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Protein Overview: GAPDH

General Information:
Name(s) found: GAPDH [HGNC (HUGO)]
Description(s) found:
Found 60 descriptions.
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  • glyceraldehyde-3-phosphate dehydrogenase [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 335 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKVKVGVNG FGRIGRLVTR AAFNSGKVDI VAINDPFIDL NYMVYMFQYD STHGKFHGTV  60
   61 KAENGKLVIN GNPITIFQER DPSKIKWGDA GAEYVVESTG VFTTMEKAGA HLQGGAKRVI 120
  121 ISAPSADAPM FVMGVNHEKY DNSLKIISNA SCTTNCLAPL AKVIHDNFGI VEGLMTTVHA 180
  181 ITATQKTVDG PSGKLWRDGR GALQNIIPAS TGAAKAVGKV IPELNGKLTG MAFRVPTANV 240
  241 SVVDLTCRLE KPAKYDDIKK VVKQASEGPL KGILGYTEHQ VVSSDFNSDT HSSTFDAGAG 300
  301 IALNDHFVKL ISWYDNEFGY SNRVVDLMAH MASKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..335] PSI-BLAST 147.0 Crystal Structure Of Human Placental Glyceraldehyde-3-Phosphate Dehydrogenase At 1.75 Resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
    		•  3.16750187025282 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • glucose-6-phosphate dehydrogenase activity
    		•  2.2713146106379 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • DNA binding
    		•  1.61355789916908 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.55390653047158 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48478425318425 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
    		•  1.0729055844832 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase activity
    		•  1.04861088194764 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91090893050278 bayes_pls_golite062009
  • signal transducer activity
    		•  0.910536752370264 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.910536752370264 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.88293430762998 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.74536049628503 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.527946013169731 bayes_pls_golite062009
  • hydrolase activity
    		•  0.41684292392606 bayes_pls_golite062009
  • receptor activity
    		•  0.388215697182664 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • structural molecule activity
    		•  0.345975336806588 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.331048046502169 bayes_pls_golite062009
  • collagen binding
    		•  0.30621400535957 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.211380641599388 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.136079082491021 bayes_pls_golite062009
  • glucose binding
    		•  0.13030486887358 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle