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Protein Overview: GDNF

General Information:
Name(s) found: GDNF [HGNC (HUGO)]
Description(s) found:
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  • gi|729567|sp|P39905.1|GDNF_HUMAN RecName: Full=Glial cell line-derived neurotrophic factor; AltName: Full=Astrocyte-derived trophic factor; Short=ATF; Short=hGDNF; Flags: Precursor [NCBI NR]
  • gi|49456801|emb|CAG46721.1| GDNF [Homo sapiens] [NCBI NR]
  • pir||B37499 glial cell line-derived neurotrophic factor precursor - human [NCBI NR]
  • gi|47480729|gb|AAH69369.1| Glial cell derived neurotrophic factor [Homo sapiens] [NCBI NR]
  • gi|46575628|gb|AAH69119.1| Glial cell derived neurotrophic factor [Homo sapiens] [NCBI NR]
  • gi|4503975|ref|NP_000505.1| glial cell derived neurotrophic factor isoform 1 preproprotein [Homo sapiens] [NCBI NR]
  • gi|306763|gb|AAA67910.1| neurotrophic factor [NCBI NR]
  • gi|118763995|gb|AAI28109.1| Glial cell derived neurotrophic factor [Homo sapiens] [NCBI NR]
  • gi|118763576|gb|AAI28110.1| Glial cell derived neurotrophic factor [Homo sapiens] [NCBI NR]
  • glial cell derived neurotrophic factor [HGNC (HUGO)]
  • Glial cell line-derived neurotrophic factor OS=Homo sapiens GN=GDNF PE=1 SV=1 [Swiss-Prot]
  • Splice isoform 1 of P39905 [hmr_yeast5_DM3-1_pombe.fasta]
  • glial cell derived neurotrophic factor isoform 1 preproprotein; glial cell line derived neurotrophic factor; astrocyte-derived trophic factor [HMR_022704.fasta]
  • glial cell derived neurotrophic factor isoform 1 preproprotein; astrocyte-derived trophic factor; glial cell line derived neurotrophic factor [Human2242005.fasta]
  • PREDICTED: similar to glial cell derived neurotrophic factor isoform 1 preproprotein; astrocyte-derived trophic factor; glial cell line derived neurotrophic factor [Pan troglodytes]gi|4503975|ref|NP_000505.1| glial cell derived neurotrophic factor isofor [nrdb_11152004_Chlamydomonas]
  • Glial cell line-derived neurotrophic factor precursor (Astrocyte-derived trophic factor 1) (ATF-1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Glial cell line-derived neurotrophic factor precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000514) glial cell derived neurotrophic factor precursor; glial cell line derived neurotrophic factor [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • glial cell derived neurotrophic factor isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • glial cell derived neurotrophic factor isoform 1 preproprotein; astrocyte-derived trophic factor; glial cell line derived neurotrophic factor [Homo sapiens] [HumanGallus06162005.fasta]
  • glial cell derived neurotrophic factor isoform 1 preproprotein; glial cell line derived neurotrophic factor; astrocyte-derived trophic factor [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Glial cell line-derived neurotrophic factor precursor (Astrocyte-derived trophic factor) (ATF) (hGDNF) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Glial cell derived neurotrophic factor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • GDNF [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • neurotrophic factor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Glial cell line-derived neurotrophic factor precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Glial cell line-derived neurotrophic factor; AltName: Full=Astrocyte-derived trophic factor; Short=ATF; Short=hGDNF; Flags: Precursor [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=GDNF Isoform 1 of Glial cell line-derived neurotrophic factor [human-ipi-250309-contam.fasta]
  • IPI:IPI00026858.1|SWISS-PROT:P39905-1|ENSEMBL:ENSP00000317145|REFSEQ:NP_000505|H-INV:HIT000263291|VEGA:OTTHUMP00000116024 Tax_Id=9606 Gene_Symbol=GDNF Isoform 1 of Glial cell line-derived neurotrophic factor [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=GDNF Isoform 1 of Glial cell line-derived neurotrophic factor precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • glial cell line-derived neurotrophic factor isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P39905;B7WPK7;O95448;O95449;O95986;Q6FH33;Q96L44;Q9UD32;Q9UD33;Q9UMV2;Q9UP67;Q9UP97; RecName: Full=Glial cell line-derived neurotrophic factor; AltName: Full=Astrocyte-derived trophic factor; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Glial cell line-derived neurotrophic factor OS=Homo sapiens GN=GDNF [011711_HMR.fasta]
  • GeneSymbol=GDNF Synonyms=ATF1|ATF2|HFB1-GDNF|HSCR3 glial cell line-derived neurotrophic factor isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Glial cell line-derived neurotrophic factor GN=GDNF [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 211 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ  60
   61 FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL 120
  121 TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR 180
  181 PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] MSA 3.020986 View MSA. No confident structure predictions are available.
    2 View Details [64..211] PSI-BLAST 45.39794 Glial cell-derived neurotrophic factor, GDNF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • vascular endothelial growth factor receptor 1 binding
    		•  4.88004110368356 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  4.8369569327215 bayes_pls_golite062009
  • receptor binding
    		•  4.70889547404918 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  4.69128752159226 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  4.69128752159226 bayes_pls_golite062009
  • glial cell line-derived neurotrophic factor receptor binding
    		•  4.199474917569 bayes_pls_golite062009
  • growth factor activity
    		•  4.01406832911234 bayes_pls_golite062009
  • cytokine activity
    		•  3.61376517935324 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  3.16494996397951 bayes_pls_golite062009
  • protein binding
    		•  3.16282476674164 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  3.0813162230094 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  3.06631842262117 bayes_pls_golite062009
  • cell surface binding
    		•  2.9725198156666 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49731836866959 bayes_pls_golite062009
  • growth factor binding
    		•  2.41942870726502 bayes_pls_golite062009
  • binding
    		•  2.37954321554411 bayes_pls_golite062009
  • heparin binding
    		•  2.11784489374422 bayes_pls_golite062009
  • hormone activity
    		•  2.10500409590202 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  1.78479767888975 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.44846386076063 bayes_pls_golite062009
  • fibronectin binding
    		•  1.3732716084502 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  1.18476084022243 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.16191864095271 bayes_pls_golite062009
  • protein homodimerization activity
    		•  1.13743310822539 bayes_pls_golite062009
  • collagen binding
    		•  1.00551310632663 bayes_pls_golite062009
  • identical protein binding
    		•  1.0030262164995 bayes_pls_golite062009
  • morphogen activity
    		•  0.91146826241391 bayes_pls_golite062009
  • pattern binding
    		•  0.90497366619649 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 3 binding
    		•  0.772832351269279 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.408562885230686 bayes_pls_golite062009
  • transcription activator activity
    		•  0.290946570822357 bayes_pls_golite062009
  • catalytic activity
    		•  0.105223830172599 bayes_pls_golite062009
  • signal transducer activity
    		•  0.102347067903142 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.102347067903142 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0706173408709216 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0235054088545197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle