Protein Overview: AREG_MOUSE

General Information:
Name(s) found:	AREG_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|JH0612 amphiregulin precursor - mouse [NCBI NR] gi\|845599\|gb\|AAB00472.1\| amphiregulin [Mus musculus] [NCBI NR] gi\|71059969\|emb\|CAJ18528.1\| Areg [Mus musculus] [NCBI NR] gi\|6753108\|ref\|NP_033834.1\| amphiregulin preproprotein [Mus musculus] [NCBI NR] gi\|401074\|sp\|P31955.1\|AREG_MOUSE RecName: Full=Amphiregulin; Short=AR; AltName: Full=Schwannoma-derived growth factor; Short=SDGF; Flags: Precursor [NCBI NR] gi\|220600\|dbj\|BAA02169.1\| schwannoma-derived growth factor [Mus musculus] [NCBI NR] gi\|148673348\|gb\|EDL05295.1\| amphiregulin [Mus musculus] [NCBI NR] gi\|14318675\|gb\|AAH09138.1\| Amphiregulin [Mus musculus] [NCBI NR] gi\|12858375\|dbj\|BAB31296.1\| unnamed protein product [Mus musculus] [NCBI NR] Amphiregulin OS=Mus musculus GN=Areg PE=2 SV=1 [Swiss-Prot] (P31955) Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF) [Swiss-Prot] Ensembl_locations(Chr-bp):5-90448304 Schwannoma-derived growth factor precursor [hmr_yeast5_DM3-1_pombe.fasta] amphiregulin preproprotein [HMR_022704-rand.fasta] Amphiregulin precursor [ipi.MOUSE.v3.06.fasta] amphiregulin preproprotein [Mus musculus]gi\|14318675\|gb\|AAH09138.1\| Amphiregulin, preproprotein [Mus musculus]gi\|220600\|dbj\|BAA02169.1\| schwannoma-derived growth factor [Mus musculus]gi\|401074\|sp\|P31955\|SDGF_MOUSE Schwannoma-derived growth factor precu [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Amphiregulin precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_009704) amphiregulin preproprotein [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] amphiregulin preproprotein [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] amphiregulin [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Amphiregulin [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Areg [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] schwannoma-derived growth factor [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] amphiregulin [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 AMPHIREGULIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Areg Amphiregulin [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Areg Amphiregulin precursor [ipi.MOUSE_jw_12may08.contam.fasta] Tax_Id=10090 Gene_Symbol=Areg Amphiregulin precursor ENSMUSG00000029378 IPI00109922 [IPIxENS.MOUSE_plus_REVERSE.fasta] IPI:IPI00109922.1\|SWISS-PROT:P31955\|TREMBL:Q4FJT2\|ENSEMBL:ENSMUSP00000031325\|REFSEQ:NP_033834 Tax_Id=10090 Gene_Symbol=Areg Amphiregulin [ipi.MOUSE.fasta.20090209] Amphiregulin OS=Mus musculus GN=Areg [011711_HMR.fasta] sp\|P31955\|AREG_MOUSE Amphiregulin OS=Mus musculus GN=Areg PE=2 SV=1 [uniprot.sptr.mouse.20130102] tr\|Q4FJT2\|Q4FJT2_MOUSE Amphiregulin OS=Mus musculus GN=Areg PE=2 SV=1 [uniprot.sptr.mouse.20130102] Isoform of P31955, Amphiregulin OS=Mus musculus GN=Areg PE=2 SV=1 [MOUSE.fasta.20160308]
Organism:	Mus musculus
Length:	248 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] extracellular space [UNKNOWN] cytoplasm [IDA] membrane [IEA] integral to membrane [IEA] intracellular [IDA]
Biological Process:	positive regulation of phosphorylation [UNKNOWN] epithelial cell proliferation involved in mammary gland duct elongation [IMP] mammary gland alveolus development [IGI] neuron projection development [UNKNOWN] epidermal growth factor receptor signaling pathway [UNKNOWN] positive regulation of cell proliferation [UNKNOWN] response to glucocorticoid stimulus [UNKNOWN] response to estradiol stimulus [IDA] glial cell proliferation [UNKNOWN] dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis [IMP] negative regulation of osteoblast differentiation [UNKNOWN] mammary gland branching involved in thelarche [IMP]
Molecular Function:	growth factor activity [UNKNOWN] epidermal growth factor receptor binding [UNKNOWN] cytokine activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTPLLPLAR SVLLLLVLGS GHYAAALELN DPSSGKGESL SGDHSAGGLE LSVGREVSTI  60
   61 SEMPSGSELS TGDYDYSEEY DNEPQISGYI IDDSVRVEQV IKPKKNKTEG EKSTEKPKRK 120
  121 KKGGKNGKGR RNKKKKNPCT AKFQNFCIHG ECRYIENLEV VTCNCHQDYF GERCGEKSMK 180
  181 THSEDDKDLS KIAVVAVTIF VSAIILAAIG IGIVITVHLW KRYFREYEGE TEERRRLRQE 240
  241 NGTVHAIA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..248]	PSI-BLAST	5.154902	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains

Protein Overview: AREG_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: