Protein Overview: brp-PH, brp-PE, ...

General Information:
Name(s) found:	brp-PH / FBpp0289769 [FlyBase] brp-PE / FBpp0289194 [FlyBase] brp-PD / FBpp0289193 [FlyBase]
Description(s) found: Found 34 descriptions. SHOW ALL	The gene bruchpilot is referred to in FlyBase by the symbol Dmel\brp (CG42344, FBgn0259246). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5391293..5424980. It has the cytological map location 45E3-45F1. There is experimental evidence that it has the molecular function</span>: calcium channel activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; neuromuscular synaptic transmission; regulation of synaptic plasticity; neurotransmitter secretion; adult locomotory behavior; maintenance of presynaptic active zone structure. 22 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; larval neuromuscular junction. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene bruchpilot is referred to in FlyBase by the symbol Dmel\brp (CG42344, FBgn0259246). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5391293..5424980. It has the cytological map location 45E3-45F1. There is experimental evidence that it has the molecular function</span>: calcium channel activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; neuromuscular synaptic transmission; regulation of synaptic plasticity; neurotransmitter secretion; adult locomotory behavior; maintenance of presynaptic active zone structure. 22 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; larval neuromuscular junction. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene bruchpilot is referred to in FlyBase by the symbol Dmel\brp (CG42344, FBgn0259246). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5391293..5424980. It has the cytological map location 45E3-45F1. There is experimental evidence that it has the molecular function</span>: calcium channel activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; neuromuscular synaptic transmission; regulation of synaptic plasticity; neurotransmitter secretion; adult locomotory behavior; maintenance of presynaptic active zone structure. 22 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; larval neuromuscular junction. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1740 amino acids
Gene Ontology:
Cellular Component:	presynaptic membrane [IDA] presynaptic active zone [IDA] neuromuscular junction [IDA]
Biological Process:	maintenance of presynaptic active zone structure [IMP] neuromuscular synaptic transmission [IMP] regulation of synaptic plasticity [IMP] synaptic transmission [IMP] adult locomotory behavior [IMP] neurotransmitter secretion [IMP]
Molecular Function:	calcium channel activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSPYYRDMD EPTSPAGAGH HRSRSASRPP MAHAMDYPRT RYQSLDRGGL VDPHDREFIP  60
   61 IREPRDRSRD RSLERGLYLE DELYGRSARQ SPSAMGGYNT GMGPTSDRAY LGDLQHQNTD 120
  121 LQRELGNLKR ELELTNQKLG SSMHSIKTFW SPELKKERAL RKEESAKYSL INDQLKLLST 180
  181 ENQKQAMLVR QLEEELRLRM RQPNLEMQQQ MEAIYAENDH LQREISILRE TIKDLECRVE 240
  241 TQKQTLIARD ESIKKLLEML QAKGMGKEEE RQMFQQMQAM AQKQLDEFRL EIQRRDQEIL 300
  301 AMAAKMKTLE EQHQDYQRHI AVLKESLCAK EEHYNMLQTD VEEMRARLEE KNRLIEKKTQ 360
  361 GTLQTVQERN RLTSELTELK DHMDIKDRKI SVLQRKIENL EDLLKEKDNQ VDMARARLSA 420
  421 MQAHHSSSEG ALTSLEEAIG DKEKQMAQLR DQRDRAEHEK QEERDLHERE VADYKIKLRA 480
  481 AESEVEKLQT RLERAVTERE RLEIKLEASQ SELGKSKAEL EKATCEMGRS SADWESTKQR 540
  541 IARLELENER LKHDLERSQN VQKLMFETGK ISTTFGRTTM TTSQELDRAQ ERADKASAEL 600
  601 RRTQAELRVT QSDAERAREE AAALQEKLEK SQGEVYRLKA KLENAQGEQE SLRQELEKAQ 660
  661 SGVSRIHADR DRAFSEVEKI KEEMERTQAT LGKSQLQHEK LQNSLDKAQN EVDHLQDKLD 720
  721 KACTENRRLV LEKEKLTYDY DNLQSQLDKA LGQAARMQKE RETLSLDTDR IREKLEKTQV 780
  781 QLGRIQKERD QFSDELETLK ERSESAQTLL MKAARDREAM QTDLEVLKER YEKSHAIQQK 840
  841 LQMERDDAVT EVEILKEKLD KALYASQKLI DEKDTSNKEF EKMLEKYDRA QNEIYRLQSR 900
  901 CDTAEADRAR LEVEAERSGL AASKAREDLR KLQDESTRLQ EACDRAALQL SRAKECEDNA 960
  961 RSELEHSRDR FDKLQTDIRR AQGEKEHFQS ELERVTYELE RAHAAQTKAS ASVEAAKEEA1020
 1021 AHYAVELEKM RDRYEKSQVE LRKLQDTDTF GRETRRLKEE NERLREKLDK TLMELETIRG1080
 1081 KSQYESESFE KYKDKYEKIE MEVQNMESKL HETSLQLELS KGEVAKMLAN QEKQRSELER1140
 1141 AHIEREKARD KHEKLLKEVD RLRLQQSSVS PGDPVRASTS SSSALSAGER QEIDRLRDRL1200
 1201 EKALQSRDAT ELEAGRLAKE LEKAQMHLAK QQENTESTRI EFERMGAELG RLHDRLEKAE1260
 1261 AEREALRQAN RSGGAGAAPH PQLEKHVQKL ESDVKQLAME REQLVLQLEK SQEILMNFQK1320
 1321 ELQNAEAELQ KTREENRKLR NGHQVPPVAA PPAGPSPAEF QAMQKEIQTL QQKLQESERA1380
 1381 LQAAGPQQAQ AAAAAGASRE EIEQWRKVIE QEKSRADMAD KAAQEMHKRI QLMDQHIKDQ1440
 1441 HAQMQKMQQQ MQQQQQAAQQ AVQQAAQQQQ SAAGAGGADP KELEKVRGEL QAACTERDRF1500
 1501 QQQLELLVTE LEKSKMSNQE QAKQLQTAQQ QVQQLQQQVQ QLQQQMQQLQ QAASAGAGAT1560
 1561 DVQRQQLEQQ QKQLEEVRKQ IDNQAKATEG ERKIIDEQRK QIDAKRKDIE EKEKKMAEFD1620
 1621 VQLRKRKEQM DQLEKSLQTQ GGGAAAAGEL NKKLMDTQRQ LEACVKELQN TKEEHKKAAT1680
 1681 ETERLLQLVQ MSQEEQNAKE KTIMDLQQAL KIAQAKVKQA QTQQQQQQDA GPAGFLKSFF1740
 1741

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: brp-PH, brp-PE, ...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: