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Protein Overview: HA2B_MOUSE

General Information:
Name(s) found: HA2B_MOUSE [Swiss-Prot]
Description(s) found:
Found 27 descriptions.
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  • H-2 class II histocompatibility antigen, A-B alpha chain OS=Mus musculus GN=H2-Aa PE=1 SV=2 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 256 amino acids

    Gene Ontology:
    Cellular Component: MHC class II protein complex [IDA]
    membrane [IEA]
    integral to membrane [IEA]
    external side of plasma membrane [IDA]
    plasma membrane [IDA]
    lysosome [IDA]
    Biological Process: immune response [IEA]
    antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [IEA]
    positive regulation of T cell differentiation [IDA]
    antigen processing and presentation of peptide antigen [IDA]
    antigen processing and presentation [IDA]
    antigen processing and presentation of exogenous peptide antigen via MHC class II [IDA]
    Molecular Function: protein binding [IPI]
    peptide antigen binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRSRALILG VLALTTMLSL CGGEDDIEAD HVGTYGISVY QSPGDIGQYT FEFDGDELFY  60
   61 VDLDKKETVW MLPEFGQLAS FDPQGGLQNI AVVKHNLGVL TKRSNSTPAT NEAPQATVFP 120
  121 KSPVLLGQPN TLICFVDNIF PPVINITWLR NSKSVADGVY ETSFFVNRDY SFHKLSYLTF 180
  181 IPSDDDIYDC KVEHWGLEEP VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI 240
  241 IQGLRSGGTS RHPGPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..256] PSI-BLAST 53.221849 Class II MHC alpha chain, C-terminal domain; Class II MHC alpha chain, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptide antigen binding
    		•  11.0753660234769 bayes_pls_golite062009
  • olfactory receptor activity
    		•  8.50611980376815 bayes_pls_golite062009
  • antigen binding
    		•  7.67141746788228 bayes_pls_golite062009
  • endogenous lipid antigen binding
    		•  3.6120042602684 bayes_pls_golite062009
  • MHC class I receptor activity
    		•  3.46497995701625 bayes_pls_golite062009
  • receptor activity
    		•  3.04238248088254 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.91649681515985 bayes_pls_golite062009
  • natural killer cell lectin-like receptor binding
    		•  2.87337850935774 bayes_pls_golite062009
  • signal transducer activity
    		•  2.59970257426838 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.59970257426838 bayes_pls_golite062009
  • IgG binding
    		•  2.59905791929203 bayes_pls_golite062009
  • protein binding
    		•  2.20481087437436 bayes_pls_golite062009
  • binding
    		•  2.11682283742138 bayes_pls_golite062009
  • lipid antigen binding
    		•  2.09050740693882 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.37360564853216 bayes_pls_golite062009
  • growth factor binding
    		•  1.1520564031101 bayes_pls_golite062009
  • IgG receptor activity
    		•  1.15013317153047 bayes_pls_golite062009
  • receptor binding
    		•  0.96769592478452 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.962566971314929 bayes_pls_golite062009
  • exogenous lipid antigen binding
    		•  0.763929387638141 bayes_pls_golite062009
  • coreceptor activity
    		•  0.661209696849389 bayes_pls_golite062009
  • IgE receptor activity
    		•  0.54373753879821 bayes_pls_golite062009
  • IgE binding
    		•  0.54373753879821 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.4860421936 bayes_pls_golite062009
  • MHC class II receptor activity
    		•  0.251167772391909 bayes_pls_golite062009
  • peptide binding
    		•  0.2334349814724 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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