chromatin silencing [IDA][IGI] negative regulation of transcription from RNA polymerase II promoter [IDA] regulation of gene expression by genetic imprinting [IMP] DNA methylation [IDA][IGI] S-adenosylhomocysteine metabolic process [UNKNOWN] DNA methylation on cytosine within a CG sequence [UNKNOWN]
Molecular Function:	DNA binding [IDA] DNA (cytosine-5-)-methyltransferase activity [IDA][IGI] zinc ion binding [IEA] protein binding [IPI] metal ion binding [IEA] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [UNKNOWN] methyltransferase activity [TAS] unmethylated CpG binding [UNKNOWN] chromatin binding [IDA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSGPGDTS SSSLEREDDR KEGEEQEENR GKEERQEPSA TARKVGRPGR KRKHPPVESS  60
   61 DTPKDPAVTT KSQPMAQDSG PSDLLPNGDL EKRSEPQPEE GSPAAGQKGG APAEGEGTET 120
  121 PPEASRAVEN GCCVTKEGRG ASAGEGKEQK QTNIESMKME GSRGRLRGGL GWESSLRQRP 180
  181 MPRLTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NAVEENQASG ESQKVEEASP 240
  241 PAVQQPTDPA SPTVATTPEP VGGDAGDKNA TKAADDEPEY EDGRGFGIGE LVWGKLRGFS 300
  301 WWPGRIVSWW MTGRSRAAEG TRWVMWFGDG KFSVVCVEKL MPLSSFCSAF HQATYNKQPM 360
  361 YRKAIYEVLQ VASSRAGKLF PACHDSDESD SGKAVEVQNK QMIEWALGGF QPSGPKGLEP 420
  421 PEEEKNPYKE VYTDMWVEPE AAAYAPPPPA KKPRKSTTEK PKVKEIIDER TRERLVYEVR 480
  481 QKCRNIEDIC ISCGSLNVTL EHPLFIGGMC QNCKNCFLEC AYQYDDDGYQ SYCTICCGGR 540
  541 EVLMCGNNNC CRCFCVECVD LLVGPGAAQA AIKEDPWNCY MCGHKGTYGL LRRREDWPSR 600
  601 LQMFFANNHD QEFDPPKVYP PVPAEKRKPI RVLSLFDGIA TGLLVLKDLG IQVDRYIASE 660
  661 VCEDSITVGM VRHQGKIMYV GDVRSVTQKH IQEWGPFDLV IGGSPCNDLS IVNPARKGLY 720
  721 EGTGRLFFEF YRLLHDARPK EGDDRPFFWL FENVVAMGVS DKRDISRFLE SNPVMIDAKE 780
  781 VSAAHRARYF WGNLPGMNRP LASTVNDKLE LQECLEHGRI AKFSKVRTIT TRSNSIKQGK 840
  841 DQHFPVFMNE KEDILWCTEM ERVFGFPVHY TDVSNMSRLA RQRLLGRSWS VPVIRHLFAP 900
  901 LKEYFACV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: DNM3A_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: