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Protein Overview: EFNA4

General Information:
Name(s) found: EFNA4 [HGNC (HUGO)]
Description(s) found:
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  • gi|77567634|gb|AAI07484.1| Ephrin-A4 [Homo sapiens] [NCBI NR]
  • pir||I38850 LERK-4 - human [NCBI NR]
  • gi|642835|gb|AAC50079.1| LERK-4 [Homo sapiens] [NCBI NR]
  • gi|55962184|emb|CAI15316.1| ephrin-A4 [Homo sapiens] [NCBI NR]
  • gi|49065564|emb|CAG38600.1| EFNA4 [Homo sapiens] [NCBI NR]
  • gi|4885197|ref|NP_005218.1| ephrin A4 isoform a [Homo sapiens] [NCBI NR]
  • gi|3821235|emb|CAA06992.1| ephrin-A4 [Homo sapiens] [NCBI NR]
  • gi|1706672|sp|P52798.1|EFNA4_HUMAN RecName: Full=Ephrin-A4; AltName: Full=EPH-related receptor tyrosine kinase ligand 4; Short=LERK-4; Flags: Precursor [NCBI NR]
  • gi|119573525|gb|EAW53140.1| ephrin-A4, isoform CRA_c [Homo sapiens] [NCBI NR]
  • ephrin-A4 [HGNC (HUGO)]
  • Ephrin-A4 OS=Homo sapiens GN=EFNA4 PE=1 SV=1 [Swiss-Prot]
  • (P52798) Ephrin-A4 precursor (EPH-related receptor tyrosine kinase ligand 4) (LERK-4) [Swiss-Prot]
  • Splice isoform 1 of P52798 [hmr_yeast5_DM3-1_pombe.fasta]
  • ephrin A4 isoform a; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4 [HMR_022704.fasta]
  • ephrin A4 isoform a [Homo sapiens]gi|642835|gb|AAC50079.1| LERK-4 [Homo sapiens]gi|7448006|pir||I38850 LERK-4 - humangi|3821235|emb|CAA06992.1| ephrin-A4 [Homo sapiens]gi|49065564|emb|CAG38600.1| EFNA4 [Homo sapiens]gi|1706672|sp|P52798|EFA4_HUMAN Ep [nrdb_11152004_Chlamydomonas]
  • Ephrin-A4 precursor (EPH-related receptor tyrosine kinase ligand 4) (LERK-4) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Ephrin-A4 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005227) ephrin-A4; eph-related receptor tyrosine kinase ligand 4 (ephrin-A4); eph-related receptor tyrosine kinase ligand 4 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • ephrin A4 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • ephrin A4 isoform a; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4 [Homo sapiens] [HumanGallus06162005.fasta]
  • ephrin-A4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ephrin-A4, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ephrin-A4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • EFNA4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • LERK-4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Ephrin-A4 precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF EPHRIN-A4 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=EFNA4 Isoform 1 of Ephrin-A4 [human-ipi-250309-contam.fasta]
  • IPI:IPI00005125.1|SWISS-PROT:P52798-1|ENSEMBL:ENSP00000357394|REFSEQ:NP_005218|H-INV:HIT000244105|VEGA:OTTHUMP00000033237 Tax_Id=9606 Gene_Symbol=EFNA3;EFNA4 Isoform 1 of Ephrin-A4 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=EFNA4 Isoform 1 of Ephrin-A4 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P52798;O95457;Q5SR71;Q6FI57; RecName: Full=Ephrin-A4; AltName: Full=EPH-related receptor tyrosine kinase ligand 4; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Ephrin-A4 OS=Homo sapiens GN=EFNA4 [011711_HMR.fasta]
  • IPI:IPI00005125.1|SWISS-PROT:P52798-1|ENSEMBL:ENSP00000357394|REFSEQ:NP_005218|H-INV:HIT000244105|VEGA:OTTHUMP00000033237 Tax_Id=9606 Gene_Symbol=EFNA4 Isoform 1 of Ephrin-A4 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=EFNA4 Synonyms=EFL4|EPLG4|FLJ57652|LERK4|MGC125826 ephrin-A4 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00005125.1|SWISS-PROT:P52798-1|ENSEMBL:ENSP00000357394|REFSEQ:NP_005218|VEGA:OTTHUMP00000033237 Tax_Id=9606 Gene_Symbol=EFNA4 Isoform 1 of Ephrin-A4 [ipi.HUMAN.20110912.fasta]
  • Ephrin-A4 GN=EFNA4 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 201 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLPLLRTV LWAAFLGSPL RGGSSLRHVV YWNSSNPRLL RGDAVVELGL NDYLDIVCPH  60
   61 YEGPGPPEGP ETFALYMVDW PGYESCQAEG PRAYKRWVCS LPFGHVQFSE KIQRFTPFSL 120
  121 GFEFLPGETY YYISVPTPES SGQCLRLQVS VCCKERKSES AHPVGSPGES GTSGWRGGDT 180
  181 PSPLCLLLLL LLLILRLLRI L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] PSI-BLAST 53.045757 EphB2 / EphrinA5 Complex Structure

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ephrin receptor binding
    		•  2.36859280211986 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.36323002598215 bayes_pls_golite062009
  • transporter activity
    		•  2.349332206525 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.33073133834369 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.32480642400158 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.29776380543181 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.29241843776882 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.06651640066545 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.99582660272933 bayes_pls_golite062009
  • receptor activity
    		•  1.91940799510612 bayes_pls_golite062009
  • chemorepellent activity
    		•  1.90814130005669 bayes_pls_golite062009
  • copper ion binding
    		•  1.80505490229579 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.75949499317195 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.62698854419438 bayes_pls_golite062009
  • signal transducer activity
    		•  1.56471564066129 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.56471564066129 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.56305555927578 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.53842870476418 bayes_pls_golite062009
  • receptor binding
    		•  1.37212317927386 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.14077883686505 bayes_pls_golite062009
  • binding
    		•  1.13644448710023 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.63330965564582 bayes_pls_golite062009
  • ephrin receptor activity
    		•  0.605684209141979 bayes_pls_golite062009
  • protein binding
    		•  0.2916630712244 bayes_pls_golite062009
  • transmembrane-ephrin receptor activity
    		•  0.188547409516379 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle