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View Structure Prediction Details

Protein: CISH_MOUSE
Organism: Mus musculus
Length: 257 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CISH_MOUSE.

Description E-value Query
Range
Subject
Range
gi|149018620, gi... - ref|XP_343473.1| cytokine inducible SH2-containing protein [Rattus norvegicus], gi|198278490|ref|NP_...
196.0 [0..1] [257..1]
gi|63363 - gi|63363|emb|CAA31595.1| unnamed protein product [Gallus gallus]
191.0 [0..9] [252..68]
gi|66797 - gi|66797|pir||TVFVG9 protein-tyrosine kinase (EC 2.7.1.112) yes - avian sarcoma virus Y73
186.0 [0..13] [252..64]
gi|57089855 - gi|57089855|ref|XP_547654.1| PREDICTED: similar to Proto-oncogene tyrosine-protein kinase YES (p61-Y...
186.0 [0..36] [252..94]
gi|114672459 - gi|114672459|ref|XP_001147589.1| PREDICTED: viral oncogene yes-1 homolog 1 isoform 1 [Pan troglodyte...
186.0 [0..36] [252..96]
gi|154425902, gi... - gi|76651808|ref|XP_584279.2| PREDICTED: similar to Proto-oncogene tyrosine-protein kinase Yes (p61-Y...
186.0 [0..36] [252..94]

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Predicted Domain #1
Region A:
Residues: [1-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLCVQGSCP LLAVEQIGRR PLWAQSLELP GPAMQPLPTG AFPEEVTEET PVQAENEPKV  60
   61 LDPEGDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 120
  121 KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCAAD TRSDSPDPAP 180
  181 TPALPMSKQD APSDSVLPIP VATAVHLKLV QPFVRRSSAR SLQHLCRLVI NRLVADVDCL 240
  241 PLPRRMADYL RQYPFQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 2c9wA
Description: CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.19631993182765 bayes_pls_golite062009
molecular transducer activity 3.13508395312263 bayes_pls_golite062009
signal transducer activity 3.13508395312263 bayes_pls_golite062009
binding 2.48735671726158 bayes_pls_golite062009
insulin receptor binding 2.1238568876176 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
protein kinase activity 1.64363774024605 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
receptor binding 1.52843393025918 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.39494498759145 bayes_pls_golite062009
kinase activity 1.31102709888086 bayes_pls_golite062009
epidermal growth factor receptor binding 1.24312972088703 bayes_pls_golite062009
growth hormone receptor binding 1.17624762106986 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.098112861344 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.950445630788802 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
protein complex binding 0.65988681496356 bayes_pls_golite062009
nucleic acid binding 0.549336064224261 bayes_pls_golite062009
cytokine receptor binding 0.504702233623954 bayes_pls_golite062009
transcription regulator activity 0.489780129542396 bayes_pls_golite062009
transferase activity 0.4880159130787 bayes_pls_golite062009
DNA binding 0.32481747214536 bayes_pls_golite062009
protein tyrosine kinase activity 0.206747304356052 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 0.151092725944757 bayes_pls_golite062009
kinase binding 0.131981353175621 bayes_pls_golite062009
receptor signaling protein activity 0.0443241110585009 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle