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Protein Overview: M6PR

General Information:
Name(s) found: M6PR [HGNC (HUGO)]
Description(s) found:
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  • gi|8546849|emb|CAB94715.1| 46kd mannose 6-phosphate receptor [Homo sapiens] [NCBI NR]
  • gi|45708396|gb|AAH24206.1| Mannose-6-phosphate receptor (cation dependent) [Homo sapiens] [NCBI NR]
  • gi|4505061|ref|NP_002346.1| cation-dependent mannose-6-phosphate receptor precursor [Homo sapiens] [NCBI NR]
  • gi|307147|gb|AAA59542.1| mannose 6-phosphate-specific receptor protein precursor [Homo sapiens] [NCBI NR]
  • gi|158255722|dbj|BAF83832.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|127293|sp|P20645.1|MPRD_HUMAN RecName: Full=Cation-dependent mannose-6-phosphate receptor; Short=CD Man-6-P receptor; Short=CD-MPR; AltName: Full=46 kDa mannose 6-phosphate receptor; AltName: Full=MPR 46; Flags: Precursor [NCBI NR]
  • gi|119609005|gb|EAW88599.1| mannose-6-phosphate receptor (cation dependent), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119609004|gb|EAW88598.1| mannose-6-phosphate receptor (cation dependent), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119609003|gb|EAW88597.1| mannose-6-phosphate receptor (cation dependent), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119609002|gb|EAW88596.1| mannose-6-phosphate receptor (cation dependent), isoform CRA_a [Homo sapiens] [NCBI NR]
  • pir||A32700 mannose 6-phosphate receptor, cation-dependent, precursor - human [NCBI NR]
  • mannose-6-phosphate receptor (cation dependent) [HGNC (HUGO)]
  • Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens GN=M6PR PE=1 SV=1 [Swiss-Prot]
  • Cation-dependent mannose-6-phosphate receptor precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • cation-dependent mannose-6-phosphate receptor precursor; Mr 46,000 Man6PR; 46-kDa mannose 6-phosphate receptor [HMR_022704.fasta]
  • cation-dependent mannose-6-phosphate receptor precursor; 46-kDa mannose 6-phosphate receptor; Mr 46,000 Man6PR [Human2242005.fasta]
  • cation-dependent mannose-6-phosphate receptor precursor [Homo sapiens]gi|45708396|gb|AAH24206.1| Cation-dependent mannose-6-phosphate receptor, precursor [Homo sapiens]gi|127293|sp|P20645|MPRD_HUMAN Cation-dependent mannose-6-phosphate receptor precurso [nrdb_11152004_Chlamydomonas]
  • Cation-dependent mannose-6-phosphate receptor precursor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Cation-dependent mannose-6-phosphate receptor precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_002355) cation-dependent mannose-6-phosphate receptor precursor; Mr 46,000 Man6PR; 46-kDa mannose 6-phosphate receptor [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • cation-dependent mannose-6-phosphate receptor precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • cation-dependent mannose-6-phosphate receptor precursor; 46-kDa mannose 6-phosphate receptor; Mr 46,000 Man6PR [Homo sapiens] [HumanGallus06162005.fasta]
  • cation-dependent mannose-6-phosphate receptor precursor; Mr 46,000 Man6PR; 46-kDa mannose 6-phosphate receptor [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • mannose-6-phosphate receptor (cation dependent), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 46kd mannose 6-phosphate receptor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Mannose-6-phosphate receptor (cation dependent) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • mannose 6-phosphate-specific receptor protein precursor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 CATION-DEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Cation-dependent mannose-6-phosphate receptor; Short=CD Man-6-P receptor; Short=CD-MPR; AltName: Full=46 kDa mannose 6-phosphate receptor; AltName: Full=MPR 46; Flags: Precursor [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=M6PR Cation-dependent mannose-6-phosphate receptor [human-ipi-250309-contam.fasta]
  • IPI:IPI00025049.1|SWISS-PROT:P20645|TREMBL:A8K528;B2R6S2;Q53GY9;Q6I9U3;Q96AH2|ENSEMBL:ENSP00000000412|REFSEQ:NP_002346|H-INV:HIT000258970|VEGA:OTTHUMP00000166568 Tax_Id=9606 Gene_Symbol=M6PR Cation-dependent mannose-6-phosphate receptor [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=M6PR Cation-dependent mannose-6-phosphate receptor precursor ENSG00000003056 IPI00025049 IPI00796659 IPI00797313 IPI00795395 IPI00796031 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=M6PR Cation-dependent mannose-6-phosphate receptor precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P20645;A8K528; RecName: Full=Cation-dependent mannose-6-phosphate receptor; AltName: Full=46 kDa mannose 6-phosphate receptor; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens GN=M6PR [011711_HMR.fasta]
  • IPI:IPI00025049.1|SWISS-PROT:P20645|TREMBL:B2R6S2;D3DUV5;Q53GY9;Q6I9U3;Q96AH2|ENSEMBL:ENSP00000000412|REFSEQ:NP_002346|H-INV:HIT000258970|VEGA:OTTHUMP00000166568 Tax_Id=9606 Gene_Symbol=M6PR Cation-dependent mannose-6-phosphate receptor [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=M6PR Synonyms=CD-MPR|FLJ32994|MPR 46|MPR-46|MPR46|SMPR cation-dependent mannose-6-phosphate receptor precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00025049.1|SWISS-PROT:P20645|TREMBL:B2R6S2;Q53GY9;Q6I9U3;Q96AH2|ENSEMBL:ENSP00000000412|REFSEQ:NP_002346|H-INV:HIT000258970|VEGA:OTTHUMP00000238493 Tax_Id=9606 Gene_Symbol=M6PR Cation-dependent mannose-6-phosphate receptor [ipi.HUMAN.20110912.fasta]
  • Cation-dependent mannose-6-phosphate receptor GN=M6PR [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 277 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF  60
   61 ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE TVVGRLNETH IFNGSNWIML 120
  121 IYKGGDEYDN HCGKEQRRAV VMISCNRHTL ADNFNPVSEE RGKVQDCFYL FEMDSSLACS 180
  181 PEISHLSVGS ILLVTFASLV AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC 240
  241 DFVCRSKPRN VPAAYRGVGD DQLGEESEER DDHLLPM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 47.30103 Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain
    2 View Details [186..277] Pfam 10.677781 No description for PF02157.6 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor activity
    		•  2.16567725130191 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.7623085294263 bayes_pls_golite062009
  • binding
    		•  1.63474009393214 bayes_pls_golite062009
  • mannose binding
    		•  1.47777842440942 bayes_pls_golite062009
  • glycoprotein binding
    		•  1.21372567656775 bayes_pls_golite062009
  • protein binding
    		•  1.14178057175691 bayes_pls_golite062009
  • growth factor binding
    		•  1.13825996944044 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07094403673351 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07094403673351 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.93864424825473 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.87739040385088 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.787496317925942 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.38688318553501 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle