| Protein: | GDNF |
| Organism: | Homo sapiens |
| Length: | 211 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GDNF.
| Description | E-value | Query Range |
Subject Range |
|
|
1.0E-81 | [1..211] | [30..240] |
|
|
2.0E-81 | [1..211] | [1..218] |
|
|
1.0E-80 | [1..211] | [18..228] |
|
|
2.0E-80 | [1..211] | [1..211] |
|
|
3.0E-80 | [1..211] | [154..364] |
|
|
3.0E-79 | [1..211] | [55..265] |
|
|
3.0E-79 | [1..211] | [1..211] |
|
|
2.0E-78 | [1..211] | [1..211] |
|
Region A: Residues: [1-63] |
1 11 21 31 41 51
| | | | | |
1 MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ 60
61 FDD
|
| Detection Method: |  |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [64-211] |
1 11 21 31 41 51
| | | | | |
1 VMDFIQATIK RLKRSPDKQM AVLPRRERNR QAAAANPENS RGKGRRGQRG KNRGCVLTAI 60
61 HLNVTDLGLG YETKEELIFR YCSGSCDAAE TTYDKILKNL SRNRRLVSDK VGQACCRPIA 120
121 FDDDLSFLDD NLVYHILRKH SAKRCGCI
|
| Detection Method: | |
| Confidence: | 45.39794 |
| Match: | 1agqA |
| Description: | Glial cell-derived neurotrophic factor, GDNF |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| vascular endothelial growth factor receptor 1 binding | 4.88004110368356 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 4.8369569327215 | bayes_pls_golite062009 |
| receptor binding | 4.70889547404918 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 4.69128752159226 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 4.69128752159226 | bayes_pls_golite062009 |
| glial cell line-derived neurotrophic factor receptor binding | 4.199474917569 | bayes_pls_golite062009 |
| growth factor activity | 4.01406832911234 | bayes_pls_golite062009 |
| cytokine activity | 3.61376517935324 | bayes_pls_golite062009 |
| vascular endothelial growth factor receptor binding | 3.16494996397951 | bayes_pls_golite062009 |
| protein binding | 3.16282476674164 | bayes_pls_golite062009 |
| vascular endothelial growth factor receptor 2 binding | 3.0813162230094 | bayes_pls_golite062009 |
| type II transforming growth factor beta receptor binding | 3.06631842262117 | bayes_pls_golite062009 |
| cell surface binding | 2.9725198156666 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 2.49731836866959 | bayes_pls_golite062009 |
| growth factor binding | 2.41942870726502 | bayes_pls_golite062009 |
| binding | 2.37954321554411 | bayes_pls_golite062009 |
| heparin binding | 2.11784489374422 | bayes_pls_golite062009 |
| hormone activity | 2.10500409590202 | bayes_pls_golite062009 |
| platelet-derived growth factor receptor binding | 1.78479767888975 | bayes_pls_golite062009 |
| protein dimerization activity | 1.44846386076063 | bayes_pls_golite062009 |
| fibronectin binding | 1.3732716084502 | bayes_pls_golite062009 |
| platelet-derived growth factor binding | 1.18476084022243 | bayes_pls_golite062009 |
| polysaccharide binding | 1.16191864095271 | bayes_pls_golite062009 |
| protein homodimerization activity | 1.13743310822539 | bayes_pls_golite062009 |
| collagen binding | 1.00551310632663 | bayes_pls_golite062009 |
| identical protein binding | 1.0030262164995 | bayes_pls_golite062009 |
| morphogen activity | 0.91146826241391 | bayes_pls_golite062009 |
| pattern binding | 0.90497366619649 | bayes_pls_golite062009 |
| neurotrophin receptor binding | 0.81172494974121 | bayes_pls_golite062009 |
| vascular endothelial growth factor receptor 3 binding | 0.772832351269279 | bayes_pls_golite062009 |
| protein heterodimerization activity | 0.408562885230686 | bayes_pls_golite062009 |
| transcription activator activity | 0.290946570822357 | bayes_pls_golite062009 |
| catalytic activity | 0.105223830172599 | bayes_pls_golite062009 |
| signal transducer activity | 0.102347067903142 | bayes_pls_golite062009 |
| molecular transducer activity | 0.102347067903142 | bayes_pls_golite062009 |
| transcription regulator activity | 0.0706173408709216 | bayes_pls_golite062009 |
| carbohydrate binding | 0.0235054088545197 | bayes_pls_golite062009 |
