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Protein Overview: AREG_MOUSE

General Information:
Name(s) found: AREG_MOUSE [Swiss-Prot]
Description(s) found:
Found 34 descriptions.
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  • Amphiregulin OS=Mus musculus GN=Areg PE=2 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 248 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    extracellular space [UNKNOWN]
    cytoplasm [IDA]
    membrane [IEA]
    integral to membrane [IEA]
    intracellular [IDA]
    Biological Process: positive regulation of phosphorylation [UNKNOWN]
    epithelial cell proliferation involved in mammary gland duct elongation [IMP]
    mammary gland alveolus development [IGI]
    neuron projection development [UNKNOWN]
    epidermal growth factor receptor signaling pathway [UNKNOWN]
    positive regulation of cell proliferation [UNKNOWN]
    response to glucocorticoid stimulus [UNKNOWN]
    response to estradiol stimulus [IDA]
    glial cell proliferation [UNKNOWN]
    dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis [IMP]
    negative regulation of osteoblast differentiation [UNKNOWN]
    mammary gland branching involved in thelarche [IMP]
    Molecular Function: growth factor activity [UNKNOWN]
    epidermal growth factor receptor binding [UNKNOWN]
    cytokine activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTPLLPLAR SVLLLLVLGS GHYAAALELN DPSSGKGESL SGDHSAGGLE LSVGREVSTI  60
   61 SEMPSGSELS TGDYDYSEEY DNEPQISGYI IDDSVRVEQV IKPKKNKTEG EKSTEKPKRK 120
  121 KKGGKNGKGR RNKKKKNPCT AKFQNFCIHG ECRYIENLEV VTCNCHQDYF GERCGEKSMK 180
  181 THSEDDKDLS KIAVVAVTIF VSAIILAAIG IGIVITVHLW KRYFREYEGE TEERRRLRQE 240
  241 NGTVHAIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..248] PSI-BLAST 5.154902 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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