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Protein Overview: GJA8

General Information:
Name(s) found: GJA8 [HGNC (HUGO)]
Description(s) found:
Found 27 descriptions.
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  • gap junction protein, alpha 8, 50kDa [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 433 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS DFVCNTQQPG  60
   61 CENVCYDEAF PISHIRLWVL QIIFVSTPSL MYVGHAVHYV RMEEKRKSRE AEELGQQAGT 120
  121 NGGPDQGSVK KSSGSKGTKK FRLEGTLLRT YICHIIFKTL FEVGFIVGHY FLYGFRILPL 180
  181 YRCSRWPCPN VVDCFVSRPT EKTIFILFML SVASVSLFLN VMELGHLGLK GIRSALKRPV 240
  241 EQPLGEIPEK SLHSIAVSSI QKAKGYQLLE EEKIVSHYFP LTEVGMVETS PLPAKPFNQF 300
  301 EEKISTGPLG DLSRGYQETL PSYAQVGAQE VEGEGPPAEE GAEPEVGEKK EEAERLTTEE 360
  361 QEKVAVPEGE KVETPGVDKE GEKEEPQSEK VSKQGLPAEK TPSLCPELTT DDARPLSRLS 420
  421 KASSRARSDD LTV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] Pfam 89.823909 No description for PF00029.10 was found. No confident structure predictions are available.
    2 View Details [138..243] MSA 4.152982 View MSA. No confident structure predictions are available.
    3 View Details [244..433] PSI-BLAST 16.30103 Connexin 43 Carboxyl Terminal Domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • gap junction channel activity
    		•  8.7394469748353 bayes_pls_golite062009
  • gap junction hemi-channel activity
    		•  6.07792310007804 bayes_pls_golite062009
  • channel activity
    		•  3.3317557399613 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  3.3317557399613 bayes_pls_golite062009
  • transporter activity
    		•  2.93091397928047 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.82224868778929 bayes_pls_golite062009
  • gated channel activity
    		•  2.71019001063999 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.13986461397239 bayes_pls_golite062009
  • signal transducer activity
    		•  2.13986461397239 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  2.0179028116167 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.72732246293743 bayes_pls_golite062009
  • PDZ domain binding
    		•  1.67572965812401 bayes_pls_golite062009
  • binding
    		•  1.64221234725269 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.59907041714577 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.48329840603397 bayes_pls_golite062009
  • wide pore channel activity
    		•  1.20772405672681 bayes_pls_golite062009
  • receptor binding
    		•  0.64895976014223 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.49888190331002 bayes_pls_golite062009
  • SH3 domain binding
    		•  0.0507592042406799 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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