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Protein Overview: DNM3A_MOUSE

General Information:
Name(s) found: DNM3A_MOUSE [Swiss-Prot]
Description(s) found:
Found 27 descriptions.
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  • DNA (cytosine-5)-methyltransferase 3A OS=Mus musculus GN=Dnmt3a PE=1 SV=2 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 908 amino acids

    Gene Ontology:
    Cellular Component: heterochromatin [IDA]
    nucleus [UNKNOWN][IDA]
    cytoplasm [IDA]
    chromosome, centromeric region [IDA]
    nuclear heterochromatin [IDA]
    Biological Process: chromatin modification [IEA]
    transcription [IEA]
    spermatogenesis [IMP]
    DNA methylation involved in gamete generation [IMP]
    DNA methylation involved in embryonic development [IEPLink to PubMed article][IMP]
    S-adenosylmethioninamine metabolic process [UNKNOWN]
    regulation of transcription [IEA]
    methylation-dependent chromatin silencing [IDA][IGI]
    negative regulation of transcription from RNA polymerase II promoter [IDA]
    regulation of gene expression by genetic imprinting [IMP]
    DNA methylation [IDA][IGI]
    S-adenosylhomocysteine metabolic process [UNKNOWN]
    DNA methylation on cytosine within a CG sequence [UNKNOWN]
    Molecular Function: DNA binding [IDA]
    DNA (cytosine-5-)-methyltransferase activity [IDA][IGI]
    zinc ion binding [IEA]
    protein binding [IPI]
    metal ion binding [IEA]
    DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [UNKNOWN]
    methyltransferase activity [TAS]
    unmethylated CpG binding [UNKNOWN]
    chromatin binding [IDA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSGPGDTS SSSLEREDDR KEGEEQEENR GKEERQEPSA TARKVGRPGR KRKHPPVESS  60
   61 DTPKDPAVTT KSQPMAQDSG PSDLLPNGDL EKRSEPQPEE GSPAAGQKGG APAEGEGTET 120
  121 PPEASRAVEN GCCVTKEGRG ASAGEGKEQK QTNIESMKME GSRGRLRGGL GWESSLRQRP 180
  181 MPRLTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NAVEENQASG ESQKVEEASP 240
  241 PAVQQPTDPA SPTVATTPEP VGGDAGDKNA TKAADDEPEY EDGRGFGIGE LVWGKLRGFS 300
  301 WWPGRIVSWW MTGRSRAAEG TRWVMWFGDG KFSVVCVEKL MPLSSFCSAF HQATYNKQPM 360
  361 YRKAIYEVLQ VASSRAGKLF PACHDSDESD SGKAVEVQNK QMIEWALGGF QPSGPKGLEP 420
  421 PEEEKNPYKE VYTDMWVEPE AAAYAPPPPA KKPRKSTTEK PKVKEIIDER TRERLVYEVR 480
  481 QKCRNIEDIC ISCGSLNVTL EHPLFIGGMC QNCKNCFLEC AYQYDDDGYQ SYCTICCGGR 540
  541 EVLMCGNNNC CRCFCVECVD LLVGPGAAQA AIKEDPWNCY MCGHKGTYGL LRRREDWPSR 600
  601 LQMFFANNHD QEFDPPKVYP PVPAEKRKPI RVLSLFDGIA TGLLVLKDLG IQVDRYIASE 660
  661 VCEDSITVGM VRHQGKIMYV GDVRSVTQKH IQEWGPFDLV IGGSPCNDLS IVNPARKGLY 720
  721 EGTGRLFFEF YRLLHDARPK EGDDRPFFWL FENVVAMGVS DKRDISRFLE SNPVMIDAKE 780
  781 VSAAHRARYF WGNLPGMNRP LASTVNDKLE LQECLEHGRI AKFSKVRTIT TRSNSIKQGK 840
  841 DQHFPVFMNE KEDILWCTEM ERVFGFPVHY TDVSNMSRLA RQRLLGRSWS VPVIRHLFAP 900
  901 LKEYFACV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle