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Protein Overview: PGA3, PGA5, PGA4

General Information:
Name(s) found: PGA5 [HGNC (HUGO)]
PGA4 [HGNC (HUGO)]
PGA3 [HGNC (HUGO)]
Description(s) found:
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  • gi|89034012|ref|XP_932724.1| PREDICTED: similar to Pepsin A precursor isoform 1 [Homo sapiens] [NCBI NR]
  • pir||PEHU pepsin A (EC 3.4.23.1) 3 precursor [validated] - human [NCBI NR]
  • gi|387012|gb|AAA98529.1| pepsinogen [NCBI NR]
  • gi|223462201|gb|AAI50660.1| Pepsinogen 4, group I (pepsinogen A) [Homo sapiens] [NCBI NR]
  • gi|219521176|gb|AAI71910.1| Pepsinogen 4, group I (pepsinogen A) [Homo sapiens] [NCBI NR]
  • gi|219520853|gb|AAI71920.1| Pepsinogen 4, group I (pepsinogen A) [Homo sapiens] [NCBI NR]
  • gi|129792|sp|P00790.1|PEPA_HUMAN RecName: Full=Pepsin A; Flags: Precursor [NCBI NR]
  • gi|119372302|ref|NP_001073276.1| pepsinogen 4, group I [Homo sapiens] [NCBI NR]
  • gi|113422417|ref|XP_001129528.1| PREDICTED: similar to Pepsin A precursor [Homo sapiens] [NCBI NR]
  • pepsinogen 5, group I (pepsinogen A) [HGNC (HUGO)]
  • pepsinogen 4, group I (pepsinogen A) [HGNC (HUGO)]
  • pepsinogen 3, group I (pepsinogen A) [HGNC (HUGO)]
  • Pepsin A OS=Homo sapiens GN=PGA3 PE=1 SV=1 [Swiss-Prot]
  • Pepsin A-4 OS=Homo sapiens GN=PGA4 PE=1 SV=1 [Swiss-Prot]
  • Pepsin A precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • pepsin A (EC 3.4.23.1) 3 precursor [validated] - humangi|387012|gb|AAA98529.1| pepsinogengi|129792|sp|P00790|PEPA_HUMAN Pepsin A precursor [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Pepsin A precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • PREDICTED: similar to Pepsin A precursor isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • PREDICTED: similar to Pepsin A precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • pepsinogen 4, group I [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • pepsinogen [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 PEPSIN A PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PGA5;PGA4;PGA3 Pepsin A [human-ipi-250309-contam.fasta]
  • pepsinogen 4, group I precursor [Homo sapiens] [NCBI-RefSeq_human_na_10-19-2009_con_reversed.fasta]
  • IPI:IPI00019641.1|SWISS-PROT:P00790|TREMBL:B7ZW10;B7ZW16;B7ZW66;B7ZW75|ENSEMBL:ENSP00000367391|REFSEQ:NP_001073276 Tax_Id=9606 Gene_Symbol=PGA4;PGA5;PGA3 Pepsin A [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PGA5;PGA3;PGA4 Pepsin A precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PGA4;PGA5;PGA3 Pepsin A [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • pepsin A preproprotein [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P00790;A8K749;B7ZW75;Q7M4R0;Q8N1E3; RecName: Full=Pepsin A; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Pepsin A OS=Homo sapiens GN=PGA3 [011711_HMR.fasta]
  • IPI:IPI00019641.1|SWISS-PROT:P00790|TREMBL:B7ZW10;B7ZW16;B7ZW66|ENSEMBL:ENSP00000367391|REFSEQ:NP_001073276 Tax_Id=9606 Gene_Symbol=PGA4;PGA5;PGA3 Pepsin A [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=PGA4 Synonyms=FLJ58952|FLJ77962|PGA3|PGA5 pepsin A preproprotein [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00019641.1|SWISS-PROT:P00790|TREMBL:B7ZW10;B7ZW16;B7ZW66|ENSEMBL:ENSP00000367391|REFSEQ:NP_001073276|VEGA:OTTHUMP00000237819 Tax_Id=9606 Gene_Symbol=PGA3;PGA5;PGA4 Pepsin A [ipi.HUMAN.20110912.fasta]
  • Pepsin A-4 GN=PGA4 [Doctor+uniprot-HUMAN-120911.fasta]
  • Tax_Id=9606 Gene_Symbol=PGA3;PGA4;PGA5 Pepsin A [human-ipi-270911-contam-BSA.fasta]
  • IPI:IPI00019641.1|SWISS-PROT:P00790|TREMBL:B7ZW10;B7ZW16;B7ZW66|ENSEMBL:ENSP00000367391|REFSEQ:NP_001073276|VEGA:OTTHUMP00000237819 Tax_Id=9606 Gene_Symbol=PGA3;PGA4;PGA5 Pepsin A [ipi.HUMAN.fasta.20110927]
    • Organism: Homo sapiens
    Length: 388 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP  60
   61 TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP 120
  121 EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD 180
  181 GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DQSGSVVIFG GIDSSYYTGS 240
  241 LNWVPVTVEG YWQITVDSIT MNGEAIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS 300
  301 ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNLPTESGEL 360
  361 WILGDVFIRQ YFTVFDRANN QVGLAPVA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..388] PSI-BLAST 107.0 REFINED STRUCTURE OF PORCINE PEPSINOGEN AT 1.8 ANGSTROMS RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aspartic-type endopeptidase activity
    		•  7.9145950161796 bayes_pls_golite062009
  • aspartic-type peptidase activity
    		•  7.9145950161796 bayes_pls_golite062009
  • peptidase activity
    		•  5.78181196721293 bayes_pls_golite062009
  • endopeptidase activity
    		•  5.4888481808613 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  5.39972232367526 bayes_pls_golite062009
  • hydrolase activity
    		•  4.34796304893506 bayes_pls_golite062009
  • catalytic activity
    		•  1.54514410489082 bayes_pls_golite062009
  • protein binding
    		•  1.24436201877985 bayes_pls_golite062009
  • binding
    		•  1.10054369202721 bayes_pls_golite062009
  • receptor binding
    		•  1.06854757360057 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle