Protein Overview: ARG28_MOUSE

General Information:
Name(s) found:	ARG28_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|T30867 Rho-guanine nucleotide exchange factor - mouse [NCBI NR] gi\|7106395\|ref\|NP_036156.1\| Rho-guanine nucleotide exchange factor [Mus musculus] [NCBI NR] gi\|6225950\|sp\|P97433.1\|RGNEF_MOUSE RecName: Full=Rho-guanine nucleotide exchange factor; AltName: Full=p190RhoGEF; AltName: Full=Rho-interacting protein 2 [NCBI NR] gi\|1657835\|gb\|AAB18197.1\| Rho-guanine nucleotide exchange factor [Mus musculus] [NCBI NR] (P97433) Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2) [Swiss-Prot] Rho-guanine nucleotide exchange factor OS=Mus musculus GN=Rgnef PE=1 SV=1 [Swiss-Prot] Rho guanine nucleotide exchange factor 28 OS=Mus musculus GN=Arhgef28 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):13-94270741 Rho-guanine nucleotide exchange factor [hmr_yeast5_DM3-1_pombe.fasta] Rho-guanine nucleotide exchange factor; Rho interacting protein 2; Rho specific exchange factor [HMR_022704-rand.fasta] Rho-guanine nucleotide exchange factor [ipi.MOUSE.v3.06.fasta] Rho-guanine nucleotide exchange factor [Mus musculus]gi\|6225950\|sp\|P97433\|RGNE_MOUSE Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2)gi\|7513802\|pir\|\|T30867 Rho-guanine nucleotide exchange factor - mousegi\|1657835\|gb\|AA [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Rho-guanine nucleotide exchange factor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_012026) Rho interacting protein 2; DNA segment, Chr 13, Brigham & Women's Genetics 1089 expressed; Rho specific exchange factor [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Rho-guanine nucleotide exchange factor [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Rho-guanine nucleotide exchange factor (p190RhoGEF) (Rho-interacting protein 2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 RHO-GUANINE NUCLEOTIDE EXCHANGE FACTOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Rgnef Isoform 1 of Rho-guanine nucleotide exchange factor [mouse-ipi-250309-contam.fasta] Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2) [nr-271106-contam.fasta] IPI:IPI00875635.1\|SWISS-PROT:P97433-1\|ENSEMBL:ENSMUSP00000022166 Tax_Id=10090 Gene_Symbol=Rgnef Isoform 1 of Rho-guanine nucleotide exchange factor [ipi.MOUSE.fasta.20090209] Isoform 1 of Rho-guanine nucleotide exchange factor OS=Mus musculus GN=Rgnef [011711_HMR.fasta] sp\|P97433\|ARG28_MOUSE Rho guanine nucleotide exchange factor 28 OS=Mus musculus GN=Arhgef28 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1693 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA] membrane [IEA] plasma membrane [IEA] intracellular [IEA]
Biological Process:	regulation of Rho protein signal transduction [IEA] intracellular signaling pathway [IEA] central nervous system neuron axonogenesis [IMP] neurofilament cytoskeleton organization [IMP] cell differentiation [IEA]
Molecular Function:	RNA binding [IEA] protein binding [IPI] metal ion binding [IEA] guanyl-nucleotide exchange factor activity [IEA] Rho guanyl-nucleotide exchange factor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELSCSEVPL YGQKTVYAKF GKNVYLPEDA EFYFVYGGSH QRHVVIADRV QDNVLQSSIP  60
   61 GHWLQETVTV SVCLCSEGYS PVTMGSGSVT YVDNMACRLA RLLVTQADRL TACSHQTLLT 120
  121 PFALTVEALP ALDEELVLAL TQLELPLGWT VLGNSSLEVS LHRESLLHLA VRWALPKLFH 180
  181 FLLCLPGGVK ALKLPNEEAT TPLDLALQGG HSTLVEDITN FQGSHSPGFS RLRLNEEATL 240
  241 QFVHSSETLT LTVNHTAEHL LEADIKLFRK YFWDRAFLVK ALEQEAKTEK ATMPSGAAET 300
  301 EEEVRNLESG RSPSEEEEDA KSIKSQVDGP SEHEDQDRLA LDRSFDGLKK SKHVPASLAA 360
  361 GQLSDVLNGG DEVYANCMVI DQVGDLDINY INLEGLSTHT SPESGRSMLG PQACMHTLPP 420
  421 DTSPCGRPLI ENSEGTLDAA ASQSFVTPSS SRTSNLNLSF GLHGFEKEQS HLKKRSSSLD 480
  481 ALVADSEGEG GSEPPICYAV GSQSSPRTGL PSGDELDSFE TNTEPDCNIS RTESLSLSST 540
  541 LHSKESLLSG IRSRSYSCSS PKISSGKSRL VRDFTVCSTS EEQRSYSFQE PPGEKRIQEE 600
  601 EWDEYVIPAK SESEKYKVSR TFSFLMNRMT SPRNKSKMKN KDTKEKEKMN RHQFVPGTFS 660
  661 GVLQCSGCDK TLLGKESLQC ANCKANTHKG CKDAVPPCTK KFQEKYNKNK PQSILGSSSV 720
  721 RDVPAPGLSL HPSSSMPIGL PAGRKEFAAQ VHPLSRSVPG TTLESFRRAV TSLESEGDSW 780
  781 RSRSHSDELF QSMGSSPSTE SFMMEDVVDS SLWIDLSSDA QEFEAESWSL VVDPSFCSRQ 840
  841 EKDVIKRQDV IFELMQTEVH HIQTLLIMSE VFRKGMKEEL QLDHSTVDKI FPCLDELLET 900
  901 HRHFFFSMKE RRQESCAGSD RNFVINQIGD ILVQQFSEEN ASKMKRIYGE FCSHHKEAMS 960
  961 LFKELQQNKK FQNFIKIRNS NLLARRRGIP ECILLVTQRI TKYPVLVERI LQYTKERTEE1020
 1021 HRDLCKALGL IKDMIAAVDL KVSEYEKNQK WLEILNKIEN KTYTKLKNGH VFRKQALLSQ1080
 1081 ERALLHDGLV YWKTATGRFK DILALLLTDV LLFLQEKDQK YIFAAVDQKP SVISLQKLIA1140
 1141 REVANEERGM FLISASSAGP EMYEIHTNSK EERNNWMRRI QQAVESCPEE EGGRTSESDE1200
 1201 ERRKAEARVA KIQQCQEILS NQDQQICTYL EEKLHIYAEL GELSGFEDVH LEPHLLIKPD1260
 1261 PGEPPQAASL LAAALREAES LQVAVKASKM GDVSQSSEES PGGTVLMDTP STQDVPASPT1320
 1321 ASLVTEGTEG RGCWDVDPGL QGVVTDLAVS DAGEKVEYRS FSGSSQSEII QAIQNLTRLL1380
 1381 YSLQAALTIQ DSHIEIHKLV LQQRESLAPS HSFRGGPLQD QEKSRYLEKQ REELANIHKL1440
 1441 QHQFQQEQRR WHRTCDQQQR EQEAQESWLQ ARERECQSQE ELLLRHRSEL DHQLQEYQQS1500
 1501 LERLREGQRM VERERQKMRV QQGLLGHCKH SRQRSLPAVF SPGSKEVTEL NRAESLCHEN1560
 1561 SFFINEAFGH MSLNTSNKPN PSGVPWDAHP LEGSHFDLAR TSESPTELKI DISQPPDVNS1620
 1621 ELWTTGPGHQ RPALQENSKE SYKNVADLDS FQSESSSPQD SNQRWPPATD THNRSKTKSS1680
 1681 DGGWTRWRCW RRG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: ARG28_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: