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Protein Overview: CISH_MOUSE

General Information:
Name(s) found: CISH_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|74221184|dbj|BAE42087.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|74215325|dbj|BAE41877.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|74142807|dbj|BAE42448.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|6753426|ref|NP_034025.1| cytokine inducible SH2-containing protein [Mus musculus] [NCBI NR]
  • gi|26346214|dbj|BAC36758.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|18380950|gb|AAH22178.1| Cytokine inducible SH2-containing protein [Mus musculus] [NCBI NR]
  • gi|148689233|gb|EDL21180.1| cytokine inducible SH2-containing protein, isoform CRA_a [Mus musculus] [NCBI NR]
  • pir||S55551 cytokine-inducible protein CIS - mouse [NCBI NR]
  • gi|13277786|gb|AAH03783.1| Cytokine inducible SH2-containing protein [Mus musculus] [NCBI NR]
  • gi|13124068|sp|Q62225.1|CISH_MOUSE RecName: Full=Cytokine-inducible SH2-containing protein; Short=CIS; AltName: Full=CIS-1; AltName: Full=Suppressor of cytokine signaling; Short=SOCS [NCBI NR]
  • gi|1041129|dbj|BAA06713.1| cytokine inducible SH2-containing protein [Mus musculus] [NCBI NR]
  • Cytokine-inducible SH2-containing protein OS=Mus musculus GN=Cish PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):9-107473323 Cytokine-inducible SH2-containing protein [hmr_yeast5_DM3-1_pombe.fasta]
  • cytokine inducible SH2-containing protein; cytokine-inducible SH2 protein [HMR_022704-rand.fasta]
  • Cytokine-inducible SH2-containing protein [ipi.MOUSE.v3.06.fasta]
  • cytokine inducible SH2-containing protein [Mus musculus]gi|13277786|gb|AAH03783.1| Cytokine inducible SH2-containing protein [Mus musculus]gi|18380950|gb|AAH22178.1| Cytokine inducible SH2-containing protein [Mus musculus]gi|1363116|pir||S55551 cytokin [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Cytokine-inducible SH2-containing protein [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_009895) cytokine inducible SH2-containing protein; cytokine-inducible SH2 protein [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • cytokine inducible SH2-containing protein [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • cytokine inducible SH2-containing protein, isoform CRA_a [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Cytokine inducible SH2-containing protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Cish Cytokine-inducible SH2-containing protein [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Cish Cytokine-inducible SH2-containing protein ENSMUSG00000032578 IPI00123312 IPI00653320 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • cytokine-inducible SH2-containing protein [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00123312.1|SWISS-PROT:Q62225|TREMBL:Q8C3F4|ENSEMBL:ENSMUSP00000082183|REFSEQ:NP_034025 Tax_Id=10090 Gene_Symbol=Cish Cytokine-inducible SH2-containing protein [ipi.MOUSE.fasta.20090209]
  • Cytokine-inducible SH2-containing protein OS=Mus musculus GN=Cish [011711_HMR.fasta]
  • sp|Q62225|CISH_MOUSE Cytokine-inducible SH2-containing protein OS=Mus musculus GN=Cish PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 257 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDA]
    Biological Process: negative regulation of signal transduction [IEA]
    intracellular signaling pathway [IEA]
    activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IDA]
    regulation of growth [IEA]
    Molecular Function: protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLCVQGSCP LLAVEQIGRR PLWAQSLELP GPAMQPLPTG AFPEEVTEET PVQAENEPKV  60
   61 LDPEGDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 120
  121 KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCAAD TRSDSPDPAP 180
  181 TPALPMSKQD APSDSVLPIP VATAVHLKLV QPFVRRSSAR SLQHLCRLVI NRLVADVDCL 240
  241 PLPRRMADYL RQYPFQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..257] PSI-BLAST 33.69897 CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • binding
    		•  2.48735671726158 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.1238568876176 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64363774024605 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • receptor binding
    		•  1.52843393025918 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.39494498759145 bayes_pls_golite062009
  • kinase activity
    		•  1.31102709888086 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.24312972088703 bayes_pls_golite062009
  • growth hormone receptor binding
    		•  1.17624762106986 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.098112861344 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.950445630788802 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • protein complex binding
    		•  0.65988681496356 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.549336064224261 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.504702233623954 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.489780129542396 bayes_pls_golite062009
  • transferase activity
    		•  0.4880159130787 bayes_pls_golite062009
  • DNA binding
    		•  0.32481747214536 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.206747304356052 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.151092725944757 bayes_pls_golite062009
  • kinase binding
    		•  0.131981353175621 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0443241110585009 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle