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Protein Overview: CA12

General Information:
Name(s) found: CA12 [HGNC (HUGO)]
Description(s) found:
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  • gi|5915866|sp|O43570.1|CAH12_HUMAN RecName: Full=Carbonic anhydrase 12; AltName: Full=Carbonic anhydrase XII; Short=CA-XII; AltName: Full=Carbonate dehydratase XII; AltName: Full=HOM-RCC-3.1.3 tumor antigen; Flags: Precursor [NCBI NR]
  • gi|4502515|ref|NP_001209.1| carbonic anhydrase XII isoform 1 precursor [Homo sapiens] [NCBI NR]
  • gi|2984693|gb|AAC39789.1| carbonic anhydrase XII precursor [Homo sapiens] [NCBI NR]
  • gi|2708639|gb|AAC63952.1| carbonic anhydrase precursor [Homo sapiens] [NCBI NR]
  • gi|18645129|gb|AAH23981.1| Carbonic anhydrase XII [Homo sapiens] [NCBI NR]
  • gi|119598052|gb|EAW77646.1| carbonic anhydrase XII, isoform CRA_a [Homo sapiens] [NCBI NR]
  • carbonic anhydrase XII [HGNC (HUGO)]
  • (O43570) Carbonic anhydrase XII precursor (EC 4.2.1.1) (Carbonate dehydratase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) [Swiss-Prot]
  • Carbonic anhydrase 12 OS=Homo sapiens GN=CA12 PE=1 SV=1 [Swiss-Prot]
  • Splice isoform 1 of O43570 [hmr_yeast5_DM3-1_pombe.fasta]
  • carbonic anhydrase XII isoform 1 precursor; carbonic dehydratase [HMR_022704.fasta]
  • carbonic anhydrase XII isoform 1 precursor [Homo sapiens]gi|18645129|gb|AAH23981.1| Carbonic anhydrase XII, isoform 1 precursor [Homo sapiens]gi|2708639|gb|AAC63952.1| carbonic anhydrase precursor [Homo sapiens]gi|2984693|gb|AAC39789.1| carbonic anhydr [nrdb_11152004_Chlamydomonas]
  • Carbonic anhydrase XII precursor (Carbonate dehydratase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Carbonic anhydrase 12 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_001218) carbonic anhydrase XII precursor; carbonic dehydratase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • carbonic anhydrase XII isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Carbonic anhydrase XII precursor [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • carbonic anhydrase XII isoform 1 precursor; carbonic dehydratase [Homo sapiens] [HumanGallus06162005.fasta]
  • carbonic anhydrase XII precursor; carbonic dehydratase [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Carbonic anhydrase 12 precursor (Carbonic anhydrase XII) (CA-XII) (Carbonate dehydratase XII) (Tumor antigen HOM-RCC-3.1.3) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Carbonic anhydrase XII [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • carbonic anhydrase XII, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • carbonic anhydrase precursor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • carbonic anhydrase XII precursor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Carbonic anhydrase 12 precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF CARBONIC ANHYDRASE XII PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Carbonic anhydrase 12; AltName: Full=Carbonic anhydrase XII; Short=CA-XII; AltName: Full=Carbonate dehydratase XII; AltName: Full=HOM-RCC-3.1.3 tumor antigen; Flags: Precursor [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CA12 Isoform 1 of Carbonic anhydrase 12 [human-ipi-250309-contam.fasta]
  • Carbonic anhydrase 12 precursor (Carbonic anhydrase XII) (Carbonate dehydratase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) [nr-271106-contam.fasta]
  • IPI:IPI00012895.3|SWISS-PROT:O43570-1|TREMBL:B2RE24|ENSEMBL:ENSP00000178638|REFSEQ:NP_001209|H-INV:HIT000039706|VEGA:OTTHUMP00000163786;OTTHUMP00000176366 Tax_Id=9606 Gene_Symbol=CA12 Isoform 1 of Carbonic anhydrase 12 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=CA12 Isoform 1 of Carbonic anhydrase 12 precursor ENSG00000074410 IPI00012895 IPI00221392 IPI00014957 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CA12 Isoform 1 of Carbonic anhydrase 12 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • carbonic anhydrase 12 isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • O43570;Q53YE5;Q9BWG2; RecName: Full=Carbonic anhydrase 12; AltName: Full=Carbonic anhydrase XII; AltName: Full=Carbonate dehydratase XII; AltName: Full=Tumor antigen HOM-RCC-3.1.3; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Carbonic anhydrase 12 OS=Homo sapiens GN=CA12 [011711_HMR.fasta]
  • GeneSymbol=CA12 Synonyms=CAXII|FLJ20151|HsT18816 carbonic anhydrase 12 isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00012895.3|SWISS-PROT:O43570-1|TREMBL:B2RE24|ENSEMBL:ENSP00000178638|REFSEQ:NP_001209|H-INV:HIT000039706|VEGA:OTTHUMP00000163786 Tax_Id=9606 Gene_Symbol=CA12 Isoform 1 of Carbonic anhydrase 12 [ipi.HUMAN.20110912.fasta]
  • Carbonic anhydrase 12 GN=CA12 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 354 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL  60
   61 HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120
  121 HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180
  181 PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240
  241 NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL 300
  301 SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..354] PSI-BLAST 91.0 Carbonic anhydrase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • carbonate dehydratase activity
    		•  2.35405414226159 bayes_pls_golite062009
  • binding
    		•  1.59667704693142 bayes_pls_golite062009
  • protein binding
    		•  1.30419076438266 bayes_pls_golite062009
  • catalytic activity
    		•  0.97285738666961 bayes_pls_golite062009
  • zinc ion binding
    		•  0.744428270762821 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.36067052386032 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.0641135521348118 bayes_pls_golite062009
  • hydro-lyase activity
    		•  0.0479238316186823 bayes_pls_golite062009
  • lyase activity
    		•  0.0337150119314038 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle