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Protein Overview: TDP1

General Information:
Name(s) found: TDP1 [HGNC (HUGO)]
Description(s) found:
Found 30 descriptions.
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  • tyrosyl-DNA phosphodiesterase 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 608 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE AQKAAHKRKI  60
   61 SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM PQKQAEKVVI KKEKDISAPN 120
  121 DGTAQRTENH GAPACHRLKE EEDEYETSGE GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS 180
  181 GALHIKDILS PLFGTLVSSA QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA 240
  241 QAKPYENISL CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP 300
  301 LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET NVYLIGSTPG 360
  361 RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS VGSLGADESK WLCSEFKESM 420
  421 LTLGKESKTP GKSSVPLYLI YPSVENVRTS LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW 480
  481 SAETSGRSNA MPHIKTYMRP SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG 540
  541 VLFLPSAFGL DSFKVKQKFF AGSQEPMATF PVPYDLPPEL YGSKDRPWIW NIPYVKAPDT 600
  601 HGNMWVPS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] FFAS03 1.6 No description for 2j63A was found.
    2 View Details [151..608] PSI-BLAST 1000.0 Tyrosyl-DNA phosphodiesterase TDP1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • 3'-tyrosyl-DNA phosphodiesterase activity
    		•  1.46693175347055 bayes_pls_golite062009
  • tyrosyl-DNA phosphodiesterase activity
    		•  1.46693175347055 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.41591686174898 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.29668490323599 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.29429720882252 bayes_pls_golite062009
  • catalytic activity
    		•  1.29236214516383 bayes_pls_golite062009
  • binding
    		•  1.26667168593698 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.926017334343152 bayes_pls_golite062009
  • DNA binding
    		•  0.840595330626189 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.235198647671849 bayes_pls_golite062009
  • protein binding
    		•  0.162885453822356 bayes_pls_golite062009
  • kinase activity
    		•  0.10314500262782 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle